Human PAPSS1 cDNA Clone Expression Plasmid – Cat# MBS1268599

PAPSS1 cDNA Clone – 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (Human)

Name: PAPSS1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268599
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268599

MBS1268599 is a cDNA clone targeting PAPSS1. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAPSS1, cDNA Clone

Full Product Name

PAPSS1 cDNA Clone

Product Gene Name

PAPSS1 cdna clone

Sequence

atggagatcc ccgggagcct gtgcaagaaa gtcaagctga gcaataacgc gcagaactgg ggaatgcaga gagcaaccaa tgtcacctac caagcccatc atgtcagcag gaacaagaga ggtcaggtgg tggggaccag aggtggcttt cgtggttgca cagtttggct aacaggcttg tctggagcgg gaaagactac tgtgagcatg gccttggagg agtacctggt ttgtcatggt attccatgct acactctgga tggtgacaat attcgtcaag gtctcaataa aaatcttggc tttagtcctg aagacagaga agagaatgtt cgacgcatcg cagaagttgc taaactgttt gcagatgctg gcttagtgtg catcacaagt ttcatatcac cttacactca ggatcgcaac aatgcaaggc aaattcatga aggtgcaagt ttaccgtttt ttgaagtatt tgttgatgct cctctgcatg tttgtgaaca gagggatgtc aaaggactct acaaaaaagc ccgggcagga gaaattaaag gtttcactgg gatcgattct gaatatgaaa agccagaggc ccctgagttg gtgctgaaaa cagactcctg tgatgtaaat gactgtgtcc agcaagttgt ggaacttcta caggaacggg atattgtacc tgtggatgca tcttatgaag taaaagaact atatgtgcca gaaaataaac ttcatttggc aaaaacagat gcggaaacat taccagcact gaaaattaat aaagtggata tgcagtgggt gcaggttttg gcagaaggtt gggcaacccc attgaatggc tttatgagag agagggagta cttgcagtgc cttcattttg attgtcttct ggatggaggt gtcattaact tgtcagtacc tatagttctg actgcgactc atgaagataa agagaggctg gacggctgta cagcatttgc tctgatgtat gagggccgcc gtgtggccat tcttcgcaat ccagagtttt ttgagcacag gaaagaggag cgctgtgcca gacagtgggg aacgacatgc aagaaccacc cctatattaa gatggtgatg gaacaaggag attggctgat tggaggagat cttcaagtct tggatcgagt ttattggaat gatggtcttg atcagtatcg tcttactcct actgagctaa agcagaaatt taaagatatg aatgctgatg ctgtctttgc atttcaacta cgcaacccag tgcacaatgg acatgccctg ttaatgcagg atacccataa gcaacttcta gagaggggct accggcgccc tgtcctcctc ctccaccctc tgggtggctg gacaaaggat gacgatgttc ctttgatgtg gcgtatgaag cagcatgctg cagtgttgga ggaaggagtt ctgaatcctg agacgacagt ggtggccatc ttcccatctc ccatgatgta tgctggacca actgaggtcc agtggcattg cagagcacgg atggttgcag gagccaactt ttacattgtt ggacgagacc ctgctggcat gcctcatcca gaaacaggga aggatcttta tgagccaagt catggtgcca aagtgctgac gatggcccct ggtttaatca ctttggaaat agttcccttt cgagttgcag cttacaacaa gaaaaagaag cgtatggact actatgactc tgaacaccat gaagactttg aatttatttc aggaacacga atgcgcaaac ttgctcgaga aggccagaaa ccacctgaag gtttcatggc tcccaaggct tggaccgtgc tgacagaata ctacaaatcc ttggagaaag cttag

Molecular Weight

70,833 Da

OMIM

603262

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PAPSS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPSS1. It may not necessarily be applicable to this product.

NCBI GI #

30047098

NCBI GeneID

9061

NCBI Accession #

BC050627

UniProt Secondary Accession #

O43841; O75332; Q96FB1; Q96TF4; Q9P1P9; Q9UE98

UniProt Related Accession #

O43252

NCBI Official Full Name

Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1, mRNA

NCBI Official Synonym Full Names

3'-phosphoadenosine 5'-phosphosulfate synthase 1

NCBI Official Symbol

PAPSS1

NCBI Official Synonym Symbols

SK1; PAPSS; ATPSK1

UniProt Protein Name

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

UniProt Synonym Protein Names

Sulfurylase kinase 1; SK 1; SK1

Protein Family

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase

UniProt Gene Name

PAPSS1

UniProt Synonym Gene Names

ATPSK1; PAPSS; PAPS synthase 1; PAPSS 1; SK 1; SK1; SAT

UniProt Entry Name

PAPS1_HUMAN

NCBI Protein Information

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

NCBI Summary for PAPSS1

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

UniProt Comments for PAPSS1

PAPSS1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Protein type: Energy Metabolism - sulfur; Other Amino Acids Metabolism - selenoamino acid; Nucleotide Metabolism - purine; Kinase, other; EC 2.7.1.25; EC 2.7.7.4

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytosol

Molecular Function: adenylylsulfate kinase activity; nucleotidyltransferase activity; sulfate adenylyltransferase (ATP) activity

Biological Process: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; skeletal development; sulfate assimilation

Research Articles on PAPSS1

1. These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PAPSS1 cdna clone

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Cytosolic Sulfonation Of Small Molecules Pathway antibodies	Cytosolic Sulfonation Of Small Molecules Pathway Diagram
Formation Of PAPS Pathway antibodies	Formation Of PAPS Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Phase II Conjugation Pathway antibodies	Phase II Conjugation Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Selenocompound Metabolism Pathway antibodies	Selenocompound Metabolism Pathway Diagram
Selenocompound Metabolism Pathway antibodies	Selenocompound Metabolism Pathway Diagram
Sulfation Biotransformation Reaction Pathway antibodies	Sulfation Biotransformation Reaction Pathway Diagram

Diseases associated with PAPSS1 cdna clone

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>1 publications with PAPSS1 and Neoplasm Metastasis
Liver Diseases Antibodies	>1 publications with PAPSS1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with PAPSS1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with PAPSS1 and Liver Neoplasms
Kidney Diseases Antibodies	>1 publications with PAPSS1 and Kidney Diseases

Organs/Tissues associated with PAPSS1 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with PAPSS1 and Liver
Brain Antibodies	>3 publications with PAPSS1 and Brain
Bone Antibodies	>2 publications with PAPSS1 and Bone
Kidney Antibodies	>2 publications with PAPSS1 and Kidney
Intestine Antibodies	>1 publications with PAPSS1 and Intestine
Adrenal Gland Antibodies	>1 publications with PAPSS1 and Adrenal Gland
Placenta Antibodies	>1 publications with PAPSS1 and Placenta
Heart Antibodies	>1 publications with PAPSS1 and Heart
Skin Antibodies	>1 publications with PAPSS1 and Skin
Embryonic Tissue Antibodies	>1 publications with PAPSS1 and Embryonic Tissue