Human PDGFRB cDNA Clone Expression Plasmid – Cat# MBS1267952

PDGFRB cDNA Clone – Platelet-Derived Growth Factor Receptor, Beta Polypeptide (Human)

Name: PDGFRB cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267952
Price: 1430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267952

MBS1267952 is a cDNA clone targeting PDGFRB. More details

$1430 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDGFRB, cDNA Clone

Full Product Name

PDGFRB cDNA Clone

Product Gene Name

PDGFRB cdna clone

Sequence

atgcggcttc cgggtgcgat gccagctctg gccctcaaag gcgagctgct gttgctgtct ctcctgttac ttctggaacc acagatctct cagggcctgg tcgtcacacc cccggggcca gagcttgtcc tcaatgtctc cagcaccttc gttctgacct gctcgggttc agctccggtg gtgtgggaac ggatgtccca ggagccccca caggaaatgg ccaaggccca ggatggcacc ttctccagcg tgctcacact gaccaacctc actgggctag acacgggaga atacttttgc acccacaatg actcccgtgg actggagacc gatgagcgga aacggctcta catctttgtg ccagatccca ccgtgggctt cctccctaat gatgccgagg aactattcat ctttctcacg gaaataactg agatcaccat tccatgccga gtaacagacc cacagctggt ggtgacactg cacgagaaga aaggggacgt tgcactgcct gtcccctatg atcaccaacg tggctttttt ggtatctttg aggacagaag ctacatctgc aaaaccacca ttggggacag ggaggtggat tctgatgcct actatgtcta cagactccag gtgtcatcca tcaacgtctc tgtgaacgca gtgcagactg tggtccgcca gggtgagaac atcaccctca tgtgcattgt gatcgggaat gaggtggtca acttcgagtg gacatacccc cgcaaagaaa gtgggcggct ggtggagccg gtgactgact tcctcttgga tatgccttac cacatccgct ccatcctgca catccccagt gccgagttag aagactcggg gacctacacc tgcaatgtga cggagagtgt gaatgaccat caggatgaaa aggccatcaa catcaccgtg gttgagagcg gctacgtgcg gctcctggga gaggtgggca cactacaatt tgctgagctg catcggagcc ggacactgca ggtagtgttc gaggcctacc caccgcccac tgtcctgtgg ttcaaagaca accgcaccct gggcgactcc agcgctggcg aaatcgccct gtccacgcgc aacgtgtcgg agacccggta tgtgtcagag ctgacactgg ttcgcgtgaa ggtggcagag gctggccact acaccatgcg ggccttccat gaggatgctg aggtccagct ctccttccag ctacagatca atgtccctgt ccgagtgctg gagctaagtg agagccaccc tgacagtggg gaacagacag tccgctgtcg tggccggggc atgccccagc cgaacatcat ctggtctgcc tgcagagacc tcaaaaggtg tccacgtgag ctgccgccca cgctgctggg gaacagttcc gaagaggaga gccagctgga gactaacgtg acgtactggg aggaggagca ggagtttgag gtggtgagca cactgcgtct gcagcacgtg gatcggccac tgtcggtgcg ctgcacgctg cgcaacgctg tgggccagga cacgcaggag gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca cgttacgaga tccgatggaa ggtgattgag tctgtgagct ctgacggcca tgagtacatc tacgtggacc ccatgcagct gccctatgac tccacgtggg agctgccgcg ggaccagctt gtgctgggac gcaccctcgg ctctggggcc tttgggcagg tggtggaggc cacggctcat ggcctgagcc attctcaggc cacgatgaaa gtggccgtca agatgcttaa atccacagcc cgcagcagtg agaagcaagc ccttatgtcg gagctgaaga tcatgagtca ccttgggccc cacctgaacg tggtcaacct gttgggggcc tgcaccaaag gaggacccat ctatatcatc actgagtact gccgctacgg agacctggtg gactacctgc accgcaacaa acacaccttc ctgcagcacc actccgacaa gcgccgcccg cccagcgcgg agctctacag caatgctctg cccgttgggc tccccctgcc cagccatgtg tccttgaccg gggagagcga cggtggctac atggacatga gcaaggacga gtcggtggac tatgtgccca tgctggacat gaaaggagac gtcaaatatg cagacatcga gtcctccaac tacatggccc cttacgataa ctacgttccc tctgcccctg agaggacctg ccgagcaact ttgatcaacg agtctccagt gctaagctac atggacctcg tgggcttcag ctaccaggtg gccaatggca tggagtttct ggcctccaag aactgcgtcc acagagacct ggcggctagg aacgtgctca tctgtgaagg caagctggtc aagatctgtg actttggcct ggctcgagac atcatgcggg actcgaatta catctccaaa ggcagcacct ttttgccttt aaagtggatg gctccggaga gcatcttcaa cagcctctac accaccctga gcgacgtgtg gtccttcggg atcctgctct gggagatctt caccttgggt ggcacccctt acccagagct gcccatgaac gagcagttct acaatgccat caaacggggt taccgcatgg cccagcctgc ccatgcctcc gacgagatct atgagatcat gcagaagtgc tgggaagaga agtttgagat tcggcccccc ttctcccagc tggtgctgct tctcgagaga ctgttgggcg aaggttacaa aaagaagtac cagcaggtgg atgaggagtt tctgaggagt gaccacccag ccatccttcg gtcccaggcc cgcttgcctg ggttccatgg cctccgatct cccctggaca ccagctccgt cctctatact gccgtgcagc ccaatgaggg tgacaacgac tatatcatcc ccctgcctga ccccaaaccc gaggttgctg acgagggccc actggagggt tcccccagcc tagccagctc caccctgaat gaagtcaaca cctcctcaac catctcctgt gacagccccc tggagcccca ggacgaacca gagccagagc cccagcttga gctccaggtg gagccggagc cagagctgga acagttgccg gattcggggt gccctgcgcc tcgggcggaa gcagaggata gcttcctgta g

