Human RASA1 cDNA Clone Expression Plasmid – Cat# MBS1266508

RASA1 cDNA Clone – RAS P21 Protein Activator (Gtpase Activating Protein) 1 (Human)

Name: RASA1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266508
Price: 1360 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266508

MBS1266508 is a cDNA clone targeting RASA1. More details

$1360 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RASA1, cDNA Clone

Full Product Name

RASA1 cDNA Clone

Product Gene Name

RASA1 cdna clone

Sequence

atgatggcgg ccgaggccgg cagtgaggag ggcggcccgg taacagccgg agctggagga ggcggcgcgg cagcgggctc cagtgcctat cccgcagtgt gtcgggtgaa gatacccgcg gccctgcctg tggcagccgc cccctatcct gggctggtgg agaccggagt ggctggaact ctgggtggcg gagccgcttt ggggtcagag ttcctaggag ccgggtctgt ggcaggggca ctggggggag ctggactgac agggggaggt actgctgctg gcgtagctgg tgctgctgct ggcgtggccg gtgctgctgt tgctggacct agtggagaca tggctctcac caaactgccc acttcgttgc ttgctgagac tctcgggcca ggcggcggtt ttccccctct gccccctccc ccttacctgc cccctttggg ggcgggcctc gggacagtgg acgaaggtga ctctctggat ggaccagaat acgaggagga agaggtggcc ataccgttga ccgctcctcc aactaaccag tggtatcacg gaaaacttga cagaacgata gcagaagaac gcctcaggca ggcagggaag tctggcagtt atcttataag agagagtgat cggaggccag ggtcctttgt actttcattt cttagccaga tgaatgttgt caaccatttt aggattattg ctatgtgtgg agattactac attggtggaa gacgtttttc ttcactgtca gacctaatag gttattacag tcatgtttct tgtttgctta aaggagaaaa attactttac ccagttgcac caccagagcc agtagaagat agaaggcgtg tacgagctat tctaccttac acaaaagtac cagacactga tgaaataagt ttcttaaaag gagatatgtt cattgttcat aatgaattag aagatggatg gatgtgggtt acaaatttaa gaacagatga acaaggcctt attgttgaag acctagtaga agaggtgggc cgggaagaag atccacatga aggaaaaata tggttccatg ggaagatttc caaacaggaa gcttataatt tactaatgac agttggtcaa gtctgcagtt ttcttgtgag gccctcagat aatactcctg gcgattattc actttatttc cggaccaatg aaaatattca gcgatttaaa atatgtccaa cgccaaacaa tcagtttatg atgggaggcc ggtattataa cagcattggg gacatcatag atcactatcg aaaagaacag attgttgaag gatattatct taaggaacct gtaccaatgc aggatcaaga acaagtactc aatgacacag tggatggcaa ggaaatctat aataccatcc gtcgtaaaac aaaggatgcc ttttataaaa acattgttaa gaaaggttat cttctgaaaa agggcaaagg aaaacgttgg aaaaatttat attttatctt agagggtagt gatgcccaac ttatttattt tgaaagcgaa aaacgagcta ccaaaccaaa aggattaata gatctcagtg tatgttctgt ctatgtcgtt catgatagtc tctttggcag gccaaactgt tttcagatag tagttcagca ctttagtgaa gaacattaca tcttttactt tgcaggagaa actccagaac aagcagagga ttggatgaaa ggtctgcagg cattttgcaa tttacggaaa agtagtccag ggacatccaa taaacgcctt cgtcaggtca gcagccttgt tttacatatt gaagaagccc ataaactccc agtaaaacat tttactaatc catattgtaa catctacctg aatagtgtcc aagtagcaaa aactcatgca agggaagggc aaaacccagt atggtcagaa gagtttgtct ttgatgatct tcctcctgac atcaatagat ttgaaataac tcttagtaat aaaacaaaga aaagcaaaga tcctgatatc ttatttatgc gctgccagtt gagccgatta cagaaagggc atgccacaga tgaatggttt ctgctcagct cccatatacc attaaaaggt attgaaccag ggtccctgcg tgttcgagca cgatactcta tggaaaaaat catgccagaa gaagagtaca gtgaatttaa agagcttata ctgcaaaagg aacttcatgt agtctatgct ttatcacatg tatgtggaca agaccgaaca ctactggcca gcatcctact gaggattttt cttcacgaaa agcttgaatc gttgttgtta tgcacactaa atgacagaga aataagcatg gaagatgaag ccactaccct atttcgagcc acaacacttg caagcacctt gatggagcag tatatgaaag ccactgctac acagtttgtt catcatgctt tgaaagactc tattttaaag ataatggaaa gcaagcagtc ttgtgagtta agtccatcaa agttagaaaa aaatgaagat gtgaacacta atttaacaca cctattgaac atactttcag agcttgtgga gaaaatattc atggcttcag aaatacttcc accgacattg agatatattt atgggtgttt acagaaatct gttcagcata agtggcctac aaataccacc atgagaacaa gagttgttag tggttttgtt tttcttcgac tcatctgtcc tgccatcctg aatccacgga tgttcaatat catctcagat tctccatctc ctattgctgc aagaacactg atattagtgg ctaaatctgt gcagaactta gcaaatcttg tggaatttgg agctaaggag ccctacatgg aaggtgtcaa tccattcatc aaaagcaaca aacatcgtat gatcatgttt ttagatgaac ttgggaatgt acctgaactt ccggacacta cagagcattc tagaacggac ctgtcccgtg atttagcagc attgcatgag atttgcgtgg ctcattcaga tgaacttcga acgctcagta atgagcgtgg tgcacagcag cacgtattga aaaagcttct ggctataaca gaactgcttc aacaaaaaca aaaccagtat acaaaaacca atgatgtcag gtag

