Human SERPING1 cDNA Clone Expression Plasmid – Cat# MBS1273149

SERPING1 cDNA Clone – Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (Human)

Name: SERPING1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273149
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273149

MBS1273149 is a cDNA clone targeting SERPING1. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SERPING1, cDNA Clone

Full Product Name

SERPING1 cDNA Clone

Product Gene Name

SERPING1 cdna clone

Sequence

atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcatg ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc tga

Molecular Weight

55,769 Da

OMIM

106100

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SERPING1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.

NCBI GI #

34783172

NCBI GeneID

710

NCBI Accession #

BC011171

UniProt Secondary Accession #

Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2

UniProt Related Accession #

P05155

NCBI Official Full Name

Homo sapiens serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, mRNA

NCBI Official Synonym Full Names

serpin family G member 1

NCBI Official Symbol

SERPING1

NCBI Official Synonym Symbols

C1IN; C1NH; HAE1; HAE2; C1INH

UniProt Protein Name

Plasma protease C1 inhibitor

UniProt Synonym Protein Names

C1 esterase inhibitor; C1-inhibiting factor; Serpin G1

Protein Family

Plasma protease C1 inhibitor

UniProt Gene Name

SERPING1

UniProt Synonym Gene Names

C1IN; C1NH; C1 Inh; C1Inh

UniProt Entry Name

IC1_HUMAN

NCBI Protein Information

plasma protease C1 inhibitor

NCBI Summary for SERPING1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPING1

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding; serine-type endopeptidase inhibitor activity

Biological Process: blood circulation; blood coagulation, intrinsic pathway; negative regulation of complement activation, lectin pathway; platelet degranulation

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of

Research Articles on SERPING1

1. This family-based study provides the first evidence that multiple amino acid substitutions in SERPING1 could influence Hereditary angioedema due to C1-inhibitor deficiency phenotype

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SERPING1 cdna clone

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway antibodies	Intrinsic Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram

Diseases associated with SERPING1 cdna clone

Disease Name	Pubmed Publications
Angioedemas, Hereditary Antibodies	>69 publications with SERPING1 and Angioedemas, Hereditary
Edema Antibodies	>52 publications with SERPING1 and Edema
Inflammation Antibodies	>21 publications with SERPING1 and Inflammation
Hereditary Angioedema Types I and II Antibodies	>11 publications with SERPING1 and Hereditary Angioedema Types I and II
Disease Models, Animal Antibodies	>10 publications with SERPING1 and Disease Models, Animal
Acquired angioedema Antibodies	>10 publications with SERPING1 and Acquired angioedema
Brain Diseases Antibodies	>8 publications with SERPING1 and Brain Diseases
Necrosis Antibodies	>7 publications with SERPING1 and Necrosis
Heart Diseases Antibodies	>5 publications with SERPING1 and Heart Diseases
Kidney Diseases Antibodies	>4 publications with SERPING1 and Kidney Diseases

Organs/Tissues associated with SERPING1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>75 publications with SERPING1 and Blood
Vascular Antibodies	>23 publications with SERPING1 and Vascular
Skin Antibodies	>22 publications with SERPING1 and Skin
Larynx Antibodies	>14 publications with SERPING1 and Larynx
Eye Antibodies	>8 publications with SERPING1 and Eye
Heart Antibodies	>6 publications with SERPING1 and Heart
Liver Antibodies	>5 publications with SERPING1 and Liver
Kidney Antibodies	>4 publications with SERPING1 and Kidney
Intestine Antibodies	>4 publications with SERPING1 and Intestine
Muscle Antibodies	>4 publications with SERPING1 and Muscle