Human PDE3A cDNA Clone Expression Plasmid – Cat# MBS1273376

PDE3A cDNA Clone – Phosphodiesterase 3a, Cgmp-Inhibited (Human)

Name: PDE3A cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273376
Price: 1430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273376

MBS1273376 is a cDNA clone targeting PDE3A. More details

$1430 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDE3A, cDNA Clone

Full Product Name

PDE3A cDNA Clone

Product Gene Name

PDE3A cdna clone

Sequence

atggcagtgc ccggcgacgc tgcacgagtc agggacaagc ccgtccacag tggggtgagt caagccccca cggcgggccg ggactgccac catcgtgcgg accccgcatc gccgcgggac tcgggctgcc gtggctgctg gggagacctg gtgctgcagc cgctccggag ctctcggaaa ctttcctccg cgctgtgcgc gggctccctg tcctttctgc tggcgctgct ggtgaggctg gtccgcgggg aggtcggctg tgacctggag cagtgtaagg aggcggcggc ggcggaggag gaggaagcag ccccgggagc agaagggggc gtcttcccgg ggcctcgggg aggtgctccc gggggcggtg cgcggctcag cccctggctg cagccctcgg cgctgctctt cagtctcctg tgtgccttct tctggatggg cttgtacctc ctgcgcgccg gggtgcgcct gcctctggct gtcgcgctgc tggccgcctg ctgcgggggg gaagcgctcg tccagattgg gctgggcgtc ggggaggatc acttactctc actccccgcc gcgggggtgg tgctcagctg cttggccgcc gcgacatggc tggtgctgag gctgaggctg ggcgtcctca tgatcgcctt gactagcgcg gtcaggaccg tgtccctcat ttccttagag aggttcaagg tcgcctggag accttacctg gcgtacctgg ccggcgtgct ggggatcctc ttggccaggt acgtggaaca aatcttgccg cagtccgcgg aggcggctcc aagggagcat ttggggtccc agctgattgc tgggaccaag gaagatatcc cggtgtttaa gaggaggagg cggtccagct ccgtcgtgtc cgccgagatg tccggctgca gcagcaagtc ccatcggagg acctccctgc cctgtatacc gagggaacag ctcatggggc attcagaatg ggaccacaaa cgagggccaa gaggatcaca gtcttcagga accagtatta ctgtggacat cgccgtcatg ggcgaggccc acggcctcat taccgacctc ctggcagacc cttctcttcc accaaacgtg tgcacatcct tgagagccgt gagcaacttg ctcagcacac agctcacctt ccaggccatt cacaagccca gagtgaatcc cgttacttcg ctcagtgaaa actatacctg ttctgactct gaagagagct ctgaaaaaga caagcttgct attccaaagc gcctgagaag gagtttgcct cctggcttgt tgagacgagt ttcttccact tggaccacca ccacctcggc cacaggtcta cccaccttgg agcctgcacc agtacggaga gaccgcagca ccagcatcaa actgcaggaa gcaccttcat ccagtcctga ttcttggaat aatccagtga tgatgaccct caccaaaagc agatccttta cttcatccta tgctatttct gcagctaacc atgtaaaggc taaaaagcaa agtcgaccag gtgccctcgc taaaatttca cctctttcat cgccctgctc ctcacctctc caagggactc ctgccagcag cctggtcagc aaaatttctg cagtgcagtt tccagaatct gctgacacaa ctgccaaaca aagcctaggt tctcacaggg ccttaactta cactcagagt gccccagacc tatcccctca aatcctgact ccacctgtta tatgtagcag ctgtggcaga ccatattccc aagggaatcc tgctgatgag cccctggaga gaagtggggt agccactcgg acaccaagta gaacagatga cactgctcaa gttacctctg attatgaaac caataacaac agtgacagca gtgacattgt acagaatgaa gatgaaacag agtgcctgag agagcctctg aggaaagcat cggcttgcag cacctatgct cctgagacca tgatgtttct ggacaaacca attcttgctc ccgaacctct tgtcatggat aacctggact caattatgga gcagctaaat acttggaatt ttccaatttt tgatttagtg gaaaatatag gaagaaaatg tggccgtatt cttagtcagg tatcttacag actttttgaa gacatgggcc tgtttgaagc ttttaaaatt ccaattaggg aatttatgaa ttattttcat gctttggaga ttggatatag ggatattcct tatcataaca gaatccatgc cactgatgtt ttacatgctg tttggtatct tactacacag cctattccag gcctctcaac tgtgattaat gatcatggtt caaccagtga ttcagattct gacagtggat ttacacatgg acatatggga tatgtattct caaaaacgta taatgtgaca gatgataaat acggatgtct gtctgggaat atccctgcct tggagttgat ggcgctgtat gtggctgcag ccatgcacga ttatgatcat ccaggaagga ctaatgcttt cctggttgca actagtgctc ctcaggcggt gctatataac gatcgttcag ttttggagaa tcatcacgca gctgctgcat ggaatctttt catgtcccgg ccagagtata acttcttaat taaccttgac catgtggaat ttaagcattt ccgtttcctt gtcattgaag caattttggc cactgacctg aagaaacact ttgacttcgt agccaaattt aatggcaagg taaatgatga tgttggaata gattggacca atgaaaatga tcgtctactg gtttgtcaaa tgtgtataaa gttggctgat atcaatggtc cagctaaatg taaagaactc catcttcagt ggacagatgg tattgtcaat gaattttatg aacagggtga tgaagaggcc agccttggat tacccataag ccccttcatg gatcgttctg ctcctcagct ggccaacctt caggaatcct tcatctctca cattgtgggg cctctgtgca actcctatga ttcagcagga ctaatgcctg gaaaatgggt ggaagacagc gatgagtcag gagatactga tgacccagaa gaagaggagg aagaagcacc agcaccaaat gaagaggaaa cctgtgaaaa taatgaatct ccaaaaaaga agactttcaa aaggagaaaa atctactgcc aaataactca gcacctctta cagaaccaca agatgtggaa gaaagtcatt gaagaggagc aacggttggc aggcatagaa aatcaatccc tggaccagac ccctcagtcg cactcttcag aacagatcca ggctatcaag gaagaagaag aagagaaagg gaaaccaaga ggcgaggaga taccaaccca aaagccagac cagtga

