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RNASEL cDNA Clone – Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272159

MBS1272159 is a cDNA clone targeting RNASEL. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RNASEL, cDNA Clone
Full Product Name
RNASEL cDNA Clone
Product Gene Name
RNASEL cdna clone
Sequence
ATGGAGAGCA GGGATCATAA CAACCCCCAG GAGGGACCCA CGTCCTCCAG CGGTAGAAGG GCTGCAGTGG AAGACAATCA CTTGCTGATT AAAGCTGTTC AAAACGAAGA TGTTGACCTG GTCCAGCAAT TGCTGGAAGG TGGAGCCAAT GTTAATTTCC AGGAAGAGGA AGGGGGCTGG ACACCTCTGC ATAACGCAGT ACAAATGAGC AGGGAGGACA TTGTGGAACT TCTGCTTCGT CATGGTGCTG ACCCTGTTCT GAGGAAGAAG AATGGGGCCA CGCCTTTTAT CCTCGCAGCG ATTGCGGGGA GCGTGAAGCT GCTGAAACTT TTCCTTTCTA AAGGAGCAGA TGTCAATGAG TGTGATTTTT ATGGCTTCAC AGCCTTCATG GAAGCCGCTG TGTATGGTAA GGTCAAAGCC CTAAAATTCC TTTATAAGAG AGGAGCAAAT GTGAATTTGA GGCGAAAGAC AAAGGAGGAT CAAGAGCGGC TGAGGAAAGG AGGGGCCACA GCTCTCATGG ACGCTGCTGA AAAAGGACAC GTAGAGGTCT TGAAGATTCT CCTTGATGAG ATGGGGGCAG ATGTAAACGC CTGTGACAAT ATGGGCAGAA ATGCCTTGAT CCATGCTCTC CTGAGCTCTG ACGATAGTGA TGTGGAGGCT ATTACGCATC TGCTGCTGGA CCATGGGGCT GATGTCAATG TGAGGGGAGA AAGAGGGAAG ACTCCCCTGA TCCTGGCAGT GGAGAAGAAG CACTTGGGTT TGGTGCAGAG GCTTCTGGAG CAAGAGCACA TAGAGATTAA TGACACAGAC AGTGATGGCA AAACAGCACT GCTGCTTGCT GTTGAACTCA AACTGAAGAA AATCGCCGAG TTGCTGTGCA AACGTGGAGC CAGTACAGAT TGTGGGGATC TTGTTATGAC AGCGAGGCGG AATTATGACC ATTCCCTTGT GAAGGTTCTT CTCTCTCATG GAGCCAAAGA AGATTTTCAC CCTCCTGCTG AAGACTGGAA GCCTCAGAGC TCACACTGGG GGGCAGCCCT GAAGGATCTC CACAGAATAT ACCGCCCTAT GATTGGCAAA CTCAAGTTCT TTATTGATGA AAAATACAAA ATTGCTGATA CTTCAGAAGG AGGCATCTAC CTGGGGTTCT ATGAGAAGCA AGAAGTAGCT GTGAAGACGT TCTGTGAGGG CAGCCCACGT GCACAGCGGG AAGTCTCTTG TCTGCAAAGC AGCCGAGAGA ACAGTCACTT GGTGACATTC TATGGGAGTG AGAGCCACAG GGGCCACTTG TTTGTGTGTG TCACCCTCTG TGAGCAGACT CTGGAAGCGT GTTTGGATGT GCACAGAGGG GAAGATGTGG AAAATGAGGA AGATGAATTT GCCCAAAATG TCCTGTCATC TATATTTAAG GCTGTTCAAG AACTACACTT GTCCTGTGGA TACACCCACC AGGATCTGCA ACCACAAAAC ATCTTAATAG ATTCTAAGAA AGCTGCTCAC CTGGCAGATT TTGATAAGAG CATCAAGTGG GCTGGAGATC CACAGGAAGT CAAGAGAGAT CTAGAGGACC TTGGACGGCT GGTCCTCTAT GTGGTAAAGA AGGGAAGCAT CTCATTTGAG GAGCTGAAAG CTCAAAGTAA TGAAGAGGTG GTTCAACTTT CTCCAGATGA GGAAACTAAG GACCTCATTC ATCGTCTCTT CCATCCTGGG GAACATGTGA GGGACTGTCT GAGTGACCTG CTGGGTCATC CCTTCTTTTG GACTTGGGAG AGCCGCTATA GGACGCTTCG GAATGTGGGA AATGAATCCG ACATCAAAAC ACGAAAATCT GAAAGTGAGA TCCTCAGACT ACTGCAACCT GGGCCTTCTG AACATTCCAA AAGTTTTGAC AAGTGGACGA CTAAGATTAA TGAATGTGTT ATGAAAAAAA TGAATAAGTT TTATGAAAAA AGAGGCAATT TCTACCAGAA CACTGTGGGT GATCTGCTAA AGTTCATCCG GAATTTGGGA GAACACATTG ATGAAGAAAA GCATAAAAAG ATGAAATTAA AAATTGGAGA CCCTTCCCTG TATTTTCAGA AGACATTTCC AGATCTGGTG ATCTATGTCT ACACAAAACT ACAGAACACA GAATATAGAA AGCATTTCCC CCAAACCCAC AGTCCAAACA AGCCTCAGTG TGATGGAGCT GGTGGGGCCA GTGGGTTGGC CAGCCCTGGG TGCTGA
Molecular Weight
73,416 Da
OMIM
176807
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RNASEL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RNASEL. It may not necessarily be applicable to this product.

