PRDX3 cDNA Clone – Peroxiredoxin 3 (Human)

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family.

Protein type: EC 1.11.1.15; Apoptosis; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q25-q26

Cellular Component: cytoplasm; cytosol; early endosome; IkappaB kinase complex; mitochondrial matrix; mitochondrion

Molecular Function: caspase inhibitor activity; kinase binding; protein binding; protein C-terminus binding; protein kinase binding; thioredoxin peroxidase activity

Biological Process: activation of NF-kappaB transcription factor; hydrogen peroxide catabolic process; mitochondrion organization and biogenesis; myeloid cell differentiation; negative regulation of apoptosis; negative regulation of kinase activity; peptidyl-cysteine oxidation; positive regulation of cell proliferation; regulation of mitochondrial membrane potential; response to hydrogen peroxide; response to lipopolysaccharide; response to oxidative stress; response to reactive oxygen species