Human POLD1 cDNA Clone Expression Plasmid – Cat# MBS1273021

POLD1 cDNA Clone – Polymerase (DNA Directed), Delta 1, Catalytic Subunit 125kDa (Human)

Name: POLD1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273021
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273021

MBS1273021 is a cDNA clone targeting POLD1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

POLD1, cDNA Clone

Full Product Name

POLD1 cDNA Clone

Product Gene Name

POLD1 cdna clone

Sequence

atggatggca agcggcggcc aggcccaggg cccggggtgc ccccaaagcg ggcccgtggg ggcctctggg atgatgatga tgcacctcgg ccatcccaat tcgaggagga cctggcactg atggaggaga tggaggcaga acacaggctg caggagcagg aggaggagga gctgcagtca gtcctggagg gggttgcaga cgggcaggtc ccaccatcag ccatagatcc tcgctggctt cggcccacac caccagcgct ggacccccag acagagcccc tcatcttcca acagttggag attgaccatt atgtgggccc agcacagcct gtgcctgggg ggcccccacc atcccacggc tccgtgcctg tgctccgcgc cttcggggtc accgatgagg ggttctctgt ctgctgccac atccacggct tcgctcccta cttctacacc ccagcgcccc ctggtttcgg gcccgagcac atgggtgacc tgcaacggga gctgaacttg gccatcagcc gggacagtcg cggggggagg gagctgactg ggccggccgt gctggctgtg gaactgtgct cccgagagag catgtttggg taccacgggc acggcccctc cccgttcctg cgcatcaccg tggcgctgcc gcgcctcgtg gccccggccc gccgtctcct ggaacagggc atccgtgtgg caggcctggg cacgcccagc ttcgcgccct acgaggccaa cgtcgacttt gagatccggt tcatggtgga cacggacatc gtcggctgca actggctgga gctcccagct gggaaatacg ccctgaggct gaaggagaag gctacgcagt gccagctgga ggcggacgtg ctgtggtctg acgtggtcag tcacccaccg gaagggccat ggcagcgcat tgcgcccttg cgcgtgctca gcttcgatat cgagtgcgcc ggccgcaaag gcatcttccc tgagcctgag cgggaccctg tcatccagat ctgctcgctg ggcctgcgct ggggggagcc ggagcccttc ctacgcctgg cgctcaccct gcggccctgt gcccccatcc tgggtgccaa ggtgcagagc tacgagaagg aggaggacct gctgcaggcc tggtccacct tcatccgtat catggacccc gacgtgatca ccggttacaa catccagaac ttcgaccttc cgtacctcat ctctcgggcc cagaccctca aggtacaaac attccctttc ctgggccgtg tggccggcct ttgctccaac atccgggact cttcattcca gtccaagcag acgggccggc gggacaccaa ggttgtcagc atggtgggcc gcgtgcagat ggacatgctg caggtgctgc tgcgggagta caagctccgc tcctacacgc tcaatgccgt gagcttccac ttcctgggcg agcagaagga ggacgtgcag cacagcatca tcaccgacct gcagaatggg aacgaccaga cccgccgccg cctggctgtg tactgcctga aggatgccta cctgccactg cggctgctgg agcggctcat ggtgctggtg aacgccgtgg agatggcgag ggtcactggc gtgcccctca gctacctgct cagtcgtggc cagcaggtca aggtcgtatc ccagctgttg cggcaggcca tgcacgaggg gctgctgatg cccgtggtga agtcagaggg cggcgaggac tacacgggag ccactgtcat cgagcccctc aaagggtact acgacgtccc catcgccacc ctggacttct cctcgctgta cccgtccatc atgatggccc acaacctgtg ttacaccacg ctccttcggc ccgggactgc acagaaactg ggcctgactg aggatcagtt catcaggacc cccaccgggg acgagtttgt gaagacctca gtgcggaagg ggctgctgcc ccagatcctg gagaacctgc tcagtgcccg gaagagggcc aaggccgagc tggccaagga gacagacccc ctccggcgcc aggtcctgga tggacggcag ctggcgctga aggtgagcgc caactccgta tacggcttca ctggcgccca ggtgggcaag ttgccgtgcc tggagatctc acagagcgtc acggggttcg gacgtcagat gatcgagaaa accaagcagc tggtggagtc taagtacaca gtggagaatg gctacagcac cagtgccaag gtggtgtatg gtgacactga ctccgtcatg tgccgattcg gcgtgtcctc ggtggctgag gcgatggccc tggggcggga ggccgcggac tgggtgtcag gtcacttccc gtcgcccatc cggctggagt ttgagaaggt ctacttccca tacctgctta tcagcaagaa gcgctacgcg ggcctgctct tctcctcccg gcccgacgcc cacgaccgca tggactgcaa gggcctggag gccgtgcgca gggacaactg ccccctcgtg gccaacctgg tcactgcctc actgcgccgc ctgctcatcg accgagaccc tgagggcgcg gtggctcacg cacaggacgt catctcggac ctgctgtgca accgcatcga tatctcccag ctggtcatca ccaaggagct gacccgcgcg gcctccgact atgccggcaa gcaggcccac gtggagctgg ccgagaggat gaggaagcgg gaccccggga gtgcgcccag cctgggcgac cgcgtcccct acgtgatcat cagtgccgcc aagggtgtgg ccgcctacat gaagtcggag gacccgctgt tcgtgctgga gcacagcctg cccattgaca cgcagtacta cctggagcag cagctggcca agcccctcct gcgcatcttc gagcccatcc tgggcgaggg ccgtgccgag gctgtgctac tgcgggggga ccacacgcgc tgcaagacgg tgctcacggg caaggtgggc ggcctcctgg ccttcgccaa acgccgcaac tgctgcattg gctgccgcac agtgctcagc caccagggag ccgtgtgtga gttctgccag ccccgggagt ctgagctgta tcagaaggag gtatcccatc tgaatgccct ggaggagcgc ttctcgcgcc tctggacgca gtgccagcgc tgccagggca gcctgcacga ggacgtcatc tgcaccagcc gggactgccc catcttctac atgcgcaaga aggtgcggaa ggacctggaa gaccaggagc agctcctgcg gcgcttcgga ccccctggac ctgaggcctg gtga

