Human RFX6 cDNA Clone Expression Plasmid – Cat# MBS1266685

RFX6 cDNA Clone – Regulatory Factor X, 6 (Human)

Name: RFX6 cDNA Clone; Regulatory Factor X, 6; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266685
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266685

MBS1266685 is a cDNA clone targeting RFX6. More details

$630 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RFX6, cDNA Clone

Full Product Name

RFX6 cDNA Clone

Product Gene Name

RFX6 cdna clone

Sequence

atggccaagg tcccgaagct ggaagacacc ttcctgcagg cgcagcctgc gccccaactg tccccgggga tccaggaaga ctgctgtgtg cagctcctgg gcaagggctt gctagtctat ccggaagaaa cagtgtacct ggcggccgaa gggcagcccg ggggcgagca gggcggcggg gagaaaggcg aagacccgga gctgccgggg gcagtgaaat cagaaatgca cttaaacaat ggtaactttt cctctgaaga agaggacgcc gacaaccacg acagcaaaac caaagcagcg gatcaatacc tgtctcagaa gaaaaccatc acgcagattg tgaaggataa aaagaagcag acacagctca cgctgcagtg gcttgaagag aattacattg tatgtgaagg agtttgctta ccacggtgca ttctttatgc acactactta gatttctgta ggaaagagaa attagagcca gcctgtgcgg ccacctttgg aaagacaatt cgccagaagt ttcccctcct aacaacaagg cggcttggaa caagaggcca ttcaaagtat cattactatg ggattggcat caaagagagc agtgcatatt accactccgt ttattctgga aagggcttga caaggttttc tggaagcaag ctaaagaatg agggtggctt cactcgtaaa tattcgctta gctcaaaaac tggaacactt cttccagaat tccccagcgc tcaacacctt gtataccaag gatgcatttc taaggacaag gttgatacgc tcataatgat gtacaaaact cactgccagt gtatcctgga caatgcaatt aatggaaact ttgaagagat ccagcatttt ttattacact tttggcaagg aatgcctgac catctccttc ccctgctcga aaatcctgtt atcattgata ttttctgtgt ttgtgactca attctttata aggttcttac agatgtactc attcctgcaa caatgcaaga aatgcctgaa agcttattag cagacataag aaattttgct aaaaattggg aacagtgggt tgtttcatcc ttggaaaact tgccagaagc tctaactgac aagaaaatac ctattgtgcg aagatttgta tcttctctga aacgacaaac atctttctta catcttgccc agattgccag accagctctc tttgaccagc atgtcgttaa ttctatggtg tctgatattg aaagggttga tttgaacagc attggctctc aagcccttct taccatttca ggcagcacag acactgaatc tggtatctac actgaacatg actctatcac tgtgttccaa gaactgaagg atctccttaa gaagaatgcc actgtggagg cttttattga atggttggat actgtggtag aacagagagt tattaagacc agcaaacaaa atggaaggtc attaaagaag agagctcaag actttctgtt aaagtggagt ttttttggtg ctcgagtaat gcataatctc accttgaaca atgcatccag ttttggttct tttcatttga ttcgaatgct tctcgatgaa tacattctcc tggccatgga gacccagttt aataatgaca aagagcagga gttacagaat ttattggaca agtatatgaa gaattcagat gcgagtaaag ctgctttcac tgcttctccg agttcatgct ttctggccaa ccgtaataaa gggagcatgg tttccagcga cgctgtgaag aatgaaagcc acgtggagac aacctatctc cctctgccat ccagtcaacc tggaggccta ggccctgctc tgcaccagtt ccctgctggg aacacagaca acatgccgct cacaggtcaa atggagcttt cacagattgc tggtcatctg atgacaccac ccatttctcc agccatggca agccgaggaa gtgtcattaa ccaaggacca atggcaggga ggcccccaag tgtgggccca gtactgtcag ctccatcaca ctgctccaca tacccagagc ccatttatcc cgctctccct caagccaatc atgactttta tagcaccagc tctaactacc agactgtgtt tagggcacag ccccactcca catcaggact ctatcctcat cacaccgagc atggtcgatg catggcttgg actgaacagc agctttcaag agacttcttc agtggcagct gtgcggggtc tccatataac tcccggccac cgtctagcta tggcccatcc ctgcaagccc aggattcaca caatatgcag tttttaaata caggaagctt caatttcttg agcaacacag gagctgccag ctgccaagga gcaacactgc ctcctaattc accaaatgga tactatggaa gcaacataaa ctacccagag tctcacaggc tcggatcaat ggtgaatcag cacgtttctg tcatcagcag cattcgttca ctgcccccct acagtgacat ccacgatcca cttaacattt tagatgacag tggtagaaaa cagaccagct cgttttacac agacacatca tctccagttg catgtcgaac tccagtccta gcttccagtt tgcaaacccc aattccttct tcctcatccc aatgtatgta tggaacttcc aaccagtatc cagctcaaga aaccctggac tcccatggaa caagcagtag agaaatggtg tcctctttac cacctatcaa cactgtgttc atgggaacag cagctggagg cacttaa

Molecular Weight

102,461 Da

OMIM

612659

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RFX6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RFX6. It may not necessarily be applicable to this product.

NCBI GI #

24660189

NCBI GeneID

222546

NCBI Accession #

BC039248

UniProt Secondary Accession #

Q5T6B3

UniProt Related Accession #

Q8HWS3

NCBI Official Full Name

Homo sapiens regulatory factor X, 6, mRNA

NCBI Official Synonym Full Names

regulatory factor X6

NCBI Official Symbol

RFX6

NCBI Official Synonym Symbols

MTFS; MTCHRS; RFXDC1; dJ955L16.1

UniProt Protein Name

DNA-binding protein RFX6

UniProt Synonym Protein Names

Regulatory factor X 6; Regulatory factor X domain-containing protein 1

Protein Family

DNA-binding protein

UniProt Gene Name

RFX6

UniProt Synonym Gene Names

RFXDC1

UniProt Entry Name

RFX6_HUMAN

NCBI Protein Information

DNA-binding protein RFX6

NCBI Summary for RFX6

The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]

UniProt Comments for RFX6

RFX6: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Defects in RFX6 are the cause of the Mitchell-Riley syndrome (MIRIS). The Mitchell-Riley syndrome is characterized by neonatal diabetes, hypoplastic or annular pancreas, duodenal and jejunal atresia, and absent gallbladder. There are no dysmorphic features. Patients usually die in the first year of life despite aggressive medical management. Belongs to the RFX family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: endocrine pancreas development; glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of insulin secretion

Disease: Mitchell-riley Syndrome

Research Articles on RFX6

1. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with RFX6 cdna clone

Disease Name	Pubmed Publications
Prostatic Neoplasms Antibodies	>3 publications with RFX6 and Prostatic Neoplasms
Kidney Diseases Antibodies	>1 publications with RFX6 and Kidney Diseases
Hyperplasia Antibodies	>1 publications with RFX6 and Hyperplasia
Heart Defects, Congenital Antibodies	>1 publications with RFX6 and Heart Defects, Congenital

Organs/Tissues associated with RFX6 cdna clone

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>11 publications with RFX6 and Pancreas
Prostate Antibodies	>5 publications with RFX6 and Prostate
Connective Tissue Antibodies	>1 publications with RFX6 and Connective Tissue
Lung Antibodies	>1 publications with RFX6 and Lung