Human PTPRN cDNA Clone Expression Plasmid – Cat# MBS1277021

PTPRN cDNA Clone – Protein Tyrosine Phosphatase, Receptor Type, N (Human)

Name: PTPRN cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277021
Price: 680 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277021

MBS1277021 is a cDNA clone targeting PTPRN. More details

$680 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTPRN, cDNA Clone

Full Product Name

PTPRN cDNA Clone

Product Gene Name

PTPRN cdna clone

Sequence

atggaggggc cggtggaggg cagagacaca gcagagcttc cagcccgcac atcccccatg cctggacacc ccactgccag ccctacctcc agtgaagtcc agcaggtgcc aagccctgtc tcctctgagc ctcccaaagc tgccagaccc cctgtgacac ctgtcctgct agagaagaaa agcccactgg gccagagcca gcccacggtg gcaggacagc cctcagcccg cccagcagca gaggaatatg gctacatcgt cactgatcag aagcccctga gcctggctgc aggagtgaag ctgctggaga tcctggctga gcatgtgcac atgtcctcag gcagcttcat caacatcagt gtggtgggac cagccctcac cttccgcatc cggcacaatg agcagaacct gtctttggct gatgtgaccc aacaagcagg gctggtgaag tctgaactgg aagcacagac agggctccaa atcttgcaga caggagtggg acagagggag gaggcagctg cagtccttcc ccaaactgcg cacagcacct cacccatgcg ctcagtgctg ctcactctgg tggccctggc aggtgtggct gggctgctgg tggctctggc tgtggctctg tgtgtgcggc agcatgcgcg gcagcaagac aaggagcgcc tggcagccct ggggcctgag ggggcccatg gtgacactac ctttgagtac caggacctgt gccgccagca catggccacg aagtccttgt tcaaccgggc agagggtcca ccggagcctt cacgggtgag cagtgtgtcc tcccagttca gcgacgcagc ccaggccagc cccagctccc acagcagcac cccgtcctgg tgcgaggagc cggcccaagc caacatggac atctccacgg gacacatgat tctggcatac atggaggatc acctgcggaa ccgggaccgc cttgccaagg agtggcaggc cctctgtgcc taccaagcag agccaaacac ctgtgccacc gcgcaggggg agggcaacat caaaaagaac cggcatcctg acttcctgcc ctatgaccat gcccgcataa aactgaaggt ggagagcagc ccttctcgga gcgattacat caacgccagc cccattattg agcatgaccc tcggatgcca gcctacatag ccacgcaggg cccgctgtcc cataccatcg cagacttctg gcagatggtg tgggagagcg gctgcaccgt catcgtcatg ctgaccccgc tggtggagga tggtgtcaag cagtgtgacc gctactggcc agatgagggt gcctccctct accacgtata tgaggtgaac ctggtgtcgg agcacatctg gtgcgaggac tttctggtgc ggagcttcta cctgaagaac gtgcagaccc aggagacgcg cacgctcacg cagttccact tcctcagctg gccggcagag ggcacaccgg cctccacgcg gcccctgctg gacttccgca ggaaggtgaa caagtgctac cggggccgct cctgccccat catcgtgcac tgcagtgatg gtgcggggag gaccggcacc tacatcctca tcgacatggt cctgaaccgc atggcaaaag gagtgaagga gattgacatc gctgccaccc tggagcatgt ccgtgaccag cggcctggcc ttgtccgctc taaggaccag tttgaatttg ccctgacagc cgtggcggag gaagtgaatg ccatcctcaa ggccctgccc cagtga

Molecular Weight

96,261 Da

OMIM

601773

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PTPRN cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.

NCBI GI #

39644799

NCBI GeneID

5798

NCBI Accession #

BC007713

UniProt Secondary Accession #

Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3

UniProt Related Accession #

Q16849

NCBI Official Full Name

Homo sapiens protein tyrosine phosphatase, receptor type, N, mRNA

NCBI Official Synonym Full Names

protein tyrosine phosphatase, receptor type N

NCBI Official Symbol

PTPRN

NCBI Official Synonym Symbols

IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

UniProt Protein Name

Receptor-type tyrosine-protein phosphatase-like N

UniProt Synonym Protein Names

Islet cell antigen 512

Protein Family

Receptor-type tyrosine-protein phosphatase

UniProt Gene Name

PTPRN

UniProt Synonym Gene Names

ICA3; ICA512; ICA 512

UniProt Entry Name

PTPRN_HUMAN

NCBI Protein Information

receptor-type tyrosine-protein phosphatase-like N

NCBI Summary for PTPRN

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

UniProt Comments for PTPRN

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor protein phosphatase, tyrosine; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: cell soma; endosome; Golgi apparatus; nerve terminal; plasma membrane; secretory granule; synapse; synaptic vesicle

Molecular Function: protein binding; protein tyrosine phosphatase activity; spectrin binding

Biological Process: insulin secretion; luteinization; response to reactive oxygen species

Research Articles on PTPRN

1. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PTPRN cdna clone

Products by Pathway	Pathway Diagram
Type I Diabetes Mellitus Pathway antibodies	Type I Diabetes Mellitus Pathway Diagram
Type I Diabetes Mellitus Pathway antibodies	Type I Diabetes Mellitus Pathway Diagram

Diseases associated with PTPRN cdna clone

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>189 publications with PTPRN and Autoimmune Diseases
Immune System Diseases Antibodies	>188 publications with PTPRN and Immune System Diseases
Neoplasms Antibodies	>14 publications with PTPRN and Neoplasms
Nervous System Diseases Antibodies	>9 publications with PTPRN and Nervous System Diseases
Disease Models, Animal Antibodies	>7 publications with PTPRN and Disease Models, Animal
Brain Diseases Antibodies	>4 publications with PTPRN and Brain Diseases
Kidney Diseases Antibodies	>3 publications with PTPRN and Kidney Diseases
Weight Loss Antibodies	>2 publications with PTPRN and Weight Loss
Inflammation Antibodies	>2 publications with PTPRN and Inflammation
Liver Diseases Antibodies	>2 publications with PTPRN and Liver Diseases

Organs/Tissues associated with PTPRN cdna clone

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>130 publications with PTPRN and Pancreas
Brain Antibodies	>29 publications with PTPRN and Brain
Nerve Antibodies	>6 publications with PTPRN and Nerve
Lung Antibodies	>6 publications with PTPRN and Lung
Kidney Antibodies	>4 publications with PTPRN and Kidney
Pituitary Gland Antibodies	>4 publications with PTPRN and Pituitary Gland
Muscle Antibodies	>3 publications with PTPRN and Muscle
Eye Antibodies	>3 publications with PTPRN and Eye
Embryonic Tissue Antibodies	>2 publications with PTPRN and Embryonic Tissue