Human PRC1 cDNA Clone Expression Plasmid – Cat# MBS1273608

PRC1 cDNA Clone – Protein Regulator of Cytokinesis 1 (Human)

Name: PRC1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273608
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273608

MBS1273608 is a cDNA clone targeting PRC1. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRC1, cDNA Clone

Full Product Name

PRC1 cDNA Clone

Product Gene Name

PRC1 cdna clone

Sequence

atgaggagaa gtgaggtgct ggcggaggag tccatagtat gtctgcagaa agccctaaat caccttcggg aaatatggga gctaattggg attccagagg accagcggtt acaaagaact gaggtggtaa agaagcatat caaggaactc ctggatatga tgattgctga agaggaaagc ctgaaggaaa gactcatcaa aagcatatcc gtctgtcaga aagagctgaa cactctgtgc agcgagttac atgttgagcc atttcaggaa gaaggagaga caaccatctt gcaactagaa aaagatttgc gcacccaagt ggaattgatg cgaaaacaga aaaaggagag aaaacaggaa ctgaagctac ttcaagagca agatcaagaa ctgtgcgaaa ttctttgtat gccccactat gatattgaca gtgcctcagt gcccagctta gaagaactga accagttcag gcaacatgtg acaactttga gggaaacaaa ggcttctagg cgtgaggagt ttgtcagtat aaagagacag atcatactgt gtatggaaga attagaccac accccagaca caagctttga aagagatgtg gtgtgtgaag acgaagatgc cttttgtttg tctttggaga atattgcaac actacaaaag ttgctacggc agctggaaat gcagaaatca caaaatgaag cagtgtgtga ggggctgcgt actcaaatcc gagagctctg ggacaggttg caaatacctg aagaagaaag agaagctgtg gccaccatta tgtctgggtc aaaggccaag gtccggaaag cgctgcaatt agaagtggat cggttggaag aactgaaaat gcaaaacatg aagaaagtga ttgaggcaat tcgagtggag ctggttcagt actgggacca gtgcttttat agccaggagc agagacaagc ttttgcccct ttctgtgctg aggactacac agaaagtctg ctccagctcc acgatgctga gattgtgcgg ttaaaaaact actatgaagt tcacaaggaa ctctttgaag gtgtccagaa gtgggaagaa acctggaggc ttttcttaga gtttgagaga aaagcttcag atccaaatcg atttacaaac cgaggaggaa atcttctaaa agaagaaaaa caacgagcca agctccagaa attcatggag tatgtggcag aacaatggga gatgcatcga ttggagaaag agagagccaa gcaggaaaga caactgaaga acaaaaaaca gacagagaca gagatgctgt atggcagcgc tcctcgaaca cctagcaagc ggcgaggact ggctcccaat acaccgggca aagcacgtaa gctgaacact accaccatgt ccaatgctac ggccaatagt agcattcggc ctatctttgg agggacagtc taccactccc ccgtgtctcg acttcctcct tctggcagca agccagtcgc tgcttccacc tgttcaggga agaaaacacc ccgtactggc aggcatggag ccaacaagga gaacctggag ctcaacggca gcatcctgag tggtgggtac cctggctcgg cccccctcca gcgcaacttc agcattaatt ctgttgccag cacctattct gagtttgcgc gagaactttc aaaggcttcc aaatctgatg ctacttctgg aatcctcaat tcaaccaaca tccagtcctg a

Molecular Weight

70,191 Da

OMIM

603484

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PRC1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRC1. It may not necessarily be applicable to this product.

NCBI GI #

33869425

NCBI GeneID

9055

NCBI Accession #

BC005140

UniProt Secondary Accession #

Q9BSB6; A6NC44; B4DLR1; H9KV59

UniProt Related Accession #

O43663

NCBI Official Full Name

Homo sapiens protein regulator of cytokinesis 1, mRNA

NCBI Official Synonym Full Names

protein regulator of cytokinesis 1

NCBI Official Symbol

PRC1

NCBI Official Synonym Symbols

ASE1

UniProt Protein Name

Protein regulator of cytokinesis 1

Protein Family

Protein regulator of cytokinesis

UniProt Gene Name

PRC1

UniProt Entry Name

PRC1_HUMAN

NCBI Protein Information

protein regulator of cytokinesis 1

NCBI Summary for PRC1

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UniProt Comments for PRC1

PRC1: translocates to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Acts as a microtubule-binding and bundling protein both in vivo and vitro. Interacts with the C-terminal Rho-GAP domain and the basic region of MgcRacGAP. The interaction with MgcRacGAP inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Cell cycle regulation; Microtubule-binding

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: cytoplasm; cytosol; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; plasma membrane; spindle; spindle microtubule

Molecular Function: kinesin binding; protein binding; protein kinase binding

Biological Process: cytokinesis; mitotic spindle elongation; positive regulation of cell proliferation

Research Articles on PRC1

1. PP2A-B55 dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL) kinase and its substrate ENSA, explaining the timing of PRC1 activation in anaphase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PRC1 cdna clone

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>10 publications with PRC1 and Adenocarcinoma
Breast Neoplasms Antibodies	>9 publications with PRC1 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>6 publications with PRC1 and Cell Transformation, Neoplastic
Gastrointestinal Diseases Antibodies	>4 publications with PRC1 and Gastrointestinal Diseases
Drug Toxicity Antibodies	>2 publications with PRC1 and Drug Toxicity
Carcinoma, Hepatocellular Antibodies	>2 publications with PRC1 and Carcinoma, Hepatocellular
Neoplasm Metastasis Antibodies	>2 publications with PRC1 and Neoplasm Metastasis
Liver Diseases Antibodies	>1 publications with PRC1 and Liver Diseases
Urinary Bladder Neoplasms Antibodies	>1 publications with PRC1 and Urinary Bladder Neoplasms
Liver Neoplasms Antibodies	>1 publications with PRC1 and Liver Neoplasms

Organs/Tissues associated with PRC1 cdna clone

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>6 publications with PRC1 and Embryonic Tissue
Lung Antibodies	>5 publications with PRC1 and Lung
Skin Antibodies	>5 publications with PRC1 and Skin
Prostate Antibodies	>4 publications with PRC1 and Prostate
Heart Antibodies	>2 publications with PRC1 and Heart
Bladder Antibodies	>1 publications with PRC1 and Bladder
Eye Antibodies	>1 publications with PRC1 and Eye