Human PIK3CB cDNA Clone Expression Plasmid – Cat# MBS1271318

PIK3CB cDNA Clone – Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide (Human)

Name: PIK3CB cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1271318
Price: 1380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271318

MBS1271318 is a cDNA clone targeting PIK3CB. More details

$1380 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PIK3CB, cDNA Clone

Full Product Name

PIK3CB cDNA Clone

Product Gene Name

PIK3CB cdna clone

Sequence

ATGTGCTTCA GTTTCATAAT GCCTCCTGCT ATGGCAGACA TCCTTGACAT CTGGGCGGTG GATTCACAGA TAGCATCTGA TGGCTCCATA CCTGTGGATT TCCTTTTGCC CACTGGGATT TATATCCAGT TGGAGGTACC TCGGGAAGCT ACCATTTCTT ATATTAAGCA GATGTTATGG AAGCAAGTTC ACAATTACCC AATGTTCAAC CTCCTTATGG ATATTGACTC CTATATGTTT GCATGTGTGA ATCAGACTGC TGTATATGAG GAGCTTGAAG ATGAAACACG AAGACTCTGT GATGTCAGAC CTTTTCTTCC AGTTCTCAAA TTAGTGACAA GAAGTTGTGA CCCAGGGGAA AAATTAGACT CAAAAATTGG AGTCCTTATA GGAAAAGGTC TGCATGAATT TGATTCCTTG AAGGATCCTG AAGTAAATGA ATTTCGAAGA AAAATGCGCA AATTCAGCGA GGAAAAAATC CTGTCACTTG TGGGATTGTC TTGGATGGAC TGGCTAAAAC AAACATATCC ACCAGAGCAT GAACCATCCA TCCCTGAAAA CTTAGAAGAT AAACTTTATG GGGGAAAGCT CATCGTAGCT GTTCATTTTG AAAACTGCCA GGACGTGTTT AGCTTTCAAG TGTCTCCTAA TATGAATCCT ATCAAAGTAA ATGAATTGGC AATCCAAAAA CGTTTGACTA TTCATGGGAA GGAAGATGAA GTTAGCCCCT ATGATTATGT GTTGCAAGTC AGCGGGAGAG TAGAATATGT TTTTGGTGAT CATCCACTAA TTCAGTTCCA GTATATCCGG AACTGTGTGA TGAACAGAGC CCTGCCCCAT TTTATACTTG TGGAATGCTG CAAGATCAAG AAAATGTATG AACAAGAAAT GATTGCCATA GAGGCTGCCA TAAATCGAAA TTCATCTAAT CTTCCTCTTC CATTACCACC AAAGAAAACA CGAATTATTT CTCATGTTTG GGAAAATAAC AACCCTTTCC AAATTGTCTT GGTTAAGGGA AATAAACTTA ACACAGAGGA AACTGTAAAA GTTCATGTCA GGGCTGGTCT TTTTCATGGT ACTGAGCTCC TGTGTAAAAC CATCGTAAGC TCAGAGGTAT CAGGGAAAAA TGATCATATT TGGAATGAAC CACTGGAATT TGATATTAAT ATTTGTGACT TACCAAGAAT GGCTCGATTA TGTTTTGCTG TTTATGCAGT TTTGGATAAA GTAAAAACGA AGAAATCAAC GAAAACTATT AATCCCTCTA AATATCAGAC CATCAGGAAA GCTGGAAAAG TGCATTATCC TGTAGCGTGG GTAAATACGA TGGTTTTTGA CTTTAAAGGA CAATTGAGAA CTGGAGACAT AATATTACAC AGCTGGTCTT CATTTCCTGA TGAACTCGAA GAAATGTTGA ATCCAATGGG AACTGTTCAA ACAAATCCAT ATACTGAAAA TGCAACAGCT TTGCATGTTA AATTTCCAGA GAATAAAAAA CAACCTTATT ATTACCCTCC CTTCGATAAG ATTATTGAAA AGGCAGCTGA GATTGCAAGC AGTGATAGTG CTAATGTGTC AAGTCGAGGT GGAAAAAAGT TTCTTCCTGT ATTGAAAGAA ATCTTGGACA GGGATCCCTT GTCTCAACTG TGTGAAAATG AAATGGATCT TATTTGGACT TTGCGACAAG ACTGCCGAGA GATTTTCCCA CAATCACTGC CAAAATTACT GCTGTCAATC AAGTGGAATA AACTTGAGGA TGTTGCTCAG CTTCAGGCGC TGCTTCAGAT TTGGCCTAAA CTGCCCCCCC GGGAGGCCCT AGAGCTTCTG GATTTCAACT ATCCAGACCA GTACGTTCGA GAATATGCTG TAGGCTGCCT GCGACAGATG AGTGATGAAG AACTTTCTCA ATATCTTTTA CAACTGGTGC AAGTGTTAAA ATATGAGCCT TTTCTTGATT GTGCCCTCTC TAGATTCCTA TTAGAAAGAG CACTTGGTAA TCGGAGGATA GGGCAGTTTC TATTTTGGCA TCTTAGGTCA GAAGTGCACA TTCCTGCTGT CTCAGTACAA TTTGGTGTCA TCCTTGAAGC ATACTGCCGG GGAAGTGTGG GGCACATGAA AGTGCTTTCT AAGCAGGTTG AAGCACTCAA TAAGTTAAAA ACTTTAAATA GTTTAATCAA ACTGAATGCC GTGAAGTTAA ACAGAGCCAA AGGGAAGGAG GCCATGCATA CCTGTTTAAA ACAGAGTGCT TACCGGGAAG CCCTCTCTGA CCTGCAGTCA CCCCTGAACC CATGTGTTAT CCTCTCAGAA CTCTATGTTG AAAAGTGCAA ATACATGGAT TCCAAAATGA AGCCTTTGTG GCTGGTATAC AATAACAAGG TATTTGGTGA GGATTCAGTT GGAGTGATTT TTAAAAATGG TGATGATTTA CGACAGGATA TGTTGACACT CCAAATGTTG CGCTTGATGG ATTTACTCTG GAAAGAAGCT GGTTTGGATC TTCGGATGTT GCCTTATGGC TGTTTAGCAA CAGGAGATCG CTCTGGCCTC ATTGAAGTTG TGAGCACCTC TGAAACAATT GCTGACATTC AGCTGAACAG TAGCAATGTG GCTGCTGCAG CAGCCTTCAA CAAAGATGCC CTTCTGAACT GGCTTAAAGA ATACAACTCT GGGGATGACC TGGACCGAGC CATTGAGGAA TTTACACTGT CCTGTGCTGG CTACTGTGTA GCTTCTTATG TCCTTGGGAT TGGTGACAGA CATAGTGACA ACATCATGGT CAAAAAAACT GGCCAGCTCT TCCACATTGA CTTTGGACAT ATTCTTGGAA ATTTCAAATC TAAGTTTGGC ATTAAAAGGG AGCGAGTGCC TTTTATTCTT ACCTATGATT TCATCCATGT CATTCAACAA GGAAAAACAG GAAATACAGA AAAGTTTGGC CGGTTCCGCC AGTGTTGTGA GGATGCATAT CTGATTTTAC GACGGCATGG GAATCTCTTC ATCACTCTCT TTGCGCTGAT GTTGACTGCA GGGCTTCCTG AACTCACATC AGTCAAAGAT ATACAGTATC TTAAGGACTC TCTTGCATTA GGGAAGAGTG AAGAAGAAGC ACTCAAACAG TTTAAGCAAA AATTTGATGA GGCGCTCAGG GAAAGCTGGA CTACTAAAGT GAACTGGATG GCCCACACAG TTCGGAAAGA CTACAGATCT TAA

