Human OAT cDNA Clone Expression Plasmid – Cat# MBS1269144

OAT cDNA Clone – Ornithine Aminotransferase (Gyrate Atrophy) (Human)

Name: OAT cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269144
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269144

MBS1269144 is a cDNA clone targeting OAT. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OAT, cDNA Clone

Full Product Name

OAT cDNA Clone

Product Gene Name

OAT cdna clone

Sequence

atgttttcca aactagcaca tttgcagagg tttgctgtac ttagtcgcgg agttcattct tcagtggctt ctgctacatc tgttgcaact aaaaaaacag tccaaggccc tccaacctct gatgacattt ttgaaaggga atataagtat ggtgcacaca actaccatcc tttacctgta gccctggaga gaggaaaagg tatttactta tgggatgtag aaggcagaaa atattttgac ttcctgagtt cttacagtgc tgtcaaccaa gggcattgtc accccaagat tgtgaatgct ctgaagagtc aagtggacaa attgacctta acatctagag ctttctataa taacgtactt ggtgaatatg aggagtatat tactaaactt ttcaactacc acaaagttct tcctatgaat acaggagtgg aggctggaga gactgcctgt aaactagctc gtaagtgggg ctataccgtg aagggcattc agaaatacaa agcaaagatt gtttttgcag ctgggaactt ctggggtagg acgttgtctg ctatctccag ttccacagac ccaaccagtt acgatggttt tggaccattt atgccgggat tcgacatcat tccctataat gatctgcccg cactggagcg tgctcttcag gatccaaatg tggctgcgtt catggtagaa ccaattcagg gtgaagcagg cgttgttgtt ccggatccag gttacctaat gggagtgcga gagctctgca ccaggcacca ggttctcttt attgctgatg aaatacagac aggattggcc agaactggta gatggctggc tgttgattat gaaaatgtca gacctgatat agtcctcctt ggaaaggccc tttctggggg cttataccct gtgtctgcag tgctgtgtga tgatgacatc atgctgacca ttaagccagg ggagcatggg tccacatacg gtggcaatcc actaggctgc cgagtggcca tcgcagccct tgaggtttta gaagaagaaa accttgctga aaatgcagac aaattgggca ttatcttgag aaatgaactc atgaagctac cttctgatgt tgtaactgcc gtaagaggaa aaggattatt aaacgctatt gtcattaaag aaaccaaaga ttgggatgct tggaaggtgt gtctacgact tcgagataat ggacttctgg ccaagccaac ccatggcgac attatcaggt ttgcgcctcc gctggtgatc aaggaggatg agcttcgaga gtccattgaa attattaaca agaccatctt gtctttctga

Molecular Weight

32,853 Da

OMIM

258870

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of OAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OAT. It may not necessarily be applicable to this product.

NCBI GI #

16877349

NCBI GeneID

4942

NCBI Accession #

BC016928

UniProt Secondary Accession #

Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0

UniProt Related Accession #

P04181

NCBI Official Full Name

Homo sapiens ornithine aminotransferase (gyrate atrophy), mRNA

NCBI Official Synonym Full Names

ornithine aminotransferase

NCBI Official Symbol

OAT

NCBI Official Synonym Symbols

OKT; GACR; HOGA; OATASE

UniProt Protein Name

Ornithine aminotransferase, mitochondrial

UniProt Synonym Protein Names

Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase

Protein Family

Ornithine aminotransferase

UniProt Gene Name

OAT

UniProt Entry Name

OAT_HUMAN

NCBI Protein Information

ornithine aminotransferase, mitochondrial

NCBI Summary for OAT

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

UniProt Comments for OAT

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; Mitochondrial

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: identical protein binding; ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: amino acid biosynthetic process; arginine catabolic process to glutamate; arginine catabolic process to proline via ornithine; visual perception

Disease: Gyrate Atrophy Of Choroid And Retina

Research Articles on OAT

1. Sequencing of the gene for ornithine aminotransferase reveals a homozygous mutation in our patient (base exchange c.498C>A in Exon 4).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with OAT cdna clone

Products by Pathway	Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Urea Cycle And Metabolism Of Amino Groups Pathway antibodies	Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
Arginine Biosynthesis IV Pathway antibodies	Arginine Biosynthesis IV Pathway Diagram
Arginine Biosynthesis IV Pathway antibodies	Arginine Biosynthesis IV Pathway Diagram
Arginine Degradation I (arginase Pathway) antibodies	Arginine Degradation I (arginase Pathway) Diagram
Arginine Degradation I (arginase Pathway) antibodies	Arginine Degradation I (arginase Pathway) Diagram

Diseases associated with OAT cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1249 publications with OAT and Neoplasms
Carcinoma Antibodies	>1133 publications with OAT and Carcinoma
Lung Neoplasms Antibodies	>877 publications with OAT and Lung Neoplasms
Adenocarcinoma Antibodies	>349 publications with OAT and Adenocarcinoma
Carcinoma, Squamous Cell Antibodies	>285 publications with OAT and Carcinoma, Squamous Cell
Cardiovascular Diseases Antibodies	>250 publications with OAT and Cardiovascular Diseases
Neoplasm Metastasis Antibodies	>206 publications with OAT and Neoplasm Metastasis
Drug Toxicity Antibodies	>157 publications with OAT and Drug Toxicity
Heart Diseases Antibodies	>110 publications with OAT and Heart Diseases
Hyperlipidemias Antibodies	>96 publications with OAT and Hyperlipidemias

Organs/Tissues associated with OAT cdna clone

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>852 publications with OAT and Lung
Blood Antibodies	>813 publications with OAT and Blood
Liver Antibodies	>340 publications with OAT and Liver
Intestine Antibodies	>272 publications with OAT and Intestine
Kidney Antibodies	>267 publications with OAT and Kidney
Brain Antibodies	>223 publications with OAT and Brain
Heart Antibodies	>127 publications with OAT and Heart
Bone Antibodies	>121 publications with OAT and Bone
Vascular Antibodies	>112 publications with OAT and Vascular
Skin Antibodies	>97 publications with OAT and Skin