Human STAM cDNA Clone Expression Plasmid – Cat# MBS1273747

STAM cDNA Clone – Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (Human)

Name: STAM cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273747
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273747

MBS1273747 is a cDNA clone targeting STAM. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STAM, cDNA Clone

Full Product Name

STAM cDNA Clone

Product Gene Name

STAM cdna clone

Sequence

atgcctcttt ttgccaccaa tcccttcgat caggatgttg agaaagcaac cagcgagatg aatactgctg aggactgggg cctcattttg gatatctgtg ataaagttgg tcagtctcgc actggaccta aggattgtct tcggtctatt atgagaagag tgaaccacaa agatcctcac gttgctatgc aggctttgac tcttctagga gcatgtgtat caaactgtgg caaaattttt catttagaag tatgttcaag agattttgct agtgaagtaa gcaacgtatt aaataagggt catcctaaag tatgtgaaaa attaaaggct cttatggttg aatggacaga tgaatttaag aatgatccac agcttagtct aatatcagca atgattaaga accttaagga acaaggagtt acgttcccag ctattggctc tcaggctgca gaacaagcaa aagcaagccc agctcttgta gccaaggatc ctggtactgt ggctaacaaa aaagaagaag aagatttagc aaaagccatt gagttgtctc tcaaggaaca aaggcagcag tcaaccaccc tttccacttt gtatccaagc acatccagtc tcttaactaa ccaccaacat gaaggccgaa aagttcgtgc tatatatgac tttgaagctg ctgaagacaa tgaacttact tttaaagctg gagaaattat tacagttctt gatgacagtg atcctaactg gtggaaaggt gaaacccatc aaggcatagg gttatttcct tctaattttg tgactgcata tctcactgct gaaccagaaa tgattaaaac agagaagaag acggtacaat ttagtgatga tgttcaggta gagacaatag aaccagagcc ggaaccagcc tttattgatg aagataaaat ggaccagttg ctacagatgc tgcaaagtac agaccccagt gatgatcagc cagacctacc agagctgctt catcttgaag caatgtgtca ccagatggga cctctcattg atgaaaagct ggaagatatt gatagaaaac attcagaact ctcagaactt aatgtgaaag tgatggaggc cctttcctta tataccaagt taatgaacga agatccgatg tattccatgt atgcaaagtt acagaatcag ccaggcagtg gtcccaccat ccgcaaaccc agcccttcct ag

Molecular Weight

44,972 Da

OMIM

601899

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STAM cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAM. It may not necessarily be applicable to this product.

NCBI GI #

34192153

NCBI GeneID

8027

NCBI Accession #

BC030586

UniProt Secondary Accession #

Q8N6D9; B0YJ99; D3DRU5

UniProt Related Accession #

Q92783

NCBI Official Full Name

Homo sapiens signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, mRNA

NCBI Official Synonym Full Names

signal transducing adaptor molecule

NCBI Official Symbol

STAM

NCBI Official Synonym Symbols

STAM1; STAM-1

UniProt Protein Name

Signal transducing adapter molecule 1

Protein Family

Signal transducing adapter molecule

UniProt Gene Name

STAM

UniProt Synonym Gene Names

STAM1; STAM-1

UniProt Entry Name

STAM1_HUMAN

NCBI Protein Information

signal transducing adapter molecule 1

NCBI Summary for STAM

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

UniProt Comments for STAM

STAM1: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p14-p13

Cellular Component: cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: autophagy; endosome transport; negative regulation of epidermal growth factor receptor signaling pathway; signal transduction

Research Articles on STAM

1. The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with STAM cdna clone

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
EGFR Downregulation Pathway antibodies	EGFR Downregulation Pathway Diagram
ESCRT-0 Complex Pathway antibodies	ESCRT-0 Complex Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies	Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
IL-4 Signaling Pathway antibodies	IL-4 Signaling Pathway Diagram
IL-7 Signaling Pathway antibodies	IL-7 Signaling Pathway Diagram
IL2-mediated Signaling Events Pathway antibodies	IL2-mediated Signaling Events Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with STAM cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>483 publications with STAM and Nervous System Diseases
Brain Diseases Antibodies	>335 publications with STAM and Brain Diseases
Neoplasms Antibodies	>188 publications with STAM and Neoplasms
Pain Antibodies	>104 publications with STAM and Pain
Immune System Diseases Antibodies	>92 publications with STAM and Immune System Diseases
Lung Diseases Antibodies	>61 publications with STAM and Lung Diseases
Neurobehavioral Manifestations Antibodies	>37 publications with STAM and Neurobehavioral Manifestations
Hemorrhage Antibodies	>36 publications with STAM and Hemorrhage
Cognition Disorders Antibodies	>31 publications with STAM and Cognition Disorders
Kidney Diseases Antibodies	>31 publications with STAM and Kidney Diseases

Organs/Tissues associated with STAM cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>314 publications with STAM and Brain
Blood Antibodies	>200 publications with STAM and Blood
Heart Antibodies	>111 publications with STAM and Heart
Vascular Antibodies	>111 publications with STAM and Vascular
Nerve Antibodies	>95 publications with STAM and Nerve
Lung Antibodies	>59 publications with STAM and Lung
Bone Antibodies	>49 publications with STAM and Bone
Skin Antibodies	>35 publications with STAM and Skin
Spinal Cord Antibodies	>33 publications with STAM and Spinal Cord
Kidney Antibodies	>30 publications with STAM and Kidney