NCBI GI #
92110214
NCBI GeneID
6041
NCBI Accession #
BC115697
UniProt Secondary Accession #
Q5W0L2; Q6AI46
UniProt Related Accession #
Q05823
NCBI Official Full Name
Homo sapiens ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent), mRNA
NCBI Official Synonym Full Names
ribonuclease L
NCBI Official Symbol
RNASEL
NCBI Official Synonym Symbols
RNS4; PRCA1
UniProt Protein Name
2-5A-dependent ribonuclease
UniProt Synonym Protein Names
Ribonuclease 4; Ribonuclease L; RNase L
Protein Family
2-5A-dependent ribonuclease
UniProt Gene Name
RNASEL
UniProt Synonym Gene Names
RNS4; 2-5A-dependent RNase; RNase L
UniProt Entry Name
RN5A_HUMAN
NCBI Protein Information
2-5A-dependent ribonuclease

NCBI Summary for RNASEL

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
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UniProt Comments for RNASEL

RNASEL: a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.

Protein type: Protein kinase, Other; EC 3.1.26.-; Ribonuclease; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cytosol; mitochondrial matrix

Molecular Function: protein binding; RNA binding

Biological Process: defense response to virus; negative regulation of viral genome replication; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport

Disease: Prostate Cancer, Hereditary, 1
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Research Articles on RNASEL

1. Data show that RNA decay by ribonuclease L (RNase L) has an important role in homeostasis and serves as a suppressor of cell adhesion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RNASEL cdna clone

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with RNASEL cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >86 publications with RNASEL and Neoplasms
 Prostatic Diseases Antibodies  >71 publications with RNASEL and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >71 publications with RNASEL and Prostatic Neoplasms
 Inflammation Antibodies  >14 publications with RNASEL and Inflammation
 Breast Neoplasms Antibodies  >11 publications with RNASEL and Breast Neoplasms
 Drug Toxicity Antibodies  >4 publications with RNASEL and Drug Toxicity
 Necrosis Antibodies  >4 publications with RNASEL and Necrosis
 Autoimmune Diseases Antibodies  >2 publications with RNASEL and Autoimmune Diseases
 Hyperplasia Antibodies  >2 publications with RNASEL and Hyperplasia
 Liver Diseases Antibodies  >2 publications with RNASEL and Liver Diseases

Organs/Tissues associated with RNASEL cdna clone

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >85 publications with RNASEL and Prostate
 Lung Antibodies  >3 publications with RNASEL and Lung
 Kidney Antibodies  >3 publications with RNASEL and Kidney
 Vascular Antibodies  >2 publications with RNASEL and Vascular
 Brain Antibodies  >2 publications with RNASEL and Brain
 Bone Antibodies  >2 publications with RNASEL and Bone
 Uncharacterized Tissue Antibodies  >1 publications with RNASEL and Uncharacterized Tissue
 Bladder Antibodies  >1 publications with RNASEL and Bladder
 Skin Antibodies  >1 publications with RNASEL and Skin
 Nerve Antibodies  >1 publications with RNASEL and Nerve
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