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QKI cDNA Clone – Quaking Homolog, Kh Domain RNA Binding (Mouse) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272880

MBS1272880 is a cDNA clone targeting QKI. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
QKI, cDNA Clone
Full Product Name
QKI cDNA Clone
Product Gene Name
QKI cdna clone
Sequence
atggtcgggg aaatggaaac gaaggagaag ccgaagccca ccccagatta cctgatgcag ctgatgaacg acaagaagct catgagcagc ctgcccaact tctgcgggat cttcaaccac ctcgagcggc tgctggacga agaaattagc agagtacgga aagacatgta caatgacaca ttaaatggca gtacagagaa aaggagtgca gaattgcctg atgctgtggg acctattgtt cagttacaag agaaacttta tgtgcctgta aaagaatacc cagattttaa ttttgttggg agaatccttg gacctagagg acttacagcc aaacaacttg aagcagaaac cggatgtaaa atcatggtcc gaggcaaagg ctcaatgagg gataaaaaaa aggaggagca aaatagaggc aagcccaatt gggagcatct aaatgaagat ttacatgtac taatcactgt ggaagatgct cagaacagag cagaaatcaa attgaagaga gcagttgaag aagtgaagaa attattggta cctgcagcag aaggagaaga cagcctgaag aagatgcagc tgatggagct tgcgattctg aatggcacct acagagatgc caacattaaa tcaccagccc ttgccttttc tcttgcagca acagcccagg ctgctccaag gatcattact gggcctgcgc cggttctccc accagctgcc ctgcgtactc ctacgccagc tggccctacc ataatgcctt tgatcagaca aatacagacc gctgtcatgc caaacggaac tcctcaccca actgctgcaa tagttcctcc agggcccgaa gctggtttaa tctatacacc ctatgagtac ccctacacat tggcaccagc tacatcaatc cttgagtatc ctattgaacc tagtggtgta ttaggtgcgg tggctactaa agttcgaagg cacgatatgc gtgtccatcc ttaccaaagg attgtgaccg cagaccgagc cgccaccggc aactaa
Molecular Weight
35,131 Da
OMIM
609590
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of QKI cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for QKI. It may not necessarily be applicable to this product.

NCBI GI #
34783187
NCBI GeneID
9444
NCBI Accession #
BC019917
UniProt Secondary Accession #
Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9
UniProt Related Accession #
Q96PU8
NCBI Official Full Name
Homo sapiens quaking homolog, KH domain RNA binding (mouse), mRNA
NCBI Official Synonym Full Names
QKI, KH domain containing RNA binding
NCBI Official Symbol
QKI
NCBI Official Synonym Symbols
QK; Hqk; QK1; QK3; hqkI
UniProt Protein Name
Protein quaking
Protein Family
Protein quaking
UniProt Gene Name
QKI
UniProt Synonym Gene Names
HKQ; Hqk; HqkI
UniProt Entry Name
QKI_HUMAN
NCBI Protein Information
protein quaking

NCBI Summary for QKI

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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UniProt Comments for QKI

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q26

Molecular Function: protein binding
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Research Articles on QKI

1. QKI has a role in posttranscriptionally guiding macrophage identity and function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with QKI cdna clone

 Products by Pathway  Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram

Diseases associated with QKI cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with QKI and Neoplasms
 Nervous System Diseases Antibodies  >16 publications with QKI and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with QKI and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >2 publications with QKI and Ovarian Neoplasms
 Endometrial Neoplasms Antibodies  >2 publications with QKI and Endometrial Neoplasms
 Breast Neoplasms Antibodies  >2 publications with QKI and Breast Neoplasms
 Ataxia Antibodies  >2 publications with QKI and Ataxia
 Abnormalities, Multiple Antibodies  >2 publications with QKI and Abnormalities, Multiple
 Inflammation Antibodies  >2 publications with QKI and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with QKI and Cardiovascular Diseases

Organs/Tissues associated with QKI cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >37 publications with QKI and Brain
 Nerve Antibodies  >22 publications with QKI and Nerve
 Embryonic Tissue Antibodies  >8 publications with QKI and Embryonic Tissue
 Blood Antibodies  >7 publications with QKI and Blood
 Heart Antibodies  >6 publications with QKI and Heart
 Vascular Antibodies  >6 publications with QKI and Vascular
 Muscle Antibodies  >5 publications with QKI and Muscle
 Testis Antibodies  >2 publications with QKI and Testis
 Kidney Antibodies  >2 publications with QKI and Kidney
 Stomach Antibodies  >1 publications with QKI and Stomach
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