Human NR2C2 cDNA Clone Expression Plasmid – Cat# MBS1278110

NR2C2 cDNA Clone – Nuclear Receptor Subfamily 2, Group C, Member 2 (Human)

Name: NR2C2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1278110
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278110

MBS1278110 is a cDNA clone targeting NR2C2. More details

$625 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NR2C2, cDNA Clone

Full Product Name

NR2C2 cDNA Clone

Product Gene Name

NR2C2 cdna clone

Sequence

atgaccagcc cctccccacg catccagata atctccaccg actctgctgt agcctcacct cagcgcattc agggctctga acctgcctct ggcccattga gtgttttcac atctttgaac aaagagaaga ttgtcacaga ccagcagaca ggacagaaaa tccagatagt caccgcagtg gacgcctccg gatcccccaa acagcagttc accctgacca gcccagatgg agctggaact gggaaggtga tcctggcttc cccagagaca tccagcgcca agcaactcat attcaccacc tcagacaacc tcgtccctgg caggatccag attgtcacgg attctgcctc tgtggagcgt ttactgggga agacggacgt ccagcggccc caggtggtag agtactgtgt ggtctgtggc gacaaagcct ccggccgtca ctatggggct gtcagttgtg aaggttgcaa aggtttcttc aaaaggagtg tgaggaaaaa tttgacctac agctgccgga gcaaccaaga ctgcatcatc aataaacatc accggaaccg ctgtcagttt tgccggctga aaaaatgctt agagatgggc atgaaaatgg aatctgtgca gagtaaacgg aagcccttcg atgtgcaacg ggagaaacca agcaattgtg ctgcttcaac tgagaaaatc tatatccgga aagacctgag aagtcccctg atagctactc ccacgtttgt ggcagacaaa gatggagcaa gacaaacagg tcttcttgat ccagggatgc ttgtgaacat ccagcagcct ttgatacgtg aggatggtac agttctcctg gccacggatt ctaaggctga aacaagccag ggagctctgg gcacactggc aaatgtagtg acctcccttg ccaacctaag tgaatctttg aacaacggtg acacttcaga aatccagcca gaggaccagt ctgcaagtga gataactcgg gcatttgata ccttagctaa agcacttaat accacagaca gctcctcttc tccaagcttg gcagatggga tagacaccag tggaggaggg agcatccacg tcatcagcag agaccagtcg acacccatca ttgaggttga aggccccctc ctttcagaca cacacgtcac atttaagcta acaatgccca gtccaatgcc agagtacctc aacgtgcact acatctgtga gtctgcatcc cgtctgcttt tcctctcaat gcactgggct cggtcaatcc cagcctttca ggcacttggg caggactgca acaccagcct tgtgcgggcc tgctggaatg agctcttcac cctcggcctg gcccagtgtg cccaggtcat gagtctctcc accatcctgg ctgccattgt caaccacctg cagaacagca tccaggaaga taaactttct ggtgaccgga taaagcaagt catggagcac atctggaagc tgcaggagtt ctgtaacagc atggcgaagc tggatataga tggctatgag tatgcatacc ttaaagctat agttctcttt agccccggta agatatgcgg tggggatgca tga

Molecular Weight

67,345 Da

OMIM

601426

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NR2C2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2C2. It may not necessarily be applicable to this product.

NCBI GI #

45708742

NCBI GeneID

7182

NCBI Accession #

BC051670

UniProt Secondary Accession #

P55092; A8K3H5; B6ZGT8

UniProt Related Accession #

P49116

NCBI Official Full Name

Homo sapiens nuclear receptor subfamily 2, group C, member 2, mRNA

NCBI Official Synonym Full Names

nuclear receptor subfamily 2 group C member 2

NCBI Official Symbol

NR2C2

NCBI Official Synonym Symbols

TR4; TAK1

UniProt Protein Name

Nuclear receptor subfamily 2 group C member 2

UniProt Synonym Protein Names

Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

NR2C2

UniProt Synonym Gene Names

TAK1; TR4

UniProt Entry Name

NR2C2_HUMAN

NCBI Protein Information

nuclear receptor subfamily 2 group C member 2

NCBI Summary for NR2C2

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

UniProt Comments for NR2C2

NR2C2: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm

Molecular Function: protein binding; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity

Biological Process: nervous system development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter

Research Articles on NR2C2

1. USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NR2C2 cdna clone

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram
Regulation Of Androgen Receptor Activity Pathway antibodies	Regulation Of Androgen Receptor Activity Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with NR2C2 cdna clone

Disease Name	Pubmed Publications
Thyroid Diseases Antibodies	>3 publications with NR2C2 and Thyroid Diseases
Anemia, Hemolytic Antibodies	>2 publications with NR2C2 and Anemia, Hemolytic
Nervous System Diseases Antibodies	>2 publications with NR2C2 and Nervous System Diseases
Inflammation Antibodies	>2 publications with NR2C2 and Inflammation
Glucose Intolerance Antibodies	>1 publications with NR2C2 and Glucose Intolerance
Ovarian Neoplasms Antibodies	>1 publications with NR2C2 and Ovarian Neoplasms
Fetal Growth Retardation Antibodies	>1 publications with NR2C2 and Fetal Growth Retardation
Fatty Liver Antibodies	>1 publications with NR2C2 and Fatty Liver
Liver Diseases Antibodies	>1 publications with NR2C2 and Liver Diseases
Necrosis Antibodies	>1 publications with NR2C2 and Necrosis

Organs/Tissues associated with NR2C2 cdna clone

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>59 publications with NR2C2 and Thyroid
Nerve Antibodies	>22 publications with NR2C2 and Nerve
Testis Antibodies	>14 publications with NR2C2 and Testis
Brain Antibodies	>10 publications with NR2C2 and Brain
Embryonic Tissue Antibodies	>5 publications with NR2C2 and Embryonic Tissue
Prostate Antibodies	>5 publications with NR2C2 and Prostate
Liver Antibodies	>5 publications with NR2C2 and Liver
Ovary Antibodies	>4 publications with NR2C2 and Ovary
Bone Antibodies	>4 publications with NR2C2 and Bone
Blood Antibodies	>3 publications with NR2C2 and Blood