Human SIM2 cDNA Clone Expression Plasmid – Cat# MBS1277438

SIM2 cDNA Clone – Single-Minded Homolog 2 (Drosophila) (Human)

Name: SIM2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277438
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277438

MBS1277438 is a cDNA clone targeting SIM2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIM2, cDNA Clone

Full Product Name

SIM2 cDNA Clone

Product Gene Name

SIM2 cdna clone

Sequence

ATGAAGGAGA AGTCCAAGAA TGCGGCCAAG ACCAGGAGGG AGAAGGAAAA TGGCGAGTTT TACGAGCTTG CCAAGCTGCT CCCGCTGCCG TCGGCCATCA CTTCGCAGCT GGACAAAGCG TCCATCATCC GCCTCACCAC GAGCTACCTG AAGATGCGCG CCGTCTTCCC CGAAGGTTTA GGAGACGCGT GGGGACAGCC GAGCCGCGCC GGGCCCCTGG ACGGCGTCGC CAAGGAGCTG GGATCGCACT TGCTGCAGAC TTTGGATGGA TTTGTTTTTG TGGTAGCATC TGATGGCAAA ATCATGTATA TATCCGAGAC CGCTTCTGTC CATTTAGGCT TATCCCAGGT GGAGCTCACG GGCAACAGTA TTTATGAATA CATCCATCCT TCTGACCACG ATGAGATGAC CGCTGTCCTC ACGGCCCACC AGCCGCTGCA CCACCACCTG CTCCAAGAGT ATGAGATAGA GAGGTCGTTC TTTCTTCGAA TGAAATGTGT CTTGGCGAAA AGGAACGCGG GCCTGACCTG CAGCGGATAC AAGGTCATCC ACTGCAGTGG CTACTTGAAG ATCAGGCAGT ATATGCTGGA CATGTCCCTG TACGACTCCT GCTACCAGAT TGTGGGGCTG GTGGCCGTGG GCCAGTCGCT GCCACCCAGT GCCATCACCG AGATCAAGCT GTACAGTAAC ATGTTCATGT TCAGGGCCAG CCTTGACCTG AAGCTGATAT TCCTGGATTC CAGGGTGACC GAGGTGACGG GGTACGAGCC GCAGGACCTG ATCGAGAAGA CCCTATACCA TCACGTGCAC GGCTGCGACG TGTTCCACCT CCGCTACGCA CACCACCTCC TGTTGGTGAA GGGCCAGGTC ACCACCAAGT ACTACCGGCT GCTGTCCAAG CGGGGCGGCT GGGTGTGGGT GCAGAGCTAC GCCACCGTGG TGCACAACAG CCGCTCGTCC CGGCCCCACT GCATCGTGAG TGTCAATTAT GTACTCACGG AGATTGAATA CAAGGAACTT CAGCTGTCCC TGGAGCAGGT GTCCACTGCC AAGTCCCAGG ACTCCTGGAG GACCGCCTTG TCTACCTCAC AAGAAACTAG GAAATTAGTG AAACCCAAAA ATACCAAGAT GAAGACAAAG CTGAGAACAA ACCCTTACCC CCCACAGCAA TACAGCTCGT TCCAAATGGA CAAACTGGAA TGCGGCCAGC TCGGAAACTG GAGAGCCAGT CCCCCTGCAA GCGCTGCTGC TCCTCCAGAA CTGCAGCCCC ACTCAGAAAG CAGTGACCTT CTGTACACGC CATCCTACAG CCTGCCCTTC TCCTACCATT ACGGACACTT CCCTCTGGAC TCTCACGTCT TCAGCAGCAA AAAGCCAATG TTGCCGGCCA AGTTCGGGCA GCCCCAAGGA TCCCCTTGTG AGGTGGCACG CTTTTTCCTG AGCACACTGC CAGCCAGCGG TGAATGCCAG TGGCATTATG CCAACCCCCT AGTGCCTAGC AGCTCGTCTC CAGCTAAAAA TCCTCCAGAG CCACCGGCGA ACACTGCTAG GCACAGCCTG GTGCCAAGCT ACGAAGGTGG GTCAGGTCTG CTCGTGGGGA AGGTGGGAGG ACTGCGCACG GCCGGGAGCC GAAGCAGCCA TGGCGGTGGG TGGCAGATGG AGACAGAACC CTCACGCTTT GGGCAAACTT GCCCTCTTTC TGCTTCTAAG TAG

Molecular Weight

63,523 Da

OMIM

600892

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SIM2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIM2. It may not necessarily be applicable to this product.

NCBI GI #

115527445

NCBI GeneID

6493

NCBI Accession #

BC110444

UniProt Secondary Accession #

O60766; Q15470; Q15471; Q15472; Q15473; Q16532; Q2TBD8

UniProt Related Accession #

Q14190

NCBI Official Full Name

Homo sapiens single-minded homolog 2 (Drosophila), mRNA

NCBI Official Synonym Full Names

single-minded family bHLH transcription factor 2

NCBI Official Symbol

SIM2

NCBI Official Synonym Symbols

SIM; bHLHe15; HMC13F06; HMC29C01

UniProt Protein Name

Single-minded homolog 2

UniProt Synonym Protein Names

Class E basic helix-loop-helix protein 15; bHLHe15

Protein Family

Single-minded

UniProt Gene Name

SIM2

UniProt Synonym Gene Names

BHLHE15; bHLHe15

UniProt Entry Name

SIM2_HUMAN

NCBI Protein Information

single-minded homolog 2

NCBI Summary for SIM2

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

UniProt Comments for SIM2

SIM2: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: nucleoplasm

Molecular Function: transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter

Research Articles on SIM2

1. In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SIM2 cdna clone

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>27 publications with SIM2 and Congenital Abnormalities
Breast Neoplasms Antibodies	>5 publications with SIM2 and Breast Neoplasms
Intestinal Neoplasms Antibodies	>4 publications with SIM2 and Intestinal Neoplasms
Disease Models, Animal Antibodies	>4 publications with SIM2 and Disease Models, Animal
Respiratory Tract Diseases Antibodies	>2 publications with SIM2 and Respiratory Tract Diseases
Alzheimer Disease Antibodies	>2 publications with SIM2 and Alzheimer Disease
Craniofacial Abnormalities Antibodies	>2 publications with SIM2 and Craniofacial Abnormalities
Kidney Diseases Antibodies	>1 publications with SIM2 and Kidney Diseases
Learning Disorders Antibodies	>1 publications with SIM2 and Learning Disorders
Memory Disorders Antibodies	>1 publications with SIM2 and Memory Disorders

Organs/Tissues associated with SIM2 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>27 publications with SIM2 and Brain
Prostate Antibodies	>10 publications with SIM2 and Prostate
Kidney Antibodies	>9 publications with SIM2 and Kidney
Lung Antibodies	>6 publications with SIM2 and Lung
Bone Antibodies	>5 publications with SIM2 and Bone
Testis Antibodies	>1 publications with SIM2 and Testis