Molecular Weight

124,979 Da

OMIM

112410

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PDE3A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE3A. It may not necessarily be applicable to this product.

NCBI GI #

109658585

NCBI GeneID

5139

NCBI Accession #

BC117369

UniProt Secondary Accession #

O60865; Q13348; Q17RD1

UniProt Related Accession #

Q14432

NCBI Official Full Name

Homo sapiens phosphodiesterase 3A, cGMP-inhibited, mRNA

NCBI Official Synonym Full Names

phosphodiesterase 3A

NCBI Official Symbol

PDE3A

NCBI Official Synonym Symbols

HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A

UniProt Protein Name

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

UniProt Synonym Protein Names

Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

Protein Family

cGMP-inhibited 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE3A

UniProt Synonym Gene Names

CGI-PDE A

UniProt Entry Name

PDE3A_HUMAN

NCBI Protein Information

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

NCBI Summary for PDE3A

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

UniProt Comments for PDE3A

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: EC 3.1.4.17; Membrane protein, integral; Nucleotide Metabolism - purine; Membrane protein, multi-pass; Phosphodiesterase

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP-mediated signaling; lipid metabolic process; negative regulation of vascular permeability; positive regulation of vascular permeability

Disease: Hypertension And Brachydactyly Syndrome

Research Articles on PDE3A

1. Chemical proteomics results show that besides known interactors such as 14-3-3 family proteins, PDE3A was found to associate with a PP2A complex composed of a regulatory, scaffold and catalytic subunit.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PDE3A cdna clone

Products by Pathway	Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies	Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
Platelet Homeostasis Pathway antibodies	Platelet Homeostasis Pathway Diagram
Progesterone-mediated Oocyte Maturation Pathway antibodies	Progesterone-mediated Oocyte Maturation Pathway Diagram

Diseases associated with PDE3A cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>18 publications with PDE3A and Cardiovascular Diseases
Thrombosis Antibodies	>16 publications with PDE3A and Thrombosis
Heart Failure Antibodies	>10 publications with PDE3A and Heart Failure
Vascular Diseases Antibodies	>8 publications with PDE3A and Vascular Diseases
Infertility, Female Antibodies	>4 publications with PDE3A and Infertility, Female
Atherosclerosis Antibodies	>3 publications with PDE3A and Atherosclerosis
Hypertension Antibodies	>3 publications with PDE3A and Hypertension
Hypertrophy Antibodies	>2 publications with PDE3A and Hypertrophy
Adenocarcinoma Antibodies	>2 publications with PDE3A and Adenocarcinoma
Necrosis Antibodies	>2 publications with PDE3A and Necrosis