Human PAK2 cDNA Clone Expression Plasmid – Cat# MBS1273048

PAK2 cDNA Clone – P21 Protein (Cdc42/Rac)-Activated Kinase 2 (Human)

Name: PAK2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273048
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273048

MBS1273048 is a cDNA clone targeting PAK2. More details

$610 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAK2, cDNA Clone

Full Product Name

PAK2 cDNA Clone

Product Gene Name

PAK2 cdna clone

Sequence

atgtctgata acggagaact ggaagataag cctccagcac ctcctgtgcg aatgagcagc accatcttta gcactggagg caaagaccct ttgtcagcca atcacagttt gaaacctttg ccctctgttc cagaagagaa aaagcccagg cataaaatca tctccatatt ctcaggcaca gagaaaggaa gtaaaaagaa ggaaaaggaa cggccagaaa tttctcctcc atctgatttt gagcacacca tccatgttgg ttttgatgct gttactggag aattcactgg catgccagaa cagtgggctc gattactaca gacctccaat atcaccaaac tagagcaaaa gaagaaccct caggctgtgc tggatgtcct aaagttctac gactccaaca cagtgaagca gaaatatctg agctttactc ctcctgagaa agatggcttt ccttctggaa caccagcact gaatgccaag ggaacagaag cacccgcagt agtgacagag gaggaggatg atgatgaaga gactgctcct cccgttattg ccccgcgacc ggatcatacg aaatcaattt acacacggtc tgtaattgac cctgttcctg caccagttgg tgattcacat gttgatggtg ctgccaagtc tttagacaaa cagaaaaaga agactaagat gacagatgaa gagattatgg agaaattaag aactatcgtg agcataggtg accctaagaa aaaatataca agatatgaaa aaattggaca aagggcttct ggtacagttt tcactgctac tgacgttgca ctgggacagg aggttgctat caaacaaatt aatttacaga aacagccaaa gaaggaactg atcattaacg agattctggt gatgaaagaa ttgaaaaatc ccaacatcgt taactttttg gacagttacc tggtaggaga tgaattgttt gtggtcatgg aataccttgc tggggggtca ctcactgatg tggtaacaga aacgtgcatg gatgaagcac agattgctgc tgtatgcaga gagtgtttac aggcattgga gtttttacat gctaatcaag tgatccacag agacatcaaa agtgacaatg tacttttggg aatggaagga tctgttaagc tcactgactt tggtttctgt gcccagatca cccctgagca gagcaaacgc agtaccatgg tcggaacgcc atactggatg gcaccagagg tggttacacg gaaagcttat ggccctaaag tcgacatatg gtctctgggt atcatggcta ttgagatggt agaaggagag cctccatacc tcaatgaaaa tcccttgagg gccttgtacc taatagcaac taatggaacc ccagaacttc agaatccaga gaaactttcc ccaatatttc gggatttctt aaatcgatgt ttggaaatgg atgtggaaaa aaggggttca gccaaagaat tattacagca tcctttcctg aaactggcca aaccgttatc tagcttgaca ccactgatca tggcagctaa agaagcaatg aagagtaacc gttaa

Molecular Weight

58,043 Da

OMIM

605022

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PAK2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAK2. It may not necessarily be applicable to this product.

NCBI GI #

47482155

NCBI GeneID

5062

NCBI Accession #

BC069613

UniProt Secondary Accession #

Q13154; Q6ISC3

UniProt Related Accession #

Q13177

NCBI Official Full Name

Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 2, mRNA

NCBI Official Synonym Full Names

p21 (RAC1) activated kinase 2

NCBI Official Symbol

PAK2

NCBI Official Synonym Symbols

PAK65; PAKgamma

UniProt Protein Name

Serine/threonine-protein kinase PAK 2

UniProt Synonym Protein Names

Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

PAK2

UniProt Synonym Gene Names

PAK-2; p27; p34

UniProt Entry Name

PAK2_HUMAN

NCBI Protein Information

serine/threonine-protein kinase PAK 2

NCBI Summary for PAK2

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

UniProt Comments for PAK2

PAK2: a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function: identical protein binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; receptor signaling protein serine/threonine kinase activity

Biological Process: mitotic cell cycle; negative regulation of apoptosis; negative regulation of protein kinase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of defense response to virus by virus; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway

Research Articles on PAK2

1. PAK2 is a direct effector of TSC1-TSC2-RHEB signaling and a new target for rational drug therapy in TSC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PAK2 cdna clone

Products by Pathway	Pathway Diagram
Activation Of Rac Pathway antibodies	Activation Of Rac Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
C-MYC Pathway antibodies	C-MYC Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent Vav1 Pathway antibodies	CD28 Dependent Vav1 Pathway Diagram

Diseases associated with PAK2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>40 publications with PAK2 and Neoplasms
Nervous System Diseases Antibodies	>10 publications with PAK2 and Nervous System Diseases
Necrosis Antibodies	>9 publications with PAK2 and Necrosis
Breast Neoplasms Antibodies	>6 publications with PAK2 and Breast Neoplasms
Kidney Diseases Antibodies	>6 publications with PAK2 and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>5 publications with PAK2 and Cell Transformation, Neoplastic
Carcinoma, Hepatocellular Antibodies	>4 publications with PAK2 and Carcinoma, Hepatocellular
Carcinoma, Squamous Cell Antibodies	>4 publications with PAK2 and Carcinoma, Squamous Cell
Drug Toxicity Antibodies	>3 publications with PAK2 and Drug Toxicity
Disease Models, Animal Antibodies	>3 publications with PAK2 and Disease Models, Animal

Organs/Tissues associated with PAK2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>41 publications with PAK2 and Blood
Brain Antibodies	>15 publications with PAK2 and Brain
Kidney Antibodies	>14 publications with PAK2 and Kidney
Muscle Antibodies	>10 publications with PAK2 and Muscle
Vascular Antibodies	>10 publications with PAK2 and Vascular
Lung Antibodies	>6 publications with PAK2 and Lung
Heart Antibodies	>6 publications with PAK2 and Heart
Liver Antibodies	>6 publications with PAK2 and Liver
Bone Antibodies	>5 publications with PAK2 and Bone
Skin Antibodies	>5 publications with PAK2 and Skin