Human PIGM cDNA Clone Expression Plasmid – Cat# MBS1266404

PIGM cDNA Clone – Phosphatidylinositol Glycan Anchor Biosynthesis, Class M (Human)

Name: PIGM cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266404
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266404

MBS1266404 is a cDNA clone targeting PIGM. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PIGM, cDNA Clone

Full Product Name

PIGM cDNA Clone

Product Gene Name

PIGM cdna clone

Sequence

atgggctcca ccaagcactg gggcgaatgg ctcctgaact tgaaggtggc tccagccggc gtctttggtg tggcctttct agccagagtc gccctggttt tctatggcgt cttccaggac cggaccctgc acgtgaggta tacggacatc gactaccagg tcttcaccga cgccgcgcgc ttcgtcacgg aggggcgctc gccttacctg agagccacgt accgttacac cccgctgctg ggttggctcc tcactcccaa catctacctc agcgagctct ttggaaagtt tctcttcatc agctgcgacc tcctcaccgc tttcctctta taccgcctgc tgctgctgaa ggggctgggg cgccgccagg cttgtggcta ctgtgtcttt tggcttctta accccctgcc tatggcagta tccagccgcg gtaatgcgga ctctattgtc gcctccctgg tcctgatggt cctctacttg ataaagaaaa gactcgtcgc gtgtgcagct gtattctatg gtttcgcggt gcatatgaag atatatccag tgacttacat ccttcccata accctccacc tgcttccaga tcgcgacaat gacaaaagcc tccgtcaatt ccggtacact ttccaggctt gtttgtacga gctcctgaaa aggctgtgta atcgggctgt gctgctgttt gtagcagttg ctggactcac gttttttgcc ctgagctttg gtttttacta tgagtacggc tgggaatttt tggaacacac ctacttttat cacctgacta ggcgggatat ccgtcacaac ttttctccgt acttctacat gctgtatttg actgcagaga gcaagtggag tttttccctg ggaattgctg cattcctgcc acagctcatc ttgctttcag ctgtgtcttt cgcctattac agagacctcg ttttttgttg ttttcttcat acgtccattt ttgtgacttt taacaaagtc tgcacctccc agtactttct ttggtacctc tgcttactgc ctcttgtgat gccactagtc agaatgcctt ggaaaagagc tgtagttctc ctaatgttat ggtttatagg gcaggccatg tggctggctc ctgcctatgt tctagagttt caaggaaaga acacctttct gtttatttgg ttagctggtt tgttctttct tcttatcaat tgttccatcc tgattcaaat tatttcccat tacaaagaag aacccctgac agagagaatc aaatatgact ag

Molecular Weight

49,460 Da

OMIM

610273

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIGM cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGM. It may not necessarily be applicable to this product.

NCBI GI #

18044728

NCBI GeneID

93183

NCBI Accession #

BC019865

UniProt Related Accession #

Q9H3S5

NCBI Official Full Name

Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class M, mRNA

NCBI Official Synonym Full Names

phosphatidylinositol glycan anchor biosynthesis class M

NCBI Official Symbol

PIGM

NCBI Official Synonym Symbols

GPI-MT-I

UniProt Protein Name

GPI mannosyltransferase 1

UniProt Synonym Protein Names

GPI mannosyltransferase I; GPI-MT-I; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M

Protein Family

Probable NAD(P)H nitroreductase

UniProt Gene Name

PIGM

UniProt Synonym Gene Names

GPI-MT-I; PIG-M

UniProt Entry Name

PIGM_HUMAN

NCBI Protein Information

GPI mannosyltransferase 1

NCBI Summary for PIGM

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

UniProt Comments for PIGM

PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family.

Protein type: Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 2.4.1.-; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: endoplasmic reticulum membrane

Biological Process: preassembly of GPI anchor in ER membrane

Disease: Glycosylphosphatidylinositol Deficiency

Research Articles on PIGM

1. B cells but not red cells are glycosylphosphatidylinositol deficient in PIGM-associated inherited glycosylphosphatidylinositol deficiency, caused by a core promoter mutation that abrogates Sp1 binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIGM cdna clone

Products by Pathway	Pathway Diagram
GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies	GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies	GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies	Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway antibodies	Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway Diagram

Diseases associated with PIGM cdna clone

Disease Name	Pubmed Publications
Seizures Antibodies	>4 publications with PIGM and Seizures
Brain Diseases Antibodies	>3 publications with PIGM and Brain Diseases
Neurobehavioral Manifestations Antibodies	>3 publications with PIGM and Neurobehavioral Manifestations
Glycosylphosphatidylinositol deficiency Antibodies	>2 publications with PIGM and Glycosylphosphatidylinositol deficiency
Cardiovascular Diseases Antibodies	>2 publications with PIGM and Cardiovascular Diseases
Breast Neoplasms Antibodies	>1 publications with PIGM and Breast Neoplasms
Intestinal Neoplasms Antibodies	>1 publications with PIGM and Intestinal Neoplasms
Disease Models, Animal Antibodies	>1 publications with PIGM and Disease Models, Animal
Proteinuria Antibodies	>1 publications with PIGM and Proteinuria
Necrosis Antibodies	>1 publications with PIGM and Necrosis

Organs/Tissues associated with PIGM cdna clone

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>3 publications with PIGM and Ovary
Eye Antibodies	>2 publications with PIGM and Eye
Liver Antibodies	>2 publications with PIGM and Liver
Connective Tissue Antibodies	>1 publications with PIGM and Connective Tissue
Spleen Antibodies	>1 publications with PIGM and Spleen
Kidney Antibodies	>1 publications with PIGM and Kidney
Intestine Antibodies	>1 publications with PIGM and Intestine