Molecular Weight

122,762 Da

OMIM

602925

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIK3CB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIK3CB. It may not necessarily be applicable to this product.

NCBI GI #

89365912

NCBI GeneID

5291

NCBI Accession #

BC114432

UniProt Secondary Accession #

Q24JU2; D3DNF0

UniProt Related Accession #

P42338

NCBI Official Full Name

Homo sapiens phosphoinositide-3-kinase, catalytic, beta polypeptide, mRNA

NCBI Official Synonym Full Names

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

NCBI Official Symbol

PIK3CB

NCBI Official Synonym Symbols

PI3K; PIK3C1; P110BETA; PI3KBETA

UniProt Protein Name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

UniProt Synonym Protein Names

Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta

Protein Family

Phosphatidylinositol 4,5-bisphosphate 3-kinase

UniProt Gene Name

PIK3CB

UniProt Synonym Gene Names

PIK3C1; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta

UniProt Entry Name

PK3CB_HUMAN

NCBI Protein Information

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

NCBI Summary for PIK3CB

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

UniProt Comments for PIK3CB

PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: cytosol; intercellular bridge; nucleolus; nucleus; phosphoinositide 3-kinase complex; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding

Biological Process: activation of MAPK activity; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet activation; positive regulation of autophagy; regulation of cell-matrix adhesion; regulation of phosphoinositide 3-kinase cascade; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway

Research Articles on PIK3CB

1. Our findings provide new insight into the genetic mechanisms underlying PI3K pathway activation in human tumors and indicate that PIK3Cb(D1067V) is a rational therapeutic target in certain cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIK3CB cdna clone

Products by Pathway	Pathway Diagram
3-phosphoinositide Biosynthesis Pathway antibodies	3-phosphoinositide Biosynthesis Pathway Diagram
3-phosphoinositide Biosynthesis Pathway antibodies	3-phosphoinositide Biosynthesis Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram

Diseases associated with PIK3CB cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>129 publications with PIK3CB and Neoplasms
Inflammation Antibodies	>28 publications with PIK3CB and Inflammation
Breast Neoplasms Antibodies	>24 publications with PIK3CB and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>24 publications with PIK3CB and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>14 publications with PIK3CB and Neoplasms, Experimental
Drug Toxicity Antibodies	>10 publications with PIK3CB and Drug Toxicity
Necrosis Antibodies	>10 publications with PIK3CB and Necrosis
Neoplasm Invasiveness Antibodies	>9 publications with PIK3CB and Neoplasm Invasiveness
Lung Neoplasms Antibodies	>7 publications with PIK3CB and Lung Neoplasms
Hypertrophy Antibodies	>7 publications with PIK3CB and Hypertrophy