Human PAAF1 cDNA Clone Expression Plasmid – Cat# MBS1267725

PAAF1 cDNA Clone – Proteasomal Atpase-Associated Factor 1 (Human)

Name: PAAF1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267725
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267725

MBS1267725 is a cDNA clone targeting PAAF1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAAF1, cDNA Clone

Full Product Name

PAAF1 cDNA Clone

Product Gene Name

PAAF1 cdna clone

Sequence

atggcggcgc ctttgaggat tcagagcgac tgggcgcaag ccctcaggaa ggatgaaggg gaggcctggc tgagctgtca tcccccaggg aaaccatctt tgtatggcag cctgacttgt caaggaattg gcctagatgg catcccagag gttacagctt cagaaggatt tactgtgaat gaaataaaca agaaaagcat tcatatttca tgtccaaagg aaaatgcatc ttctaagttt ttggcaccat atactacttt ttccagaatt catacaaaga gtataacatg cctggacatt tccagcagag gaggtcttgg tgtgtcttct agtactgacg ggaccatgaa aatctggcag gcttccaatg gagaactcag gagagtattg gaaggacatg tgtttgatgt gaattgttgc aggtttttcc catcaggcct tgtggtcctg agtgggggaa tggatgccca gctgaagata tggtcagctg aagatgctag ctgcgtggtg accttcaaag gtcacaaagg aggtatcctg gatacagcca tcgttgatcg ggggaggaat gtggtgtctg cttctcgaga tgggacagca cgactttggg attgtgggcg ctcaggctgc ttgggagtcc ttgcagattg tggttcttct atcaatggag tggcggtggg tgctgctgac aactccataa accttggctc ccctgagcag atgcccagtg aacgggaggt tggaacagag gccaaaatgc tgctcttggc ccgggaagat aagaaacttc agtgcttggg actacagagc aggcagctgg tgttcctctt tattggctca gacgctttca actgctgtac ttttctctct ggcttcttgc tattggctgg gactcaagat ggaaacattt atcagctgga tgtgaggagt ccaagggctc cggtacaagt catccacaga tcaggagcac cagttctatc cctgctaagt gtcagagatg gattcattgc tagccaaggt gatggaagct gttttattgt ccagcaagac ttagactatg tcactgagct cactggggct gactgtgacc ctgtgtacaa ggtagccaca tgggagaagc agatctacac atgctgtcga gacggtcttg tacgacgcta ccagctttct gacctctga

Molecular Weight

29,982 Da

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PAAF1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAAF1. It may not necessarily be applicable to this product.

NCBI GI #

18204857

NCBI GeneID

80227

NCBI Accession #

BC021541

UniProt Secondary Accession #

Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9HAB6; A6NDR5; B4DPB0; B7ZAS9

UniProt Related Accession #

Q9BRP4

NCBI Official Full Name

Homo sapiens proteasomal ATPase-associated factor 1, mRNA

NCBI Official Synonym Full Names

proteasomal ATPase associated factor 1

NCBI Official Symbol

PAAF1

NCBI Official Synonym Symbols

PAAF; Rpn14; WDR71

UniProt Protein Name

Proteasomal ATPase-associated factor 1

UniProt Synonym Protein Names

Protein G-16; WD repeat-containing protein 71

Protein Family

Probable proteasomal ATPase-associated factor

UniProt Gene Name

PAAF1

UniProt Synonym Gene Names

WDR71

UniProt Entry Name

PAAF1_HUMAN

NCBI Protein Information

proteasomal ATPase-associated factor 1

NCBI Summary for PAAF1

This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

UniProt Comments for PAAF1

PAAF1: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Belongs to the WD repeat PAAF1/RPN14 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: proteasome complex

Molecular Function: protein binding

Research Articles on PAAF1

1. These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PAAF1 cdna clone

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with PAAF1 and Inflammation

Organs/Tissues associated with PAAF1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with PAAF1 and Blood