Human PIGV cDNA Clone Expression Plasmid – Cat# MBS1277715

PIGV cDNA Clone – Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (Human)

Name: PIGV cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277715
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277715

MBS1277715 is a cDNA clone targeting PIGV. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PIGV, cDNA Clone

Full Product Name

PIGV cDNA Clone

Product Gene Name

PIGV cdna clone

Sequence

atgtggcccc aggacccatc ccggaaggag gtgctgaggt ttgcagtcag ctgccgtatc ctgactctga tgctgcaggc cctcttcaat gccatcatcc cagatcacca tgcagaagcc ttctctcctc ctcgcctggc cccctcaggc tttgtggacc aactcgtgga aggtcttctg ggcggcctgt ctcactggga tgctgaacac ttcttgttca ttgctgagca tggctacctg tatgagcaca actttgcctt ctttcctggt ttccccttgg ccctgctggt ggggactgaa ctgttgagac ccttacgggg gttactgagt ctacgcagtt gcctgctgat ttcggtagca tcactcaatt tcttgttctt catgttggct gcagttgcac ttcatgacct gggttgtctg gttttgcact gtccccacca gtccttttat gcagctctgc ttttctgtct cagccctgcc aatgtcttcc tggcagctgg ttactcagaa gctttgtttg ccctcctgac attcagtgcc atggggcagc tggagagggg ccgagtctgg actagtgtac tcctctttgc ctttgccact ggggtacgct ccaacgggct ggtcagtgtt ggcttcctca tgcattctca atgccaaggc tttttctctt ctctaacgat gctgaatcct ctgagacagc tctttaagct gatggcctct ctgtttctgt cggtgttcac acttggcctt ccctttgccc tctttcagta ttatgcctac acccaattct gtctgccagg ctcagcccgc cccattcctg agcctttggt acagttagct gtagacaagg gctaccggat tgcagaggga aatgaaccgc cttggtgctt ctgggatgtt ccactaatat acagctatat ccaggatgtc tactggaatg ttggcttttt gaaatactat gagctcaagc aggtgcccaa ttttctactg gctgcaccag tggctatact ggttgcctgg gcaacttgga catacgtgac cactcaccct tggctctgcc ttacacttgg gctgcaaagg agcaagaaca ataagaccct agagaagccc gatcttggat tcctcagtcc tcaggtgttt gtgtacgtgg tccacgctgc agtgctgctg ctgtttggag gtctgtgcat gcatgttcag gttctcacca ggtttttggg ctcctccact cctattatgt actggtttcc agctcacttg cttcaggatc aagagccgct gttgagatcc ttaaagactg tgccttggaa gcctcttgca gaggactccc caccaggaca aaaggtcccc agaaatccta tcatgggact tttgtatcac tggaaaacct gttctccagt cacacgatac attctaggct acttcctgac ttactggctc ctgggactac tcctacattg caacttcctg ccttggacat ga

Molecular Weight

55,713 Da

OMIM

239300

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIGV cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGV. It may not necessarily be applicable to this product.

NCBI GI #

15488875

NCBI GeneID

55650

NCBI Accession #

BC013568

UniProt Secondary Accession #

Q5JYG7; Q5JYG8; Q5JYG9; Q9NX26; D3DPL2

UniProt Related Accession #

Q9NUD9

NCBI Official Full Name

Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class V, mRNA

NCBI Official Synonym Full Names

phosphatidylinositol glycan anchor biosynthesis class V

NCBI Official Symbol

PIGV

NCBI Official Synonym Symbols

PIG-V; HPMRS1; GPI-MT-II

UniProt Protein Name

GPI mannosyltransferase 2

UniProt Synonym Protein Names

GPI mannosyltransferase II; GPI-MT-II; Phosphatidylinositol-glycan biosynthesis class V protein; PIG-V

Protein Family

GPI mannosyltransferase

UniProt Gene Name

PIGV

UniProt Synonym Gene Names

GPI-MT-II; PIG-V

UniProt Entry Name

PIGV_HUMAN

NCBI Protein Information

GPI mannosyltransferase 2

NCBI Summary for PIGV

This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia mental retardation syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

UniProt Comments for PIGV

PIGV: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Defects in PIGV are the cause of hyperphosphatasia with mental retardation type 1 (HPMRS1). It is a syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges. Belongs to the PIGV family.

Protein type: Membrane protein, multi-pass; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 2.4.1.-; Membrane protein, integral; Transferase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: endoplasmic reticulum membrane; mannosyltransferase complex

Molecular Function: glycolipid mannosyltransferase activity; mannosyltransferase activity

Biological Process: GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane

Disease: Hyperphosphatasia With Mental Retardation Syndrome 1

Research Articles on PIGV

1. Data indicate that mannosyltransferases PIGV mutations are the major cause of hyperphosphatasia-mental retardation syndrome (HPMRS) which displays a broad clinical variability regarding associated malformations and growth patterns.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIGV cdna clone

Products by Pathway	Pathway Diagram
GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies	GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
GPI-anchor Biosynthesis, Core Oligosaccharide Pathway antibodies	GPI-anchor Biosynthesis, Core Oligosaccharide Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies	Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway antibodies	Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway Diagram

Diseases associated with PIGV cdna clone

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>6 publications with PIGV and Mental Disorders
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 1 Antibodies	>3 publications with PIGV and HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 1
Anemia, Hemolytic Antibodies	>1 publications with PIGV and Anemia, Hemolytic
Hematologic Diseases Antibodies	>1 publications with PIGV and Hematologic Diseases