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PIAS1 cDNA Clone – Protein Inhibitor of Activated STAT, 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266110

MBS1266110 is a cDNA clone targeting PIAS1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PIAS1, cDNA Clone
Full Product Name
PIAS1 cDNA Clone
Product Gene Name
PIAS1 cdna clone
Sequence
ATGGCGGACA GTGCGGAACT AAAGCAAATG GTTATGAGCC TTAGAGTTTC TGAACTCCAA GTACTGTTGG GCTACGCCGG GAGAAACAAG CACGGACGCA AACACGAACT TCTCACAAAA GCCCTGCATT TGCTAAAGGC TGGCTGTAGT CCTGCTGTGC AAATGAAAAT TAAGGAACTC TATAGGCGGC GGTTCCCACA GAAAATCATG ACGCCTGCAG ACTTGTCCAT CCCCAACGTA CATTCAAGTC CTATGCCAGC AACTTTGTCT CCATCTACCA TTCCACAACT CACTTACGAT GGTCACCCTG CATCATCGCC ATTACTCCCT GTTTCTCTTC TGGGACCTAA ACATGAACTG GAACTCCCAC ATCTTACATC AGCTCTTCAC CCAGTCCATC CGGATATAAA ACTTCAAAAA TTACCATTTT ATGATTTACT GGATGAACTG ATAAAACCCA CCAGTCTAGC ATCAGACAAC AGTCAGCGCT TTCGAGAAAC CTGTTTTGCA TTTGCCTTGA CACCACAACA AGTGCAGCAA ATCAGTAGTT CCATGGATAT TTCTGGGACC AAATGTGACT TCACAGTACA GGTCCAGTTA AGGTTTTGTT TATCAGAAAC CAGTTGTCCA CAAGAAGATC ACTTCCCACC CAATCTTTGT GTGAAAGTGA ATACAAAACC TTGCAGCCTT CCAGGTTACC TTCCACCTAC AAAAAATGGC GTGGAACCAA AGCGACCCAG CCGACCAATT AATATCACCT CACTTGTCCG ACTGTCCACA ACAGTACCAA ACACGATTGT TGTTTCTTGG ACTGCAGAAA TTGGAAGAAA CTATTCCATG GCAGTATATC TTGTAAAACA GTTGTCCTCA ACAGTTCTTC TTCAGAGGTT ACGAGCAAAG GGAATAAGGA ATCCGGATCA TTCTAGAGCT TTAATTAAAG AGAAGTTGAC TGCGGATCCA GACAGTGAAA TAGCTACAAC CAGCCTAAGG GTTTCTCTAC TATGTCCACT TGGTAAAATG CGGCTGACAA TTCCGTGTCG GGCCCTTACA TGTTCTCATC TACAATGTTT TGACGCAACT CTTTACATTC AGATGAATGA GAAAAAACCA ACCTGGGTTT GTCCTGTCTG TGATAAGAAG GCTCCATATG AACACCTTAT TATTGATGGC TTGTTTATGG AAATCCTAAA GTACTGTACA GACTGTGATG AAATACAATT TAAGGAGGAT GGCACTTGGG CACCGATGAG ATCAAAAAAG GAAGTACAGG AAGTTTCTGC CTCTTACAAT GGAGTCGATG GATGCTTGAG CTCCACATTG GAGCATCAGG TAGCGTCTCA CCACCAGTCC TCAAATAAAA ACAAGAAAGT AGAAGTGATT GACCTAACCA TAGACAGTTC ATCTGATGAA GAGGAAGAAG AGCCATCTGC CAAGAGGACC TGTCCTTCCC TATCTCCCAC ATCACCACTA AATAATAAAG GCATTTTAAG TCTTCCACAT CAAGCATCTC CAGTATCCCG CACCCCAAGC CTTCCTGCTG TAGACACAAG CTACATTAAT ACCTCCCTCA TCCAAGACTA TAGGCATCCT TTCCACATGA CACCCATGCC TTACGACTTA CAAGGATTAG ATTTCTTTCC TTTCTTATCA GGAGACAATC AGCATTACAA CACCTCCTTG CTTGCCGCTG CAGCAGCAGC AGTTTCAGAT GATCAAGACC TCCTACACTC GTCTCGGTTT TTCCCGTATA CCTCCTCACA GATGTTTCTT GATCAGTTAA GTGCAGGAGG CAGTACTTCT CTGCCAACCA CCAATGGAAG CAGTAGTGGC AGTAACAGCA GCCTGGTTTC TTCCAACAGC CTAAGGGAAA GCCATAGCCA CACCGTCACA AACAGGAGCA GCACGGACAC GGCATCCATC TTTGGCATCA TACCAGACAT TATTTCATTG GACTGA
Molecular Weight
36,204 Da
OMIM
603566
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIAS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIAS1. It may not necessarily be applicable to this product.