Molecular Weight

37,412 Da

OMIM

131440

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PDGFRB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDGFRB. It may not necessarily be applicable to this product.

NCBI GI #

21594832

NCBI GeneID

5159

NCBI Accession #

BC032224

UniProt Secondary Accession #

Q8N5L4; B5A957

UniProt Related Accession #

P09619

NCBI Official Full Name

Homo sapiens platelet-derived growth factor receptor, beta polypeptide, mRNA

NCBI Official Synonym Full Names

platelet derived growth factor receptor beta

NCBI Official Symbol

PDGFRB

NCBI Official Synonym Symbols

IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1

UniProt Protein Name

Platelet-derived growth factor receptor beta

UniProt Synonym Protein Names

Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b

Protein Family

Platelet-derived growth factor receptor

UniProt Gene Name

PDGFRB

UniProt Synonym Gene Names

PDGFR; PDGFR1; PDGF-R-beta; PDGFR-beta; PDGFR-1

UniProt Entry Name

PGFRB_HUMAN

NCBI Protein Information

platelet-derived growth factor receptor beta

NCBI Summary for PDGFRB

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]

UniProt Comments for PDGFRB

PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.

Protein type: Membrane protein, integral; EC 2.7.10.1; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: apical plasma membrane; cytoplasm; focal adhesion; intrinsic to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: cardiac myofibril assembly; cell migration; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4; Kosaki Overgrowth Syndrome; Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Premature Aging Syndrome, Penttinen Type

Research Articles on PDGFRB

1. Data suggest that cross-talk between PDGFb-dependent beta-catenin activation and Wnt signaling increases pulmonary artery smooth muscle cell proliferation in idiopathic pulmonary arterial hypertension; proliferation is not increased in normal cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PDGFRB cdna clone

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram

Diseases associated with PDGFRB cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1058 publications with PDGFRB and Neoplasms
Fibrosis Antibodies	>303 publications with PDGFRB and Fibrosis
Cardiovascular Diseases Antibodies	>248 publications with PDGFRB and Cardiovascular Diseases
Brain Diseases Antibodies	>162 publications with PDGFRB and Brain Diseases
Necrosis Antibodies	>143 publications with PDGFRB and Necrosis
Kidney Diseases Antibodies	>142 publications with PDGFRB and Kidney Diseases
Lung Diseases Antibodies	>142 publications with PDGFRB and Lung Diseases
Liver Diseases Antibodies	>137 publications with PDGFRB and Liver Diseases
Inflammation Antibodies	>137 publications with PDGFRB and Inflammation
Hypertension Antibodies	>110 publications with PDGFRB and Hypertension

Organs/Tissues associated with PDGFRB cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>1186 publications with PDGFRB and Vascular
Muscle Antibodies	>855 publications with PDGFRB and Muscle
Blood Antibodies	>679 publications with PDGFRB and Blood
Kidney Antibodies	>294 publications with PDGFRB and Kidney
Lung Antibodies	>270 publications with PDGFRB and Lung
Liver Antibodies	>252 publications with PDGFRB and Liver
Bone Antibodies	>250 publications with PDGFRB and Bone
Brain Antibodies	>246 publications with PDGFRB and Brain
Embryonic Tissue Antibodies	>221 publications with PDGFRB and Embryonic Tissue
Skin Antibodies	>163 publications with PDGFRB and Skin