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NKAP cDNA Clone – NFKB Activating Protein (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1275258

MBS1275258 is a cDNA clone targeting NKAP. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKAP, cDNA Clone
Full Product Name
NKAP cDNA Clone
Product Gene Name
NKAP cdna clone
Sequence
atggctccgg tgtccggctc acgcagcccg gatagggagg cctcgggctc ggggggaaga cgtcgcagtt cgtcgaagag tccgaagccc agcaaatctg cccgctcccc gcggggccgc cgctctcgct cgcactcttg ctctcggtcc ggggaccgga atggactcac ccatcagctg ggtggcctca gccaaggctc ccgaaaccag tcctaccgct cacgctcgcg gtcgcgttct agagagcggc cctctgcgcc ccggggcatc cccttcgctt ctgcctcctc gtcagtctat tacggcagct actcgcgccc ctacgggagc gacaagcctt ggcctagcct cctcgacaag gagagggagg agagcctgcg gcagaagaga ttaagtgaga gagagagaat tggagaattg ggagctcctg aagtatgggg actttctcca aagaatcctg aaccagattc tgatgaacat acaccagtgg aggatgaaga gccaaagaaa agcactactt cagcttctac ttcagaagaa gaaaaaaaga agaagtctag ccgttcaaaa gaaaggtcca agaaaaggag aaagaaaaaa tcatcgaaaa gaaaacataa gaagtattct gaagatagcg acagtgactc tgattctgaa acagactcca gtgatgaaga taacaaaagg agagcaaaga aagccaagaa aaaggaaaag aagaagaaac acagatcgaa gaaatataag aaaaagaggt ctaagaagag cagaaaagag tccagtgatt caagctctaa agaatcccaa gaagagtttc tggaaaatcc ctggaagtat cgaacaaagg ctgaagaacc atcagattta attggcccag aggctccaaa aacacttacc tctcaagatg ataaaccttt gaactatggc catgctctgt tacctggtga aggtgcagct atggctgaat atgtaaaagc tggaaaacgt atcccacgaa gaggtgaaat tggcttgaca agtgaagaaa ttgcatcatt tgaatgctca ggttatgtaa tgagtggtag caggcatcgc cgaatggagg ctgtgcgact gcgaaaagag aaccagatct acagtgctga tgagaagaga gcccttgcat cctttaacca agaagagaga cgaaagagag agaacaagat tctggccagt tttcgagaaa tggtttacag aaagaccaaa gggaaggatg acaaataa
Molecular Weight
47,138 Da
OMIM
300766
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NKAP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NKAP. It may not necessarily be applicable to this product.

NCBI GI #
15929863
NCBI GeneID
79576
NCBI Accession #
BC015354
UniProt Secondary Accession #
Q6IPW6; Q96BQ2; Q9H638
UniProt Related Accession #
Q8N5F7
NCBI Official Full Name
Homo sapiens NFKB activating protein, mRNA
NCBI Official Synonym Full Names
NFKB activating protein
NCBI Official Symbol
NKAP
UniProt Protein Name
NF-kappa-B-activating protein
Protein Family
NF-kappa-B-activating protein
UniProt Gene Name
NKAP
UniProt Entry Name
NKAP_HUMAN
NCBI Protein Information
NF-kappa-B-activating protein

NCBI Summary for NKAP

This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
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UniProt Comments for NKAP

NKAP: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the UPF0396 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: chromatin binding; protein binding

Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell differentiation
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Research Articles on NKAP

1. NKAP is required for T cell maturation and the acquisition of functional competency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with NKAP cdna clone

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with NKAP and Necrosis
 Inflammation Antibodies  >1 publications with NKAP and Inflammation
 Disease Models, Animal Antibodies  >1 publications with NKAP and Disease Models, Animal

Organs/Tissues associated with NKAP cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with NKAP and Blood
 Bone Marrow Antibodies  >1 publications with NKAP and Bone Marrow
 Bone Antibodies  >1 publications with NKAP and Bone
 Liver Antibodies  >1 publications with NKAP and Liver
 Thymus Antibodies  >1 publications with NKAP and Thymus
 Eye Antibodies  >1 publications with NKAP and Eye
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