NCBI GI #
112292465
NCBI GeneID
8554
NCBI Accession #
BC121797
UniProt Secondary Accession #
Q147X4; Q99751; Q9UN02; B2RB67; B3KSY9; C5J4B4
UniProt Related Accession #
O75925
NCBI Official Full Name
Homo sapiens protein inhibitor of activated STAT, 1, mRNA
NCBI Official Synonym Full Names
protein inhibitor of activated STAT 1
NCBI Official Symbol
PIAS1
NCBI Official Synonym Symbols
GBP; ZMIZ3; DDXBP1; GU/RH-II
UniProt Protein Name
E3 SUMO-protein ligase PIAS1
UniProt Synonym Protein Names
DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein
Protein Family
E3 SUMO-protein ligase
UniProt Gene Name
PIAS1
UniProt Synonym Gene Names
DDXBP1; GBP
UniProt Entry Name
PIAS1_HUMAN
NCBI Protein Information
E3 SUMO-protein ligase PIAS1

NCBI Summary for PIAS1

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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UniProt Comments for PIAS1

PIAS1: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Interacts with NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation. Interacts with DDX21, CSRP2, AXIN1, JUN, UBE2I, SUMO1, SATB2, PLAG1, TP53 and STAT1 (dimer), following IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Interacts with STAT1. Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with PTK2/FAK1; the interaction promotes its sumoylation. Interacts with DDX5. Expressed in numerous tissues with highest level in testis. Belongs to the PIAS family.

Protein type: EC 6.3.2.-; Transcription, coactivator/corepressor; SUMO conjugating system; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 15q

Cellular Component: nucleoplasm; nucleus; PML body

Molecular Function: enzyme binding; protein binding; SUMO ligase activity; transcription corepressor activity

Biological Process: JAK-STAT cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein sumoylation; protein sumoylation; regulation of cell proliferation
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Research Articles on PIAS1

1. PIAS1 enhances p300 recruitment to c-Myb-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIAS1 cdna clone

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with PIAS1 cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with PIAS1 and Neoplasms
 Inflammation Antibodies  >14 publications with PIAS1 and Inflammation
 Necrosis Antibodies  >11 publications with PIAS1 and Necrosis
 Liver Diseases Antibodies  >6 publications with PIAS1 and Liver Diseases
 Lung Diseases Antibodies  >6 publications with PIAS1 and Lung Diseases
 Skin Diseases Antibodies  >6 publications with PIAS1 and Skin Diseases
 Adenocarcinoma Antibodies  >5 publications with PIAS1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >4 publications with PIAS1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with PIAS1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >4 publications with PIAS1 and Lung Neoplasms

Organs/Tissues associated with PIAS1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >19 publications with PIAS1 and Muscle
 Blood Antibodies  >16 publications with PIAS1 and Blood
 Liver Antibodies  >11 publications with PIAS1 and Liver
 Prostate Antibodies  >8 publications with PIAS1 and Prostate
 Testis Antibodies  >8 publications with PIAS1 and Testis
 Brain Antibodies  >8 publications with PIAS1 and Brain
 Heart Antibodies  >7 publications with PIAS1 and Heart
 Embryonic Tissue Antibodies  >7 publications with PIAS1 and Embryonic Tissue
 Lung Antibodies  >6 publications with PIAS1 and Lung
 Vascular Antibodies  >5 publications with PIAS1 and Vascular
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