Human RGNEF cDNA Clone Expression Plasmid – Cat# MBS1272434

RGNEF cDNA Clone – Rho-Guanine Nucleotide Exchange Factor (Human)

Name: RGNEF cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272434
Price: 715 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272434

MBS1272434 is a cDNA clone targeting RGNEF. More details

$715 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RGNEF, cDNA Clone

Full Product Name

RGNEF cDNA Clone

Product Gene Name

RGNEF cdna clone

Sequence

atgattgcaa cagtggattt aaaagtcaat gaatatgaga aaaaccaaaa atggcttgag atcctaaata agattgaaaa caaaacatac acgaagctca aaaatggaca tgtgtttagg aagcaggcac tgatgagtga agaaaggact ctgttatatg atggccttgt ttactggaaa actgctacag gtcgtttcaa agatatccta gctctacttc taactgatgt gctgctcttt ttacaagaaa aagaccagaa atacatcttt gcagccgttg atcagaagcc atcagttatt tcccttcaaa agcttattgc tagagaagtt gctaatgagg agagaggaat gtttctgatc agtgcttcat ctgctggtcc tgagatgtat gaaattcaca ccaattccaa ggaggaacgc aataactgga tgagacggat ccagcaggct gtagaaagtt gtcctgaaga aaaaggggga aggacaagtg aatctgatga agacaagagg aaagctgaag ccagagtggc caaaattcag caatgtcaag aaatactcac taaccaagac caacaaattt gtgcgtattt ggaggagaag ctgcatatct atgctgaact tggagaactg agcggatttg aggacgtcca tctagagccc cacctcctta ttaaacctga cccaggcgag cctccccagg cagcctcatt actggcagca gcactgaaag aagctgagag cctacaagtt gcagtgaagg cctcacagat gggcgccgtg agtcaatcat gtgaggacag ttgtggagac tctgtcttgg cggacacact cagttctcat gatgtaccag gatcaccgac tgcctcatta gtcacaggag ggagagaagg aagaggctgt tcggatgtgg atcccgggat ccagggtgtg gtaaccgact tggccgtctc tgatgcaggg gagaaggtgg aatgtagaaa ttttccaggt tcttcacaat cagagattat acaagccata cagaatttaa cccgtctctt atacagcctt caggccgcct tgaccattca ggacagccac attgagatcc acaggctggt tctccagcag caggagggcc tgtctctcgg ccactctatc ctccgaggcg gccccttgca ggaccagaag tctcgcgacg cggacaggca gcatgaggag ctggccaatg tgcaccagct tcagcaccag ctccagcagg agcagcggcg ctggctgcgc aggtgtgagc agcagcagcg ggcgcaggcg accagggaga gctggctgca ggagcgggag cgggagtgcc agtcgcagga ggagctgctg ctgcggagcc ggggcgagct ggacctccag ctccaggagt accagcacag cctggagcgg ctgagggagg gccagcgcct ggtggagagg gagcaggcga ggatgcgggc ccagcagagc ctgctgggcc actggaagca cggccggcag aggagcctgc ccgcggtgct ccttccgggt ggccccgagg taatggaact taaccgatct gagagtttat gtcatgaaaa ctcattcttc atcaatgaag ctttagtaca aatgtcattt aacactttca acaaactgaa tccatcagtt atccatcagg atgccactta ccctacaact caatttcatt ctgacttggt gaggactagt gaacatcaag tagacctcct ggtggaccct tctcagcctt tgaatgtcag tcacaaactg tggacagccg ctggttccgg ccatcagata cttcctttcc atgaaagcag caaggattct tgtaaaaatg gtaattaa

Molecular Weight

194,519 Da

OMIM

612790

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RGNEF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RGNEF. It may not necessarily be applicable to this product.

NCBI GI #

15341760

NCBI GeneID

64283

NCBI Accession #

BC012946

UniProt Secondary Accession #

Q8NCM7; Q96E37; Q9H6L3; Q9H6W0; B2RXG7; B4E3K4; B5MDA3; B7ZW32; E9PC75

UniProt Related Accession #

Q8N1W1

NCBI Official Full Name

Homo sapiens Rho-guanine nucleotide exchange factor, mRNA

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor 28

NCBI Official Symbol

ARHGEF28

NCBI Official Synonym Symbols

RIP2; RGNEF; p190RHOGEF

UniProt Protein Name

Rho guanine nucleotide exchange factor 28

UniProt Synonym Protein Names

190 kDa guanine nucleotide exchange factor; p190-RhoGEF; p190RhoGEF; Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF28

UniProt Synonym Gene Names

KIAA1998; RGNEF; p190-RhoGEF; p190RhoGEF

UniProt Entry Name

ARG28_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 28

NCBI Summary for RGNEF

This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

UniProt Comments for RGNEF

RGNEF: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; Cell development/differentiation; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: cytosol

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway

Research Articles on RGNEF

1. results show that Rgnef functions as an effector of Galpha13 signaling and that this linkage may mediate FAK activation in DLD-1 colon carcinoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RGNEF cdna clone

Products by Pathway	Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram
Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies	Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram

Organs/Tissues associated with RGNEF cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with RGNEF and Brain