Human PROS1 cDNA Clone Expression Plasmid – Cat# MBS1265768

PROS1 cDNA Clone – Protein S (Alpha) (Human)

Name: PROS1 cDNA Clone; Protein S (Alpha); Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265768
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265768

MBS1265768 is a cDNA clone targeting PROS1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PROS1, cDNA Clone

Full Product Name

PROS1 cDNA Clone

Product Gene Name

PROS1 cdna clone

Sequence

atgagggtcc tgggtgggcg ctgcggggcg ctgctggcgt gtctcctcct agtgcttccc gtctcagagg caaacttttt gtcaaagcaa caggcttcac aagtcctggt taggaagcgt cgtgcaaatt ctttacttga agaaaccaaa cagggtaatc ttgaaagaga atgcatcgaa gaactgtgca ataaagaaga agccagggag gtctttgaaa atgacccgga aacggattat ttttatccaa aatacttagt ttgtcttcgc tcttttcaaa ctgggttatt cactgctgca cgtcagtcaa ctaatgctta tcctgaccta agaagctgtg tcaatgccat tccagaccag tgtagtcctc tgccatgcaa tgaagatgga tatatgagct gcaaagatgg aaaagcttct tttacttgca cttgtaaacc aggttggcaa ggagaaaagt gtgaatttga cataaatgaa tgcaaagatc cctcaaatat aaatggaggt tgcagtcaaa tttgtgataa tacacctgga agttaccact gttcctgtaa aaatggtttt gttatgcttt caaataagaa agattgtaaa gatgtggatg aatgctcttt gaagccaagc atttgtggca cagctgtgtg caagaacatc ccaggagatt ttgaatgtga atgccccgaa ggctacagat ataatctcaa atcaaagtct tgtgaagata tagatgaatg ctctgagaac atgtgtgctc agctttgtgt caattaccct ggaggttaca cttgctattg tgatgggaag aaaggattca aacttgccca agatcagaag agttgtgagg ttgtttcagt gtgccttccc ttgaaccttg acacaaagta tgaattactt tacttggcgg agcagtttgc aggggttgtt ttatatttaa aatttcgttt gccagaaatc agcagatttt cagcagaatt tgatttccgg acatatgatt cagaaggcgt gatactgtac gcagaatcta tcgatcactc agcgtggctc ctgattgcac ttcgtggtgg aaagattgaa gttcagctta agaatgaaca tacatccaaa atcacaactg gaggtgatgt tattaataat ggtctatgga atatggtgtc tgtggaagaa ttagaacata gtattagcat taaaatagct aaagaagctg tgatggatat aaataaacct ggaccccttt ttaagccgga aaatggattg ctggaaacca aagtatactt tgcaggattc cctcggaaag tggaaagtga actcattaaa ccgattaacc ctcgtctaga tggatgtata cgaagctgga atttgatgaa gcaaggagct tctggaataa aggaaattat tcaagaaaaa caaaataagc attgcctggt tactgtggag aagggctcct actatcctgg ttctggaatt gctcaatttc acatagatta taataatgta tccagtgctg agggttggca tgtaaatgtg accttgaata ttcgtccatc cacgggcact ggtgttatgc ttgccttggt ttctggtaac aacacagtgc cctttgctgt gtccttggtg gactccacct ctgaaaaatc acaggatatt ctgttatctg ttgaaaatac tgtaatatat cggatacagg ccctaagtct atgttccgat caacaatctc atctggaatt tagagtcaac agaaacaatc tggagttgtc gacaccactt aaaatagaaa ccatctccca tgaagacctt caaagacaac ttgccgtctt ggacaaagca atgaaagcaa aagtggccac atacctgggt ggccttccag atgttccatt cagtgccaca ccagtgaatg ccttttataa tggctgcatg gaagtgaata ttaatggtgt acagttggat ctggatgaag ccatttctaa acataatgat attagagctc actcatgtcc atcagtttgg aaaaagacaa agaattctta a

Molecular Weight

75,123 Da

OMIM

176880

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PROS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PROS1. It may not necessarily be applicable to this product.

NCBI GI #

16041821

NCBI GeneID

5627

NCBI Accession #

BC015801

UniProt Secondary Accession #

Q15518; Q7Z715; Q9UCZ8; A8KAC9; D3DN28

UniProt Related Accession #

P07225

NCBI Official Full Name

Homo sapiens protein S (alpha), mRNA

NCBI Official Synonym Full Names

protein S (alpha)

NCBI Official Symbol

PROS1

NCBI Official Synonym Symbols

PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6

UniProt Protein Name

Vitamin K-dependent protein S

Protein Family

Proline--tRNA ligase

UniProt Gene Name

PROS1

UniProt Synonym Gene Names

PROS

UniProt Entry Name

PROS_HUMAN

NCBI Protein Information

vitamin K-dependent protein S

NCBI Summary for PROS1

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

UniProt Comments for PROS1

PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi lumen; Golgi membrane; plasma membrane

Molecular Function: endopeptidase inhibitor activity

Biological Process: blood coagulation; ER to Golgi vesicle-mediated transport; leukocyte migration; peptidyl-glutamic acid carboxylation; platelet degranulation; regulation of complement activation; signal peptide processing

Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Dominant; Thrombophilia Due To Protein S Deficiency, Autosomal Recessive

Research Articles on PROS1

1. The ELISA system using the PS K196E mutation-specific antibody is a useful tool for the rapid identification of PS K196E carriers, who are at a higher risk for venous thromboembolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PROS1 cdna clone

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Common Pathway antibodies	Common Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Gamma-carboxylation Of Protein Precursors Pathway antibodies	Gamma-carboxylation Of Protein Precursors Pathway Diagram
Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies	Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with PROS1 cdna clone

Disease Name	Pubmed Publications
Blood Coagulation Disorders Antibodies	>62 publications with PROS1 and Blood Coagulation Disorders
Thrombosis Antibodies	>53 publications with PROS1 and Thrombosis
Cardiovascular Diseases Antibodies	>37 publications with PROS1 and Cardiovascular Diseases
Vascular Diseases Antibodies	>37 publications with PROS1 and Vascular Diseases
Venous Thrombosis Antibodies	>29 publications with PROS1 and Venous Thrombosis
Thromboembolism Antibodies	>11 publications with PROS1 and Thromboembolism
Venous Thromboembolism Antibodies	>9 publications with PROS1 and Venous Thromboembolism
Neoplasms Antibodies	>7 publications with PROS1 and Neoplasms
THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT Antibodies	>4 publications with PROS1 and THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT
Inflammation Antibodies	>3 publications with PROS1 and Inflammation

Organs/Tissues associated with PROS1 cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>8 publications with PROS1 and Vascular
Liver Antibodies	>6 publications with PROS1 and Liver
Thyroid Antibodies	>2 publications with PROS1 and Thyroid
Kidney Antibodies	>2 publications with PROS1 and Kidney
Brain Antibodies	>2 publications with PROS1 and Brain
Heart Antibodies	>1 publications with PROS1 and Heart
Lung Antibodies	>1 publications with PROS1 and Lung
Muscle Antibodies	>1 publications with PROS1 and Muscle
Intestine Antibodies	>1 publications with PROS1 and Intestine