Human SS18L1 cDNA Clone Expression Plasmid – Cat# MBS1266247

SS18L1 cDNA Clone – Synovial Sarcoma Translocation Gene on Chromosome 18-Like 1 (Human)

Name: SS18L1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266247
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266247

MBS1266247 is a cDNA clone targeting SS18L1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SS18L1, cDNA Clone

Full Product Name

SS18L1 cDNA Clone

Product Gene Name

SS18L1 cdna clone

Sequence

atgcagagtc taagcacaga ggccagatac gtcccaagag tcccccagca cagagatcag ataagtccca ggagtcccca gcacggaggc cagatatgtc ccaggagtcc cctgcacaga ggccagatat gtcccaggag tcccccagca cggaggtacc agcagatcct gcaccggaac ctggtatacc tggccacgat cgcagactcc aaccagaaca tgcagtccct gcttcctgcc ccgcccacgc agaacatgaa cctgggccct ggagccctga ctcagagcgg ctccagccag ggcctgcact ctcagggcag cctgagtgac gccatcagca cgggcctgcc accctcctcc ctcctgcagg gccagattgg caacgggccg agccacgtgt ccatgcagca gacggcgcct aacacgctgc ccaccacctc catgagcatc tctgggcccg gctacagcca cgcgggaccc gcctcgcagg gcgtccccat gcaggggcaa ggcaccatcg gcaactacgt gtctcggacc aacatcaaca tgcagtccaa cccagtctcc atgatgcagc agcaggcggc cacgtcgcac tacagctcgg cgcagggcgg cagccagcac taccagggcc agtcgtccat cgccatgatg gggcagggca gccaggggag cagcatgatg gggcagcggc ccatggcgcc ctaccggccc tcccagcaag gctcttccca gcagtacctg ggccaggagg agtactatgg cgagcagtac agccacagcc agggcgccgc ggagcccatg ggccagcagt actaccccga cggccatggc gattacgcct accagcagtc atcctacacg gagcagagct acgaccggtc cttcgaggag tccacgcagc actactatga ggggggaaac tcccagtaca gccagcagca ggccgggtac cagcagggtg ccgcgcagca gcagacgtac tcccagcagc agtaccccag ccagcagagc taccccgggc agcagcaggg ctacgggtct gcccagggag ccccgtcaca gtaccccggc taccagcaag gccaaggcca gcagtacgga agctaccgag caccgcagac agcgccgtct gcccagcagc agcggcccta cggctatgaa cagggccagt atggaaatta ccagcagtaa

Molecular Weight

43,408 Da

OMIM

606472

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SS18L1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SS18L1. It may not necessarily be applicable to this product.

NCBI GI #

46362566

NCBI GeneID

26039

NCBI Accession #

BC068993

UniProt Secondary Accession #

Q5JXJ3; Q6MZV9; Q6NTH3; Q6XYD9; Q8NE69; Q9BR55; Q9H4K6; A6NNE3; A8K620; B3KWR8; E1P5H7

UniProt Related Accession #

O75177

NCBI Official Full Name

Homo sapiens synovial sarcoma translocation gene on chromosome 18-like 1, mRNA

NCBI Official Synonym Full Names

SS18L1, nBAF chromatin remodeling complex subunit

NCBI Official Symbol

SS18L1

NCBI Official Synonym Symbols

CREST; LP2261

UniProt Protein Name

Calcium-responsive transactivator

UniProt Synonym Protein Names

SS18-like protein 1; SYT homolog 1

Protein Family

Calcium-responsive transactivator

UniProt Gene Name

SS18L1

UniProt Synonym Gene Names

CREST; KIAA0693

UniProt Entry Name

CREST_HUMAN

NCBI Protein Information

calcium-responsive transactivator

NCBI Summary for SS18L1

This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

UniProt Comments for SS18L1

SS18L1: Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the SS18 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: kinetochore; nucleus

Molecular Function: protein binding

Biological Process: positive regulation of transcription, DNA-dependent

Research Articles on SS18L1

1. calcium-responsive transactivator and certain other amyotrophic lateral sclerosis-linked proteins share several features implicated in amyotrophic lateral sclerosis pathogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SS18L1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with SS18L1 and Neoplasms
Cardiovascular Diseases Antibodies	>1 publications with SS18L1 and Cardiovascular Diseases
Skin Diseases Antibodies	>1 publications with SS18L1 and Skin Diseases
Drug Toxicity Antibodies	>1 publications with SS18L1 and Drug Toxicity

Organs/Tissues associated with SS18L1 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with SS18L1 and Brain
Blood Antibodies	>1 publications with SS18L1 and Blood