Human RAD23B cDNA Clone Expression Plasmid – Cat# MBS1265992

RAD23B cDNA Clone – RAD23 Homolog B (S. Cerevisiae) (Human)

Name: RAD23B cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265992
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265992

MBS1265992 is a cDNA clone targeting RAD23B. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAD23B, cDNA Clone

Full Product Name

RAD23B cDNA Clone

Product Gene Name

RAD23B cdna clone

Sequence

atgcaggtca ccctgaagac cctccagcag cagaccttca agatagacat tgaccccgag gagacggtga aagcactgaa agagaagatt gaatctgaaa aggggaaaga tgcctttcca gtagcaggtc aaaaattaat ttatgcaggc aaaatcctca atgatgatac tgctctcaaa gaatataaaa ttgatgagaa aaactttgtg gtggttatgg tgaccaaacc caaagcagtg tccacaccag caccagctac aactcagcag tcagctcctg ccagcactac agcagttact tcctccacca ccacaactgt ggctcaggct ccaacccctg tccctgcctt ggcccccact tccacacctg catccatcac tccagcatca gcgacagcat cttctgaacc tgcacctgct agtgcagcta aacaagagaa gcctgcagaa aagccagcag agacaccagt ggctactagc ccaacagcaa ctgacagtac atcgggtgat tcttctcggt caaacctttt tgaagatgca acgagtgcac ttgtgacggg tcagtcttac gagaatatgg taactgagat catgtcaatg ggctatgaac gagagcaagt aattgcagcc ctgagagcca gtttcaacaa ccctgacaga gcagtggagt atcttttaat gggaatccct ggagatagag aaagtcaggc tgtggttgac ccccctcaag cagctagtac tggggttcct cagtcttcag cagtggctgc agctgcagca actacgacag caacaactac aacaacaagt tctggaggac atccccttga atttttacgg aatcagcctc agtttcaaca gatgagacaa attattcagc agaatccttc cttgcttcca gcgttactac agcagatagg tcgagagaat cctcaattac ttcagcaaat tagccaacac caggagcatt ttattcagat gttaaatgaa ccagttcaag aagctggtgg tcaaggagga ggaggtggag gtggcagtgg aggaattgca gaagctggaa gtggtcatat gaactacatt caagtaacac ctcaggaaaa agaagctata gaaaggttaa aggcattagg atttcctgaa ggacttgtga tacaagcgta ttttgcttgt gagaagaatg agaatttggc tgccaatttt cttctacagc agaactttga tgaagattga

Molecular Weight

35,005 Da

OMIM

600062

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RAD23B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RAD23B. It may not necessarily be applicable to this product.

NCBI GI #

34190975

NCBI GeneID

5887

NCBI Accession #

BC020973

UniProt Secondary Accession #

Q7Z5K8; Q8WUB0; B3KWK8; G5E9P0

UniProt Related Accession #

P54727

NCBI Official Full Name

Homo sapiens RAD23 homolog B (S. cerevisiae), mRNA

NCBI Official Synonym Full Names

RAD23 homolog B, nucleotide excision repair protein

NCBI Official Symbol

RAD23B

NCBI Official Synonym Symbols

P58; HR23B; HHR23B

UniProt Protein Name

UV excision repair protein RAD23 homolog B

UniProt Synonym Protein Names

XP-C repair-complementing complex 58 kDa protein; p58

Protein Family

Ubiquitin receptor

UniProt Gene Name

RAD23B

UniProt Synonym Gene Names

HR23B; hHR23B; p58

UniProt Entry Name

RD23B_HUMAN

NCBI Protein Information

UV excision repair protein RAD23 homolog B

NCBI Summary for RAD23B

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

UniProt Comments for RAD23B

RAD23B: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Belongs to the RAD23 family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q31.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: polyubiquitin binding; protein binding; single-stranded DNA binding

Biological Process: nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, preincision complex assembly; regulation of proteasomal ubiquitin-dependent protein catabolic process

Research Articles on RAD23B

1. Data show that nucleotide excision repair factor XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 (PARP1).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RAD23B cdna clone

Products by Pathway	Pathway Diagram
DNA Damage Recognition In GG-NER Pathway antibodies	DNA Damage Recognition In GG-NER Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Dual Incision Reaction In GG-NER Pathway antibodies	Dual Incision Reaction In GG-NER Pathway Diagram
Formation Of Incision Complex In GG-NER Pathway antibodies	Formation Of Incision Complex In GG-NER Pathway Diagram
Global Genomic NER (GG-NER) Pathway antibodies	Global Genomic NER (GG-NER) Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with RAD23B cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>39 publications with RAD23B and Neoplasms
Precancerous Conditions Antibodies	>11 publications with RAD23B and Precancerous Conditions
Carcinoma Antibodies	>7 publications with RAD23B and Carcinoma
Liver Neoplasms Antibodies	>5 publications with RAD23B and Liver Neoplasms
Adenocarcinoma Antibodies	>5 publications with RAD23B and Adenocarcinoma
Nervous System Diseases Antibodies	>5 publications with RAD23B and Nervous System Diseases
Breast Neoplasms Antibodies	>4 publications with RAD23B and Breast Neoplasms
Brain Diseases Antibodies	>4 publications with RAD23B and Brain Diseases
Liver Diseases Antibodies	>4 publications with RAD23B and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>3 publications with RAD23B and Carcinoma, Hepatocellular

Organs/Tissues associated with RAD23B cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with RAD23B and Blood
Liver Antibodies	>5 publications with RAD23B and Liver
Muscle Antibodies	>5 publications with RAD23B and Muscle
Nerve Antibodies	>4 publications with RAD23B and Nerve
Lung Antibodies	>4 publications with RAD23B and Lung
Prostate Antibodies	>3 publications with RAD23B and Prostate
Testis Antibodies	>3 publications with RAD23B and Testis
Brain Antibodies	>3 publications with RAD23B and Brain
Skin Antibodies	>2 publications with RAD23B and Skin
Bladder Antibodies	>2 publications with RAD23B and Bladder