Human NPSR1 cDNA Clone Expression Plasmid – Cat# MBS1267023

NPSR1 cDNA Clone – Neuropeptide S Receptor 1 (Human)

Name: NPSR1 cDNA Clone; Neuropeptide S Receptor 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267023
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267023

MBS1267023 is a cDNA clone targeting NPSR1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NPSR1, cDNA Clone

Full Product Name

NPSR1 cDNA Clone

Product Gene Name

NPSR1 cdna clone

Sequence

atgccagcca acttcacaga gggcagcttc gattccagtg ggaccgggca gacgctggat tcttccccag tggcttgcac tgaaacagtg acttttactg aagtggtgga aggaaaggaa tggggttcct tctactactc ctttaagact gagcaattga taactctgtg ggtcctcttt gtttttacca ttgttggaaa ctccgttgtg cttttttcca catggaggag aaagaagaag tcaagaatga ccttctttgt gactcagctg gccatcacag attctttcac aggactggtc aacatcttga cagatattaa ttggcgattc actggagact tcacggcacc tgacctggtt tgccgagtgg tccgctattt gcaggttgtg ctgctctacg cctctaccta cgtcctggtg tccctcagca tagacagata ccatgccatc gtctacccca tgaagttcct tcaaggagaa aagcaagcca gggtcctcat tgtgatcgcc tggagcctgt cttttctgtt ctccattccc accctgatca tatttgggaa gaggacactg tccaacggtg aagtgcagtg ctgggccctg tggcctgacg actcctactg gaccccatac atgaccatcg tggccttcct ggtgtacttc atccctctga caatcatcag catcatgtat ggcattgtga tccgaactat ttggattaaa agcaaaacct acgaaacagt gatttccaac tgctcagatg ggaaactgtg cagcagctat aaccgaggac tcatctcaaa ggcaaaaatc aaggctatca agtatagcat catcatcatt cttgccttca tctgctgttg gagtccatac ttcctgtttg acattttgga caatttcaac ctccttccag acacccagga gcgtttctat gcctctgtga tcattcagaa cctgccagca ttgaatagtg ccatcaaccc cctcatctac tgtgtcttca gcagctccat ctctttcccc tgcagggtca tccgtctccg tcagctccag gaggctgcgc taatgctctg ccctcaacga gagaactgga agggtacttg gccaggtgta ccttcctggg ctcttccaag gtga

Molecular Weight

10,612 Da

OMIM

608584

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NPSR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NPSR1. It may not necessarily be applicable to this product.

NCBI GI #

124376849

NCBI GeneID

387129

NCBI Accession #

BC132693

UniProt Secondary Accession #

Q2XP58; Q56H76; Q56H77; Q56H78; Q6JSL4; Q6JSL5; Q6JSL6; Q6JSL7; Q6JSL8; Q6W5P3; A2RTZ4

UniProt Related Accession #

Q6W5P4

NCBI Official Full Name

Homo sapiens neuropeptide S receptor 1, mRNA

NCBI Official Synonym Full Names

neuropeptide S receptor 1

NCBI Official Symbol

NPSR1

NCBI Official Synonym Symbols

GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154

UniProt Protein Name

Neuropeptide S receptor

UniProt Synonym Protein Names

G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility

Protein Family

Neuropeptide S receptor

UniProt Gene Name

NPSR1

UniProt Synonym Gene Names

GPR154; GPRA; PGR14

UniProt Entry Name

NPSR1_HUMAN

NCBI Protein Information

neuropeptide S receptor

NCBI Summary for NPSR1

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UniProt Comments for NPSR1

NPSR1: May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide receptor activity

Biological Process: positive regulation of release of sequestered calcium ion into cytosol

Disease: Asthma-related Traits, Susceptibility To, 2

Research Articles on NPSR1

1. findings demonstrate that hNPS-(1-10) is a biased agonist favoring Galphaq-dependent signaling. It may represent a valuable chemical probe for further investigation of the therapeutic potential of human NPS receptor-directed signalingin vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NPSR1 cdna clone

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with NPSR1 cdna clone

Disease Name	Pubmed Publications
Asthma Antibodies	>46 publications with NPSR1 and Asthma
Mental Disorders Antibodies	>8 publications with NPSR1 and Mental Disorders
Nervous System Diseases Antibodies	>3 publications with NPSR1 and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with NPSR1 and Brain Diseases
Cardiovascular Diseases Antibodies	>2 publications with NPSR1 and Cardiovascular Diseases
Autoimmune Diseases Antibodies	>2 publications with NPSR1 and Autoimmune Diseases
Learning Disorders Antibodies	>2 publications with NPSR1 and Learning Disorders
Fetal Death Antibodies	>1 publications with NPSR1 and Fetal Death
Fetal Diseases Antibodies	>1 publications with NPSR1 and Fetal Diseases
Edema Antibodies	>1 publications with NPSR1 and Edema

Organs/Tissues associated with NPSR1 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>22 publications with NPSR1 and Brain
Eye Antibodies	>1 publications with NPSR1 and Eye