Human SHMT2 cDNA Clone Expression Plasmid – Cat# MBS1266049

SHMT2 cDNA Clone – Serine Hydroxymethyltransferase 2 (Mitochondrial) (Human)

Name: SHMT2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266049
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266049

MBS1266049 is a cDNA clone targeting SHMT2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SHMT2, cDNA Clone

Full Product Name

SHMT2 cDNA Clone

Product Gene Name

SHMT2 cdna clone

Sequence

atgctgtact tctctttgtt ttgggcggct cggcctctgc agagatgtgg gcagctggtc aggatggcca ttcgggctca gcacagcaac gcagcccaga ctcagactgg ggaagcaaac aggggctgga caggccagga gagcctgtcg gacagtgatc ctgagatgtg ggagttgctg cagagggaga aggacaggca gtgtcgtggc ctggagctca ttgcctcaga gaacttctgc agccgagctg cgctggaggc cctggggtcc tgtctgaaca acaagtactc ggagggttat cctggcaaga gatactatgg gggagcagag gtggtggatg aaattgagct gctgtgccag cgccgggcct tggaagcctt tgacctggat cctgcacagt ggggagtcaa tgtccagccc tactccgggt ccccagccaa cctggccgtc tacacagccc ttctgcaacc tcacgaccgg atcatggggc tggacctgcc cgatgggggc catctcaccc acggctacat gtctgacgtc aagcggatat cagccacgtc catcttcttc gagtctatgc cctataagct caaccccaaa actggcctca ttgactacaa ccagctggca ctgactgctc gacttttccg gccacggctc atcatagctg gcaccagcgc ctatgctcgc ctcattgact acgcccgcat gagagaggtg tgtgatgaag tcaaagcaca cctgctggca gacatggccc acatcagtgg cctggtggct gccaaggtga ttccctcgcc tttcaagcac gcggacatcg tcaccaccac tactcacaag actcttcgag gggccaggtc agggctcatc ttctaccgga aaggggtgaa ggctgtggac cccaagactg gccgggagat cccttacaca tttgaggacc gaatcaactt tgccgtgttc ccatccctgc aggggggccc ccacaatcat gccattgctg cagtagctgt ggccctaaag caggcctgca cccccatgtt ccgggagtac tccctgcagg ttctgaagaa tgctcgggcc atggcagatg ccctgctaga gcgaggctac tcactggtat caggtggtac tgacaaccac ctggtgctgg tggacctgcg gcccaagggc ctggatggag ctcgggctga gcgggtgcta gagcttgtat ccatcactgc caacaagaac acctgtcctg gagaccgaag tgccatcaca ccgggcggcc tgcggcttgg ggccccagcc ttaacttctc gacagttccg tgaggatgac ttccggagag ttgtggactt tatagatgaa ggggtcaaca ttggcttaga ggtgaagagc aagactgcca agctccagga tttcaaatcc ttcctgctta aggactcaga aacaagtcag cgtctggcca acctcaggca acgggtggag cagtttgcca gggccttccc catgcctggt tttgatgagc attga

Molecular Weight

53,455 Da

OMIM

138450

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SHMT2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SHMT2. It may not necessarily be applicable to this product.

NCBI GI #

40225518

NCBI GeneID

6472

NCBI Accession #

BC011911

UniProt Secondary Accession #

O00740; Q8N1A5; B7Z9F1; E7EQ19; E7EU43

UniProt Related Accession #

P34897

NCBI Official Full Name

Homo sapiens serine hydroxymethyltransferase 2 (mitochondrial), mRNA

NCBI Official Synonym Full Names

serine hydroxymethyltransferase 2

NCBI Official Symbol

SHMT2

NCBI Official Synonym Symbols

GLYA; SHMT; HEL-S-51e

UniProt Protein Name

Serine hydroxymethyltransferase, mitochondrial

UniProt Synonym Protein Names

Glycine hydroxymethyltransferase; Serine methylase

UniProt Gene Name

SHMT2

UniProt Synonym Gene Names

SHMT

UniProt Entry Name

GLYM_HUMAN

NCBI Protein Information

serine hydroxymethyltransferase, mitochondrial

NCBI Summary for SHMT2

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

UniProt Comments for SHMT2

SHMT2: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.2.1; Energy Metabolism - methane; Other Amino Acids Metabolism - cyanoamino acid; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; Methyltransferase

Chromosomal Location of Human Ortholog: 12q12-q14

Cellular Component: cytoplasm; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleus

Molecular Function: chromatin binding; glycine hydroxymethyltransferase activity; protein binding; pyridoxal phosphate binding

Biological Process: folic acid metabolic process; glycine metabolic process; L-serine metabolic process; one-carbon compound metabolic process; protein tetramerization; tetrahydrofolate metabolic process

Research Articles on SHMT2

1. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SHMT2 cdna clone

Products by Pathway	Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
C1-unit Interconversion, Eukaryotes Pathway antibodies	C1-unit Interconversion, Eukaryotes Pathway Diagram
C1-unit Interconversion, Eukaryotes Pathway antibodies	C1-unit Interconversion, Eukaryotes Pathway Diagram
Cyanoamino Acid Metabolism Pathway antibodies	Cyanoamino Acid Metabolism Pathway Diagram
Cyanoamino Acid Metabolism Pathway antibodies	Cyanoamino Acid Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram

Diseases associated with SHMT2 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with SHMT2 and Nervous System Diseases
Brain Diseases Antibodies	>1 publications with SHMT2 and Brain Diseases

Organs/Tissues associated with SHMT2 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with SHMT2 and Liver
Adipose Tissue Antibodies	>1 publications with SHMT2 and Adipose Tissue
Ovary Antibodies	>1 publications with SHMT2 and Ovary
Blood Antibodies	>1 publications with SHMT2 and Blood
Connective Tissue Antibodies	>1 publications with SHMT2 and Connective Tissue
Lung Antibodies	>1 publications with SHMT2 and Lung
Brain Antibodies	>1 publications with SHMT2 and Brain