Molecular Weight

101,546 Da

OMIM

139150

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RASA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RASA1. It may not necessarily be applicable to this product.

NCBI GI #

34190380

NCBI GeneID

5921

NCBI Accession #

BC033015

UniProt Secondary Accession #

Q68CU6; Q9UDI1; B2R6W3; B4DTL2

UniProt Related Accession #

P20936

NCBI Official Full Name

Homo sapiens RAS p21 protein activator (GTPase activating protein) 1, mRNA

NCBI Official Synonym Full Names

RAS p21 protein activator 1

NCBI Official Symbol

RASA1

NCBI Official Synonym Symbols

GAP; PKWS; RASA; p120; CMAVM; CM-AVM; RASGAP; p120GAP; p120RASGAP

UniProt Protein Name

Ras GTPase-activating protein 1

UniProt Synonym Protein Names

Ras p21 protein activator; p120GAP

Protein Family

Ras GTPase-activating protein

UniProt Gene Name

RASA1

UniProt Synonym Gene Names

GAP; RASA; GAP; GTPase-activating protein; RasGAP

UniProt Entry Name

RASA1_HUMAN

NCBI Protein Information

ras GTPase-activating protein 1

NCBI Summary for RASA1

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]

UniProt Comments for RASA1

RASA1: a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described.

Protein type: GAPs, Ras; GAPs; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: cytoplasm; cytosol

Molecular Function: glycoprotein binding; GTPase activator activity; GTPase binding; protein binding; receptor binding

Biological Process: blood vessel morphogenesis; cytokinesis after mitosis; embryonic development; ephrin receptor signaling pathway; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptosis; negative regulation of Ras protein signal transduction; regulation of actin filament polymerization; signal transduction; vasculogenesis

Disease: Basal Cell Carcinoma, Susceptibility To, 1; Capillary Malformation-arteriovenous Malformation; Parkes Weber Syndrome

Research Articles on RASA1

1. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RASA1 cdna clone

Products by Pathway	Pathway Diagram
Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies	Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
Aurora A Signaling Pathway antibodies	Aurora A Signaling Pathway Diagram
Aurora B Signaling Pathway antibodies	Aurora B Signaling Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
EGF Receptor (ErbB1) Signaling Pathway antibodies	EGF Receptor (ErbB1) Signaling Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram

Diseases associated with RASA1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>20 publications with RASA1 and Neoplasms
Cardiovascular Diseases Antibodies	>20 publications with RASA1 and Cardiovascular Diseases
Arteriovenous Malformations Antibodies	>19 publications with RASA1 and Arteriovenous Malformations
Capillary Malformation-Arteriovenous Malformation Antibodies	>16 publications with RASA1 and Capillary Malformation-Arteriovenous Malformation
Nervous System Diseases Antibodies	>12 publications with RASA1 and Nervous System Diseases
Hypertrophy Antibodies	>6 publications with RASA1 and Hypertrophy
Port-Wine Stain Antibodies	>5 publications with RASA1 and Port-Wine Stain
Sturge-Weber Syndrome Antibodies	>5 publications with RASA1 and Sturge-Weber Syndrome
Carcinoma Antibodies	>5 publications with RASA1 and Carcinoma
Brain Diseases Antibodies	>4 publications with RASA1 and Brain Diseases

Organs/Tissues associated with RASA1 cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>24 publications with RASA1 and Vascular
Brain Antibodies	>14 publications with RASA1 and Brain
Skin Antibodies	>11 publications with RASA1 and Skin
Blood Antibodies	>9 publications with RASA1 and Blood
Muscle Antibodies	>3 publications with RASA1 and Muscle
Eye Antibodies	>2 publications with RASA1 and Eye
Embryonic Tissue Antibodies	>2 publications with RASA1 and Embryonic Tissue
Heart Antibodies	>2 publications with RASA1 and Heart
Liver Antibodies	>2 publications with RASA1 and Liver
Bone Antibodies	>2 publications with RASA1 and Bone