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NOX4 cDNA Clone – NADPH Oxidase 4 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269330

MBS1269330 is a cDNA clone targeting NOX4. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NOX4, cDNA Clone
Full Product Name
NOX4 cDNA Clone
Product Gene Name
NOX4 cdna clone
Sequence
atggctgtgt cctggaggag ctggctcgcc aacgaagggg ttaaacacct ctgcctgttc atctggctct ccatgaatgt cctgcttttc tggaaaacct tcttgctgta taaccaaggg ccagagtatc actacctcca ccagatgttg gggctaggat tgtgtctaag cagagcctca gcatctgttc ttaacctcaa ctgcagcctt atccttttac ccatgtgccg aacactcttg gcttacctcc gaggatcaca gaaggttcca agcaggagaa ccaggagatt gttggataaa agcagaacat tccatattac ctgtggtgtt actatctgta ttttctcagg cgtgcatgtg gctgcccatc tggtgaatgc cctcaacttc tcagtgaatt acagtgaaga ctttgttgaa ctgaatgcag caagataccg agatgaggat cctagaaaac ttctcttcac aactgttcct ggcctgacag gggtctgcat ggtggtggtg ctattcctca tgatcacagc ctctacatat gcaataagag tttctaacta tgatatcttc tggtatactc ataacctctt ctttgtcttc tacatgctgc tgacgttgca tgtttcagga gggctgctga agtatcaaac taatttagat acccaccctc ccggctgcat cagtcttaac cgaaccagct ctcagaatat ttccttacca gagtatttct cagaacattt tcatgaacct ttccctgaag gattttcaaa accggcagag tttacccagc acaaatttgt gaagatttgt atggaagagc ccagattcca agctaatttt ccacagactt ggctttggat ttctggacct ttgtgcctgt actgtgccga aagactttac aggtatatcc ggagcaataa gccagtcacc atcatttcgg tcataagtca tccctcagat gtcatggaaa tccgaatggt caaagaaaat tttaaagcaa gacctggtca gtatattact ctacattgtc ccagtgtatc tgcattagaa aatcatccat ttaccctcac aatgtgtcca actgaaacca aagcaacatt tggggttcat cttaaaatag taggagactg gacagaacga tttcgagatt tactactgcc tccatctagt caagactccg aaattctgcc cttcattcaa tctagaaatt atcccaagct gtatattgat ggtccttttg gaagtccatt tgaggaatca ctgaactatg aggtcagcct ctgcgtggct ggaggcattg gagtaactcc atttgcatca atactcaaca ccctgttgga tgactggaaa ccatacaagc ttagaagact atactttatt tgggtatgca gagatatcca gtccttccgt tggtttgcag atttactctg tatgttgcat aacaagtttt ggcaagagaa cagacctgac tatgtcaaca tccagctgta cctcagtcaa acagatggga tacagaagat aattggagaa aaatatcatg cactgaattc aagactgttt ataggacgtc ctcggtggaa acttttgttt gatgaaatag caaaatataa cagaggaaaa acagttggtg ttttctgttg tggacccaat tcactatcca agactcttca taaactgagt aaccagaaca actcatatgg gacaagattt gaatacaata aagagtcttt cagctga
Molecular Weight
59,915 Da
OMIM
605261
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NOX4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NOX4. It may not necessarily be applicable to this product.

NCBI GI #
25304043
NCBI GeneID
50507
NCBI Accession #
BC040105
UniProt Secondary Accession #
Q5K3R4; Q5K3R5; Q5K3R6; Q5K3R8; Q7Z7G3; Q86V92; A8K715; B7Z520; E7EMD7
UniProt Related Accession #
Q9NPH5
NCBI Official Full Name
Homo sapiens NADPH oxidase 4, mRNA
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Official Symbol
NOX4
NCBI Official Synonym Symbols
KOX; KOX-1; RENOX
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase
Protein Family
NADPH oxidase
UniProt Gene Name
NOX4
UniProt Synonym Gene Names
RENOX; KOX-1
UniProt Entry Name
NOX4_HUMAN
NCBI Protein Information
NADPH oxidase 4

NCBI Summary for NOX4

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
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UniProt Comments for NOX4

NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Nucleolus; Membrane protein, multi-pass; Cell cycle regulation; Membrane protein, integral; EC 1.6.3.-

Chromosomal Location of Human Ortholog: 11q14.2-q21

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: electron carrier activity; FAD binding; heme binding; NAD(P)H oxidase activity; nucleotide binding; oxygen sensor activity; protein binding; superoxide-generating NADPH oxidase activity

Biological Process: cell aging; cell morphogenesis; gene expression; homocysteine metabolic process; inflammatory response; negative regulation of cell proliferation; response to reactive oxygen species; superoxide metabolic process; superoxide release
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Research Articles on NOX4

1. Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NOX4 cdna clone

 Products by Pathway  Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Signaling Events Mediated By PTP1B Pathway antibodies  Signaling Events Mediated By PTP1B Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with NOX4 cdna clone

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >189 publications with NOX4 and Cardiovascular Diseases
 Hypertension Antibodies  >133 publications with NOX4 and Hypertension
 Inflammation Antibodies  >113 publications with NOX4 and Inflammation
 Fibrosis Antibodies  >98 publications with NOX4 and Fibrosis
 Heart Diseases Antibodies  >78 publications with NOX4 and Heart Diseases
 Kidney Diseases Antibodies  >73 publications with NOX4 and Kidney Diseases
 Atherosclerosis Antibodies  >70 publications with NOX4 and Atherosclerosis
 Hypertrophy Antibodies  >68 publications with NOX4 and Hypertrophy
 Neoplasms Antibodies  >63 publications with NOX4 and Neoplasms
 Necrosis Antibodies  >41 publications with NOX4 and Necrosis

Organs/Tissues associated with NOX4 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >352 publications with NOX4 and Vascular
 Kidney Antibodies  >147 publications with NOX4 and Kidney
 Brain Antibodies  >33 publications with NOX4 and Brain
 Connective Tissue Antibodies  >26 publications with NOX4 and Connective Tissue
 Embryonic Tissue Antibodies  >19 publications with NOX4 and Embryonic Tissue
 Eye Antibodies  >16 publications with NOX4 and Eye
 Pancreas Antibodies  >7 publications with NOX4 and Pancreas
 Intestine Antibodies  >5 publications with NOX4 and Intestine
 Mouth Antibodies  >3 publications with NOX4 and Mouth
 Placenta Antibodies  >3 publications with NOX4 and Placenta
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