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PMEPA1 cDNA Clone – Prostate Transmembrane Protein, Androgen Induced 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278656

MBS1278656 is a cDNA clone targeting PMEPA1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PMEPA1, cDNA Clone
Full Product Name
PMEPA1 cDNA Clone
Product Gene Name
PMEPA1 cdna clone
Sequence
ATGGCGGAGC TGGAGTTTGT TCAGATCATC ATCATCGTGG TGGTGATGAT GGTGATGGTG GTGGTGATCA CGTGCCTGCT GAGCCACTAC AAGCTGTCTG CACGGTCCTT CATCAGCTGG CACAGCCAGG GGCGGAGGAG AGAAGATGCC CTGTCCTCAG AAGGATGCCT GTGGCCCTCG GAGAGCACAG TGTCAGGCAA CGGAATCCCA GAGCCGCAGG TCTACGCCCC GCCTCGGCCC ACCGACCGCC TGGCCGTGCC GCCCTTCGCC CAGCGGGAGC GCTTCCACCG CTTCCAGCCC ACCTATCCGT ACCTGCAGCA CGAGATCGAC CTGCCGCCCA CCATCTCGCT GTCGGACGGG GAGGAGCCCC CACCCTACCA GGGCCCCTGC ACCCTCCAGC TTCGGGACCC CGAGCAGCAG CTGGAACTGA ACCGGGAGTC GGTGCGCGCA CCCCCAAACA GAACCATCTT CGACAGTGAC CTGATGGATA GTGCCAGGCT GGGCGGCCCC TGCCCCCCCA GCAGTAACTC GGGCATCAGC GCCACGTGCT ACGGCAGCGG CGGGCGCATG GAGGGGCCGC CGCCCACCTA CAGCGAGGTC ATCGGCCACT ACCCGGGGTC CTCCTTCCAG CACCAGCAGA GCAGTGGGCC GCCCTCCTTG CTGGAGGGGA CCCGGCTCCA CCACACACAC ATCGCGCCCC TAGAGAGCGC AGCCATCTGG AGCAAAGAGA AGGATAAACA GAAAGGACAC CCTCTCTAG
Molecular Weight
26,201 Da
OMIM
606564
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PMEPA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PMEPA1. It may not necessarily be applicable to this product.

NCBI GI #
51593770
NCBI GeneID
56937
NCBI Accession #
BC080635
UniProt Secondary Accession #
Q5TDR6; Q8NER4; Q96B72; Q9UJD3
UniProt Related Accession #
Q969W9
NCBI Official Full Name
Homo sapiens prostate transmembrane protein, androgen induced 1, mRNA
NCBI Official Synonym Full Names
prostate transmembrane protein, androgen induced 1
NCBI Official Symbol
PMEPA1
NCBI Official Synonym Symbols
STAG1; TMEPAI
UniProt Protein Name
Protein TMEPAI
UniProt Synonym Protein Names
Prostate transmembrane protein androgen induced 1; Solid tumor-associated 1 protein; Transmembrane prostate androgen-induced protein
Protein Family
Protein
UniProt Gene Name
PMEPA1
UniProt Synonym Gene Names
STAG1; TMEPAI
UniProt Entry Name
PMEPA_HUMAN
NCBI Protein Information
protein TMEPAI

NCBI Summary for PMEPA1

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for PMEPA1

TMEPAI: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Belongs to the PMEPA1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.31-q13.33

Cellular Component: early endosome membrane; endosome membrane; Golgi membrane; intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function: protein binding; WW domain binding

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway
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Research Articles on PMEPA1

1. Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PMEPA1 cdna clone

 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram

Diseases associated with PMEPA1 cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with PMEPA1 and Neoplasms
 Prostatic Neoplasms Antibodies  >16 publications with PMEPA1 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >5 publications with PMEPA1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >5 publications with PMEPA1 and Neoplasms, Experimental
 Chromosome Aberrations Antibodies  >2 publications with PMEPA1 and Chromosome Aberrations
 Breast Neoplasms Antibodies  >2 publications with PMEPA1 and Breast Neoplasms
 Hyperplasia Antibodies  >2 publications with PMEPA1 and Hyperplasia
 Fibrosis Antibodies  >1 publications with PMEPA1 and Fibrosis
 Liver Diseases Antibodies  >1 publications with PMEPA1 and Liver Diseases
 Ovarian Neoplasms Antibodies  >1 publications with PMEPA1 and Ovarian Neoplasms

Organs/Tissues associated with PMEPA1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >20 publications with PMEPA1 and Prostate
 Mammary Gland Antibodies  >2 publications with PMEPA1 and Mammary Gland
 Blood Antibodies  >2 publications with PMEPA1 and Blood
 Stomach Antibodies  >2 publications with PMEPA1 and Stomach
 Intestine Antibodies  >2 publications with PMEPA1 and Intestine
 Connective Tissue Antibodies  >1 publications with PMEPA1 and Connective Tissue
 Lung Antibodies  >1 publications with PMEPA1 and Lung
 Liver Antibodies  >1 publications with PMEPA1 and Liver
 Brain Antibodies  >1 publications with PMEPA1 and Brain
 Vascular Antibodies  >1 publications with PMEPA1 and Vascular
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