Human STAT1 cDNA Clone Expression Plasmid – Cat# MBS1272199

STAT1 cDNA Clone – Signal Transducer and Activator of Transcription 1, 91kDa (Human)

Name: STAT1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272199
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272199

MBS1272199 is a cDNA clone targeting STAT1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STAT1, cDNA Clone

Full Product Name

STAT1 cDNA Clone

Product Gene Name

STAT1 cdna clone

Sequence

atgtctcagt ggtacgaact tcagcagctt gactcaaaat tcctggagca ggttcaccag ctttatgatg acagttttcc catggaaatc agacagtacc tggcacagtg gttagaaaag caagactggg agcacgctgc caatgatgtt tcatttgcca ccatccgttt tcatgacctc ctgtcacagc tggatgatca atatagtcgc ttttctttgg agaataactt cttgctacag cataacataa ggaaaagcaa gcgtaatctt caggataatt ttcaggaaga cccaatccag atgtctatga tcatttacag ctgtctgaag gaagaaagga aaattctgga aaacgcccag agatttaatc aggctcagtc ggggaatatt cagagcacag tgatgttaga caaacagaaa gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta tgtgtataga gcatgaaatc aagagcctgg aagatttaca agatgaatat gacttcaaat gcaaaacctt gcagaacaga gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac aagaacagct gttactcaag aagatgtatt taatgcttga caataagaga aaggaagtag ttcacaaaat aatagagttg ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg atgaactagt ggagtggaag cggagacagc agagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct gctgttactt tccctgacat cattcgcaat tacaaagtca tggctgctga gaatattcct gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga tatatcaaga ctgagttgat ttctgtgtct gaagtgtaa

Molecular Weight

83,043 Da

OMIM

600555

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STAT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT1. It may not necessarily be applicable to this product.

NCBI GI #

33877045

NCBI GeneID

6772

NCBI Accession #

BC002704

UniProt Secondary Accession #

Q53S88; Q53XW4; Q68D00; Q9UDL5; A8K989; B2RCA0; D2KFR8; D3DPI7

UniProt Related Accession #

P42224

NCBI Official Full Name

Homo sapiens signal transducer and activator of transcription 1, 91kDa, mRNA

NCBI Official Synonym Full Names

signal transducer and activator of transcription 1

NCBI Official Symbol

STAT1

NCBI Official Synonym Symbols

CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91

UniProt Protein Name

Signal transducer and activator of transcription 1-alpha/beta

UniProt Synonym Protein Names

Transcription factor ISGF-3 components p91/p84

Protein Family

Signal transducer and activator of transcription

UniProt Gene Name

STAT1

UniProt Entry Name

STAT1_HUMAN

NCBI Protein Information

signal transducer and activator of transcription 1-alpha/beta

NCBI Summary for STAT1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for STAT1

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: axon; cell-cell adherens junction; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: double-stranded DNA binding; enzyme binding; identical protein binding; nuclear hormone receptor binding; protein binding; protein homodimerization activity; transcription factor activity; tumor necrosis factor receptor binding

Biological Process: apoptosis; blood circulation; endothelial cell migration; JAK-STAT cascade; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to cAMP; response to cytokine stimulus; response to peptide hormone stimulus; tumor necrosis factor-mediated signaling pathway

Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c

Research Articles on STAT1

1. Interferonstimulated gene factor 3 complex, which consists of STAT1, STAT2 and IRF9, is required for the induction of SAMHD1 expression by IFN-alpha in SMMC-7721 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with STAT1 cdna clone

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with STAT1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1011 publications with STAT1 and Neoplasms
Inflammation Antibodies	>673 publications with STAT1 and Inflammation
Necrosis Antibodies	>478 publications with STAT1 and Necrosis
Liver Diseases Antibodies	>236 publications with STAT1 and Liver Diseases
Nervous System Diseases Antibodies	>232 publications with STAT1 and Nervous System Diseases
Cardiovascular Diseases Antibodies	>185 publications with STAT1 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>165 publications with STAT1 and Adenocarcinoma
Lung Diseases Antibodies	>145 publications with STAT1 and Lung Diseases
Neoplasms, Experimental Antibodies	>120 publications with STAT1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>107 publications with STAT1 and Breast Neoplasms

Organs/Tissues associated with STAT1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1323 publications with STAT1 and Blood
Liver Antibodies	>386 publications with STAT1 and Liver
Bone Antibodies	>284 publications with STAT1 and Bone
Lung Antibodies	>279 publications with STAT1 and Lung
Brain Antibodies	>249 publications with STAT1 and Brain
Vascular Antibodies	>232 publications with STAT1 and Vascular
Muscle Antibodies	>205 publications with STAT1 and Muscle
Bone Marrow Antibodies	>197 publications with STAT1 and Bone Marrow
Skin Antibodies	>171 publications with STAT1 and Skin
Kidney Antibodies	>148 publications with STAT1 and Kidney