Molecular Weight

123,631 Da

OMIM

174761

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of POLD1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for POLD1. It may not necessarily be applicable to this product.

NCBI GI #

14250669

NCBI GeneID

5424

NCBI Accession #

BC008800

UniProt Secondary Accession #

Q8NER3; Q96H98

UniProt Related Accession #

P28340

NCBI Official Full Name

Homo sapiens polymerase (DNA directed), delta 1, catalytic subunit 125kDa, mRNA

NCBI Official Synonym Full Names

DNA polymerase delta 1, catalytic subunit

NCBI Official Symbol

POLD1

NCBI Official Synonym Symbols

CDC2; MDPL; POLD; CRCS10

UniProt Protein Name

DNA polymerase delta catalytic subunit

UniProt Synonym Protein Names

DNA polymerase subunit delta p125

Protein Family

DNA polymerase

UniProt Gene Name

POLD1

UniProt Synonym Gene Names

POLD

UniProt Entry Name

DPOD1_HUMAN

NCBI Protein Information

DNA polymerase delta catalytic subunit

NCBI Summary for POLD1

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

UniProt Comments for POLD1

POLD1: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. Belongs to the DNA polymerase type-B family.

Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 2.7.7.7; Hydrolase; Transferase; DNA replication; DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; delta DNA polymerase complex; membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleotide-excision repair complex; nucleus

Molecular Function: 3'-5'-exodeoxyribonuclease activity; chromatin binding; damaged DNA binding; DNA binding; DNA-directed DNA polymerase activity; protein binding

Biological Process: base-excision repair, gap-filling; bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA repair; DNA replication; DNA replication proofreading; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; fatty acid homeostasis; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair

Disease: Colorectal Cancer, Susceptibility To, 10; Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome

Research Articles on POLD1

1. Mutations in POLE and POLD1 in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with POLD1 cdna clone

Products by Pathway	Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Cytosolic Iron-sulfur Cluster Assembly Pathway antibodies	Cytosolic Iron-sulfur Cluster Assembly Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with POLD1 cdna clone

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>5 publications with POLD1 and Breast Neoplasms
Drug Toxicity Antibodies	>1 publications with POLD1 and Drug Toxicity
Urinary Bladder Neoplasms Antibodies	>1 publications with POLD1 and Urinary Bladder Neoplasms
Skin Neoplasms Antibodies	>1 publications with POLD1 and Skin Neoplasms
Heart Diseases Antibodies	>1 publications with POLD1 and Heart Diseases
Liver Neoplasms Antibodies	>1 publications with POLD1 and Liver Neoplasms