Human PDHA2 cDNA Clone Expression Plasmid – Cat# MBS1269159

PDHA2 cDNA Clone – Pyruvate Dehydrogenase (Lipoamide) Alpha 2 (Human)

Name: PDHA2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269159
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269159

MBS1269159 is a cDNA clone targeting PDHA2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDHA2, cDNA Clone

Full Product Name

PDHA2 cDNA Clone

Product Gene Name

PDHA2 cdna clone

Sequence

ATGCTGGCCG CCTTCATCTC CCGCGTGTTG AGGCGAGTTG CCCAGAAATC AGCTCGCAGA GTGCTGGTGG CATCCCGTAA CTCCTCAAAT GACGCTACAT TTGAAATTAA GAAATGTGAT CTTTATCTGT TGGAAGAGGG TCCCCCTGTC ACTACAGTGC TCACTAGGGC GGAGGGGCTT AAATACTACA GGATGATGCT GACTGTTCGC CGCATGGAAT TGAAGGCAGA TCAGCTGTAC AAACAGAAAT TCATTCGCGG TTTCTGTCAC CTGTGCGATG GTCAGGAAGC TTGTTGCGTG GGCCTTGAGG CCGGCATAAA CCCCTCGGAT CACGTCATTA CATCCTATAG GGCTCATGGT GTGTGCTATA CTCGGGGACC TTCTGTCCGA TCCATTCTCG CAGAGCTGAC GGGAAGAAGA GGAGGTTGTG CTAAAGGAAA AGGAGGATCG ATGCATATGT ATACCAAGAA CTTCTATGGG GGCAATGGCA TCGTCGGTGC ACAGGGCCCC CTGGGCGCTG GCATTGCTCT GGCCTGTAAA TATAAAGGAA ACGATGAGAT CTGTTTGACT TTATATGGGG ATGGCGCTGC GAATCAGGGG CAGATAGCCG AAGCTTTCAA TATGGCAGCT TTATGGAAAT TACCTTGTGT TTTCATCTGT GAGAATAACC TATATGGAAT GGGAACATCT ACTGAGAGAG CAGCAGCCAG CCCTGATTAC TACAAGAGGG GCAATTTTAT CCCTGGGCTA AAGGTCGATG GAATGGATGT TCTGTGTGTT CGTGAGGCAA CAAAATTTGC AGCTAACTAC TGTAGATCTG GAAAGGGGCC CATACTGATG GAGCTGCAAA CCTACCGTTA TCATGGACAC AGTATGAGTG ATCCTGGAGT CAGTTATCGT ACACGAGAAG AAATTCAGGA AGTAAGAAGT AAGAGGGATC CTATAATAAT TCTCCAAGAT AGAATGGTAA ACAGCAAGCT CGCCACTGTG GAAGAATTAA AGGAAATTGG GGCTGAGGTG AGGAAAGAAA TTGATGATGC TGCCCAGTTT GCTACCACTG ATCCTGAGCC ACATTTGGAA GAATTAGGCC ATCACATCTA CAGCAGTGAT TCATCTTTTG AAGTTCGTGG TGCAAATCCA TGGATCAAGT TTAAGTCCGT CAGTTAA

Molecular Weight

42,933 Da

OMIM

179061

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PDHA2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDHA2. It may not necessarily be applicable to this product.

NCBI GI #

45219780

NCBI GeneID

5161

NCBI Accession #

BC066953

UniProt Secondary Accession #

Q0VDI5; Q4VC02; Q6NXQ1; B2R9Q3

UniProt Related Accession #

P29803

NCBI Official Full Name

Homo sapiens pyruvate dehydrogenase (lipoamide) alpha 2, mRNA

NCBI Official Synonym Full Names

pyruvate dehydrogenase (lipoamide) alpha 2

NCBI Official Symbol

PDHA2

NCBI Official Synonym Symbols

PDHAL

UniProt Protein Name

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

UniProt Synonym Protein Names

PDHE1-A type II

Protein Family

Pyruvate dehydrogenase E1 component

UniProt Gene Name

PDHA2

UniProt Synonym Gene Names

PDHAL

UniProt Entry Name

ODPAT_HUMAN

NCBI Protein Information

pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

UniProt Comments for PDHA2

PDHA2: a testis-specific mitochondrial matrix enzyme that catalyzes the oxidative decarboxylation of pyruvate, producing acetyl-CoA and CO2. A key enzyme in controlling the balance between lipid and glucose oxidation depending on substrate availability. The pyruvate dehydrogenase (PDH) holoenzyme is a multi-enzyme complex (PDHC) that contains 20-30 copies of pyruvate decarboxylase tetramers (2 alpha:2 beta)(E1), 60 copies of dihydrolipoamide acetyltransferase (E2), six homodimers of dihydrolipoamide dehydrogenase (E3), plus E3 binding proteins. The activity of PDH is tightly regulated by phosphorylation. The phosphorylation of at least one of three specific serine residues in E1 subunit by PDHK inactivates the PDHC, while dephosphorylation by PDP restores its activity. Expressed in postmeiotic spermatogenic cells.

Protein type: Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; EC 1.2.4.1; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 4q22-q23

Cellular Component: mitochondrion; nucleus

Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity

Biological Process: pyruvate metabolic process

Research Articles on PDHA2

1. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PDHA2 cdna clone

Products by Pathway	Pathway Diagram
Acetylcholine Synthesis Pathway antibodies	Acetylcholine Synthesis Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Citrate Cycle (TCA Cycle) Pathway antibodies	Citrate Cycle (TCA Cycle) Pathway Diagram
Citrate Cycle (TCA Cycle) Pathway antibodies	Citrate Cycle (TCA Cycle) Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Glycolysis And Gluconeogenesis Pathway antibodies	Glycolysis And Gluconeogenesis Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram
Pyruvate Metabolism Pathway antibodies	Pyruvate Metabolism Pathway Diagram

Organs/Tissues associated with PDHA2 cdna clone

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>7 publications with PDHA2 and Testis