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SMNDC1 cDNA Clone – Survival of Motor Neuron-Related-Splicing Factor 30

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200706

SMNDC1 is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
SMNDC1, cDNA Clone
Full Product Name
SMNDC1
Product Gene Name
SMNDC1 cdna clone
Product Synonym Names
SMNR; SPF30; TDRD16C
Sequence
Nucleotide Sequence: ATGTCAGAGG ATTTAGCAAA GCAGCTGGCA AGCTACAAAG CTCAGCTCCA GCAAGTTGAA GCTGCATTAT CTGGAAATGG AGAAAATGAA GATTTGCTAA AATTGAAGAA AGATTTACAA GAAGTTATAG AACTAACCAA AGACCTTCTG TCAACTCAAC CTTCTGAGAC GCTTGCAAGT TCAGACAGTT TTGCTTCTAC TCAACCTACT CATTCATGGA AAGTAGGAGA CAAGTGTATG GCAGTCTGGA GTGAAGATGG ACAGTGTTAT GAAGCGGAGA TTGAGGAGAT AGATGAAGAA AATGGCACCG CTGCAATCAC CTTTGCTGGT TATGGCAATG CTGAAGTGAC TCCACTGTTG AACCTCAAGC CTGTAGAAGA AGGAAGGAAG GCAAAGGAGG ACAGTGGCAA CAAACCCATG TCAAAAAAAG AAATGATTGC CCAGCAGCGT GAATATAAAA AGAAGAAAGC TTTGAAAAAA GCTCAGAGAA TAAAAGAACT TGAGCAGGAA AGAGAGGACC AGAAAGTGAA ATGGCAACAA TTCAACAACA GAGCCTATTC TAAAAACAAA AAAGGCCAGG TAAAGAGGAG TATTTTTGCT TCACCTGAGA GTGTGACTGG TAAAGTTGGA GTAGGAACCT GTGGAATTGC TGATAAACCT ATGACACAAT ATCAAGATAC CTCTAAATAC AATGTCAGGC ATTTGATGCC TCAATAA

Trans lation Sequence: MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAG YGNAEVTPLL NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
603519
3D Structure
ModBase 3D Structure for O75940
Species
Human
Chromosome Location
10q23
OMIM Reference Number
603519
cDNA Size
717bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for SMNDC1 cdna clone

Apoptosis; Cell Cycle

Other Notes

Small volumes of SMNDC1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMNDC1 purchase

MBS200706 is a cDNA clone targeting SMNDC1.

Additional Details

NCBI/Uniprot data below describe general gene information for SMNDC1. It may not necessarily be applicable to this product.

NCBI GI #
5032113
NCBI GeneID
10285
NCBI Accession #
NP_005862.1
UniProt Primary Accession #
O75940
UniProt Related Accession #
O75940
GenBank Nucleotide #
NM_005871.3
NCBI Official Full Name
survival of motor neuron-related-splicing factor 30
NCBI Official Synonym Full Names
survival motor neuron domain containing 1
NCBI Official Symbol
SMNDC1
NCBI Official Synonym Symbols
SMNR; SPF30; TDRD16C
UniProt Protein Name
Survival of motor neuron-related-splicing factor 30
UniProt Synonym Protein Names
30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1
Protein Family
Survival of motor neuron-related-splicing factor
UniProt Gene Name
SMNDC1
UniProt Synonym Gene Names
SMNR; SPF30
UniProt Entry Name
SPF30_HUMAN
NCBI Protein Information
survival of motor neuron-related-splicing factor 30

NCBI Summary for SMNDC1

This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for SMNDC1

SPF30: Necessary for spliceosome assembly. Overexpression causes apoptosis. Belongs to the SMN family.

Protein type: Spliceosome; RNA processing; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: nucleoplasm; spliceosome; Cajal body; intermediate filament cytoskeleton; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding

Biological Process: RNA splicing, via transesterification reactions; apoptosis; RNA splicing; spliceosome assembly; mRNA processing
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Research Articles on SMNDC1

1. The results show that SMNDC1 mRNA 5'-UTR forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SMNDC1 cdna clone

 Reference Product  PubMed Publications
 SNRPN cdna clone  >2 publications with SMNDC1 and SNRPN
 PRPF3 cdna clone  >1 publications with SMNDC1 and PRPF3

Pathways associated with SMNDC1 cdna clone

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram

Diseases associated with SMNDC1 cdna clone

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >1 publications with SMNDC1 and Carcinoma, Hepatocellular

Organs/Tissues associated with SMNDC1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with SMNDC1 and Heart
 Muscle Antibodies  >1 publications with SMNDC1 and Muscle
 Pancreas Antibodies  >1 publications with SMNDC1 and Pancreas
 Liver Antibodies  >1 publications with SMNDC1 and Liver
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