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POLL cDNA Clone – Polymerase (DNA Directed), Lambda (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269651

MBS1269651 is a cDNA clone targeting POLL. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
POLL, cDNA Clone
Full Product Name
POLL cDNA Clone
Product Gene Name
POLL cdna clone
Sequence
atgcatcatc aaaagtactt gcaaagattc ctaggaggga agagggagaa gaagcagaag gaggcctgca gtatccctgg gattgggaag cggatggctg agaaaatcat agagatcctg gagagcgggc atttgcggaa gctggaccat atcagtgaga gcgtgcctgt cttggagctc ttctccaaca tctggggagc tgggaccaag actgcccaga tgtggtacca acagggcttc cgaagtctgg aagacatccg cagccaggcc tccctgacaa cccagcaggc catcggcctg aagcattaca gtgacttcct ggaacgtatg cccagggagg aggctacaga gattgagcag acagtccaga aagcagccca ggcctttaac tctgggctgc tgtgtgtggc atgtggttca taccgacggg gaaaggcgac ctgtggtgat gtcgacgtgc tcatcactca cccagatggc cggtcccacc ggggtatctt cagccgcctc cttgacagtc ttcggcagga agggttcctc acagatgact tggtgagcca agaggagaat ggtcagcaac agaagtactt gggggtgtgc cggctcccag ggccagggcg gcggcaccgg cgcctggaca tcatcgtggt gccctatagc gagtttgcct gtgccctgct ctacttcacc ggctctgcac acttcaaccg ctccatgcga gccctggcca aaaccaaggg catgagtctg tcagaacatg ccctcagcac tgctgtggtc cggaacaccc atggctgcaa ggtggggcct ggccgagtgc tgcccactcc cactgagaag gatgtcttca ggctcttagg cctcccctac cgagaacctg ctgagcggga ctggtga
Molecular Weight
33,839 Da
OMIM
606343
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of POLL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for POLL. It may not necessarily be applicable to this product.

NCBI GI #
13097671
NCBI GeneID
27343
NCBI Accession #
BC003548
UniProt Secondary Accession #
Q5JQP5; Q6NUM2; Q9BTN8; Q9HA10; Q9HB35; D3DR76
UniProt Related Accession #
Q9UGP5
NCBI Official Full Name
Homo sapiens polymerase (DNA directed), lambda, mRNA
NCBI Official Synonym Full Names
DNA polymerase lambda
NCBI Official Symbol
POLL
NCBI Official Synonym Symbols
BETAN; POLKAPPA
UniProt Protein Name
DNA polymerase lambda
UniProt Synonym Protein Names
DNA polymerase beta-2; Pol beta2; DNA polymerase kappa
Protein Family
DNA polymerase
UniProt Gene Name
POLL
UniProt Synonym Gene Names
Pol Lambda; Pol beta2
UniProt Entry Name
DPOLL_HUMAN
NCBI Protein Information
DNA polymerase lambda

NCBI Summary for POLL

This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
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UniProt Comments for POLL

POLL: Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Belongs to the DNA polymerase type-X family.

Protein type: Lyase; Transferase; DNA repair, damage; EC 2.7.7.7

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: nucleoplasm

Molecular Function: DNA-directed DNA polymerase activity

Biological Process: double-strand break repair via nonhomologous end joining; nucleotide-excision repair
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Research Articles on POLL

1. Pol beta, to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with POLL cdna clone

 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram

Diseases associated with POLL cdna clone

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >341 publications with POLL and Inflammation
 Nervous System Diseases Antibodies  >200 publications with POLL and Nervous System Diseases
 Neoplasms Antibodies  >180 publications with POLL and Neoplasms
 Necrosis Antibodies  >165 publications with POLL and Necrosis
 Skin Diseases Antibodies  >66 publications with POLL and Skin Diseases
 Liver Diseases Antibodies  >59 publications with POLL and Liver Diseases
 Heart Diseases Antibodies  >53 publications with POLL and Heart Diseases
 Uterine Neoplasms Antibodies  >37 publications with POLL and Uterine Neoplasms
 Uterine Cervical Neoplasms Antibodies  >32 publications with POLL and Uterine Cervical Neoplasms
 Breast Neoplasms Antibodies  >32 publications with POLL and Breast Neoplasms

Organs/Tissues associated with POLL cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >534 publications with POLL and Blood
 Lung Antibodies  >220 publications with POLL and Lung
 Liver Antibodies  >129 publications with POLL and Liver
 Brain Antibodies  >120 publications with POLL and Brain
 Bone Antibodies  >92 publications with POLL and Bone
 Vascular Antibodies  >84 publications with POLL and Vascular
 Heart Antibodies  >69 publications with POLL and Heart
 Kidney Antibodies  >63 publications with POLL and Kidney
 Muscle Antibodies  >62 publications with POLL and Muscle
 Skin Antibodies  >39 publications with POLL and Skin
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