• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PRKCA cDNA Clone – Protein Kinase C, Alpha (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271168

MBS1271168 is a cDNA clone targeting PRKCA. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRKCA, cDNA Clone
Full Product Name
PRKCA cDNA Clone
Product Gene Name
PRKCA cdna clone
Sequence
ATGGCTGACG TTTTCCCGGG CAACGACTCC ACGGCGTCTC AGGACGTGGC CAACCGCTTC GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TCCACAAGAG GTGCCATGAA TTTGTTACTT TTTCTTGTCC GGGTGCGGAT AAGGGACCCG ACACTGATGA CCCCAGGAGC AAGCACAAGT TCAAAATCCA CACTTACGGA AGCCCCACCT TCTGCGATCA CTGTGGGTCA CTGCTCTATG GACTTATCCA TCAAGGGATG AAATGTGACA CCTGCGATAT GAACGTTCAC AAGCAATGCG TCATCAATGT CCCCAGCCTC TGCGGAATGG ATCACACTGA GAAGAGGGGG CGGATTTACC TAAAGGCTGA GGTTGCTGAT GAAAAGCTCC ATGTCACAGT ACGAGATGCA AAAAATCTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT ATTCCTGATC CCAAGAATGA AAGCAAGCAA AAAACCAAAA CCATCCGCTC CACACTAAAT CCGCAGTGGA ATGAGTCCTT TACATTCAAA TTGAAACCTT CAGACAAAGA CCGACGACTG TCTGTAGAAA TCTGGGACTG GGATCGAACA ACAAGGAATG ACTTCATGGG ATCCCTTTCC TTTGGAGTTT CGGAGCTGAT GAAGATGCCG GCCAGTGGAT GGTACAAGTT GCTTAACCAA GAAGAAGGTG AGTACTACAA CGTACCCATT CCGGAAGGGG ACGAGGAAGG AAACATGGAA CTCAGGCAGA AATTCGAGAA AGCCAAACTT GGCCCTGCTG GCAACAAAGT CATCAGTCCC TCTGAAGACA GGAAACAACC TTCCAACAAC CTTGACCGAG TGAAACTCAC GGACTTCAAT TTCCTCATGG TGTTGGGAAA GGGGAGTTTT GGAAAGGTGA TGCTTGCCGA CAGGAAGGGC ACAGAAGAAC TGTATGCAAT CAAAATCCTG AAGAAGGATG TGGTGATTCA GGATGATGAC GTGGAGTGCA CCATGGTAGA AAAGCGAGTC TTGGCCCTGC TTGACAAACC CCCGTTCTTG ACGCAGCTGC ACTCCTGCTT CCAGACAGTG GATCGGCTGT ACTTCGTCAT GGAATATGTC AACGGTGGGG ACCTCATGTA CCACATTCAG CAAGTAGGAA AATTTAAGGA ACCACAAGCA GTATTCTATG CGGCAGAGAT TTCCATCGGA TTGTTCTTTC TTCATAAAAG AGGAATCATT TATAGGGATC TGAAGTTAGA TAACGTCATG TTGGATTCAG AAGGACATAT CAAAATTGCT GACTTTGGGA TGTGCAAGGA ACACATGATG GATGGAGTCA CGACCAGGAC CTTCTGTGGG ACTCCAGATT ATATCGCCCC AGAGATAATC GCTTATCAGC CGTATGGAAA ATCTGTGGAC TGGTGGGCCT ATGGCGTCCT GTTGTATGAA ATGCTTGCCG GGCAGCCTCC ATTTGATGGT GAAGATGAAG ACGAGCTATT TCAGTCTATC ATGGAGCACA ACGTTTCCTA TCCAAAATCC TTGTCCAAGG AGGCTGTTTC TATCTGCAAA GGACTGATGA CCAAACACCC AGCCAAGCGG CTGGGCTGTG GGCCTGAGGG GGAGAGGGAC GTGAGAGAGC ATGCCTTCTT CCGGAGGATC GACTGGGAAA AACTGGAGAA CAGGGAGATC CAGCCACCAT TCAAGCCCAA AGTGTGTGGC AAAGGAGCAG AGAACTTTGA CAAGTTCTTC ACACGAGGAC AGCCCGTCTT AACACCACCT GATCAGCTGG TTATTGCTAA CATAGACCAG TCTGATTTTG AAGGGTTCTC GTATGTCAAC CCCCAGTTTG TGCACCCCAT CTTACAGAGT GCAGTATGA
Molecular Weight
76,750 Da
OMIM
176960
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PRKCA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKCA. It may not necessarily be applicable to this product.

NCBI GI #
80475926
NCBI GeneID
5578
NCBI Accession #
BC109273
UniProt Secondary Accession #
Q15137; Q32M72; Q96RE4; B5BU22
UniProt Related Accession #
P17252
NCBI Official Full Name
Homo sapiens protein kinase C, alpha, mRNA
NCBI Official Synonym Full Names
protein kinase C alpha
NCBI Official Symbol
PRKCA
NCBI Official Synonym Symbols
AAG6; PKCA; PRKACA; PKC-alpha
UniProt Protein Name
Protein kinase C alpha type
Protein Family
Protein kinase
UniProt Gene Name
PRKCA
UniProt Synonym Gene Names
PKCA; PRKACA; PKC-A; PKC-alpha
UniProt Entry Name
KPCA_HUMAN
NCBI Protein Information
protein kinase C alpha type

NCBI Summary for PRKCA

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for PRKCA

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: Kinase, protein; Protein kinase, AGC; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 17q22-q23.2

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; plasma membrane

Molecular Function: calcium-dependent protein kinase C activity; enzyme binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: adenylate cyclase activation; mitotic nuclear envelope disassembly; negative regulation of adenylate cyclase activity; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of insulin secretion; regulation of mRNA stability
Show more

Research Articles on PRKCA

1. we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PRKCA cdna clone

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram

Diseases associated with PRKCA cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >610 publications with PRKCA and Neoplasms
 Cardiovascular Diseases Antibodies  >147 publications with PRKCA and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >113 publications with PRKCA and Nervous System Diseases
 Inflammation Antibodies  >104 publications with PRKCA and Inflammation
 Brain Diseases Antibodies  >99 publications with PRKCA and Brain Diseases
 Drug Toxicity Antibodies  >96 publications with PRKCA and Drug Toxicity
 Necrosis Antibodies  >81 publications with PRKCA and Necrosis
 Heart Diseases Antibodies  >78 publications with PRKCA and Heart Diseases
 Neoplasms, Experimental Antibodies  >73 publications with PRKCA and Neoplasms, Experimental
 Hypertension Antibodies  >65 publications with PRKCA and Hypertension

Organs/Tissues associated with PRKCA cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >374 publications with PRKCA and Muscle
 Blood Antibodies  >362 publications with PRKCA and Blood
 Brain Antibodies  >312 publications with PRKCA and Brain
 Vascular Antibodies  >305 publications with PRKCA and Vascular
 Kidney Antibodies  >160 publications with PRKCA and Kidney
 Liver Antibodies  >138 publications with PRKCA and Liver
 Eye Antibodies  >120 publications with PRKCA and Eye
 Nerve Antibodies  >100 publications with PRKCA and Nerve
 Skin Antibodies  >74 publications with PRKCA and Skin
 Intestine Antibodies  >63 publications with PRKCA and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000