Human RIN2 cDNA Clone Expression Plasmid – Cat# MBS1269601

RIN2 cDNA Clone – Rab Interactor 2 (Human)

Name: RIN2 cDNA Clone; Rab Interactor 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269601
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269601

MBS1269601 is a cDNA clone targeting RIN2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RIN2, cDNA Clone

Full Product Name

RIN2 cDNA Clone

Product Gene Name

RIN2 cdna clone

Sequence

ATGACAGCTT GGACCATGGG CGCCCGCGGT CTGGACAAGC GAGGAAGTTT CTTTAAGCTC ATTGACACAA TTGCCTCGGA GATCGGAGAA CTGAAACAGG AGATGGTGCG GACAGATGTC AACCTGGAAA ATGGCCTGGA ACCCGCTGAA ACCCACAGCA TGGTAAGACA CAAGGATGGT GGCTATTCCG AGGAAGAGGA CGTGAAGACC TGTGCCCGGG ACTCAGGCTA TGACAGCCTC TCCAACAGGC TCAGCATCTT GGACCGGCTC CTCCACACCC ACCCCATATG GCTGCAGCTG AGTCTGAGTG AGGAGGAGGC AGCAGAGGTC CTGCAGGCCC AGCCTCCGGG GATCTTCCTG GTTCATAAAT CTACCAAGAT GCAGAAGAAA GTCCTCTCCC TCCGCCTGCC CTGTGAATTT GGGGCCCCAC TCAAGGAATT TGCCATAAAG GAAAGCACAT ACAATGTGGT GCTGGAAAAA GCCATGCACA AGTGCATCTT GAAGCCCCTC AAGGGGCATG TGGAGGCCAT GCTGAAGGAC TTTCACATGG CCGATGGCTC ATGGAAGCAA CTCAAGGAGA ACCTGCAGCT TGTGCGGCAG AGGAATCCGC AGGAGCTGGG GGTCTTCGCC CCGACCCCTG ATTTTGTGGA TGTGGAGAAA ATCAAAGTCA AGTTCATGAC CATGCAGAAG ATGTATTCGC CGGAAAAGAA GGTCATGCTG CTGCTGCGGG TCTGCAAGCT CATTTACACG GTCATGGAGA ACAACTCAGG GAGGATGTAT GGCGCTGATG ACTTCTTGCC AGTCCTGACC TATGTCATAG CCCAGTGTGA CATGCTTGAA TTGGACACTG AAATCGAGTA CATGATGGAG CTCCTAGACC CATCGCTGTT ACATGGAGAA GGAGGCTATT ACTTGACAAG CGCATATGGA GCACTTTCTC TGATAAAGAA TTTCCAAGAA GAACAAGCAG CGCGACTGCT CAGCTCAGAA ACCAGAGACA CCCTGAGGCA GTGGCACAAA CGGAGAACCA CCAACCGGAC CATCCCCTCT GTGGACGACT TCCAGAATTA CCTCCGAGTT GCATTTCAGG AGGTCAACAG TGGTTGCACA GGAAAGACCC TCCTTGTGAG ACCTTACATC ACCACTGAGG ATGTGTGTCA GATCTGCACT GAGAAGTTCA AGGTGGGGGA CCCTGAGGAG TACAGCCTCT TTCTCTTCGT TGACGAGACA TGGCAGCAGC TGGCAGAGGA CACTTACCCT CAAAAAATCA AGGCGGAGCT GCACAGCCGA CCACAGCCCC ACATCTTCCA CTTTGTCTAC AAACGCATCA AGAACGATCC TTATGGCATC ATTTTCCAGA ACGGGGAAGA AGACCTCACC ACCTCCTAG

Molecular Weight

105,613 Da

OMIM

610222

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RIN2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RIN2. It may not necessarily be applicable to this product.

NCBI GI #

118764174

NCBI GeneID

54453

NCBI Accession #

BC128065

UniProt Secondary Accession #

Q00425; Q5TFT8; Q9BQL3; Q9H071

UniProt Related Accession #

Q8WYP3

NCBI Official Full Name

Homo sapiens Ras and Rab interactor 2, mRNA

NCBI Official Synonym Full Names

Ras and Rab interactor 2

NCBI Official Symbol

RIN2

NCBI Official Synonym Symbols

MACS; RASSF4

UniProt Protein Name

Ras and Rab interactor 2

UniProt Synonym Protein Names

Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2

Protein Family

E3 ubiquitin protein ligase

UniProt Gene Name

RIN2

UniProt Synonym Gene Names

RASSF4

UniProt Entry Name

RIN2_HUMAN

NCBI Protein Information

ras and Rab interactor 2

NCBI Summary for RIN2

The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

UniProt Comments for RIN2

RIN2: Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Defects in RIN2 are the cause of MACS syndrome (MACS); also called macrocephaly alopecia cutis laxa and scoliosis syndrome. MACS is an autosomal-recessive inherited complex disorder of elastic tissue, characterized by sagging skin and occasionally by life-threatening visceral complications. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GEFs, Rab; GEFs

Chromosomal Location of Human Ortholog: 20p11.22

Disease: Macs Syndrome

Research Articles on RIN2

1. We describe the fourth family with RIN2 syndrome in two siblings with a novel homozygous mutation in the RIN2 gene and exhibiting additional clinical features that may also contribute to further delineation of the phenotypic spectrum.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RIN2 cdna clone

Products by Pathway	Pathway Diagram
Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway antibodies	Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway Diagram

Diseases associated with RIN2 cdna clone

Disease Name	Pubmed Publications
Alopecia Antibodies	>2 publications with RIN2 and Alopecia
Congenital Abnormalities Antibodies	>2 publications with RIN2 and Congenital Abnormalities
Macrocephaly, Alopecia, Cutis Laxa, and Scoliosis Antibodies	>2 publications with RIN2 and Macrocephaly, Alopecia, Cutis Laxa, and Scoliosis
Brain Diseases Antibodies	>1 publications with RIN2 and Brain Diseases
Abnormalities, Multiple Antibodies	>1 publications with RIN2 and Abnormalities, Multiple
Hypertrophy Antibodies	>1 publications with RIN2 and Hypertrophy
Neoplasms Antibodies	>1 publications with RIN2 and Neoplasms

Organs/Tissues associated with RIN2 cdna clone

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>3 publications with RIN2 and Skin
Blood Antibodies	>3 publications with RIN2 and Blood
Vascular Antibodies	>3 publications with RIN2 and Vascular
Connective Tissue Antibodies	>2 publications with RIN2 and Connective Tissue
Bone Antibodies	>1 publications with RIN2 and Bone
Kidney Antibodies	>1 publications with RIN2 and Kidney