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STAT6 cDNA Clone – Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267903

MBS1267903 is a cDNA clone targeting STAT6. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAT6, cDNA Clone
Full Product Name
STAT6 cDNA Clone
Product Gene Name
STAT6 cdna clone
Sequence
atgtctctgt ggggtctggt ctccaagatg cccccagaaa aagtgcagcg gctctatgtc gactttcccc aacacctgcg gcatcttctg ggtgactggc tggagagcca gccctgggag ttcctggtcg gctccgacgc cttctgctgc aacttggcta gtgccctact ttcagacact gtccagcacc ttcaggcctc ggtgggagag cagggggagg ggagcaccat cttgcaacac atcagcaccc ttgagagcat atatcagagg gaccccctga agctggtggc cactttcaga caaatacttc aaggagagaa aaaagctgtt atggaacagt tccgccactt gccaatgcct ttccactgga agcaggaaga actcaagttt aagacaggct tgcggaggct gcagcaccga gtaggggaga tccaccttct ccgagaagcc ctgcagaagg gggctgaggc tggccaagtg tctctgcaca gcttgataga aactcctgct aatgggactg ggccaagtga ggccctggcc atgctactgc aggagaccac tggagagcta gaggcagcca aagccctagt gctgaagagg atccagattt ggaaacggca gcagcagctg gcagggaatg gcgcaccgtt tgaggagagc ctggccccac tccaggagag gtgtgaaagc ctggtggaca tttattccca gctacagcag gaggtagggg cggctggtgg ggagcttgag cccaagaccc gggcatcgct gactggccgg ctggatgaag tcctgagaac cctcgtcacc agttgcttcc tggtggagaa gcagcccccc caggtactga agactcagac caagttccag gctggagttc gattcctgtt gggcttgagg ttcctggggg ccccagccaa gcctccgctg gtcagggccg acatggtgac agagaagcag gcgcgggagc tgagtgtgcc tcagggtcct ggggctggag cagaaagcac tggagaaatc atcaacaaca ctgtgccctt ggagaacagc attcctggga actgctgctc tgccctgttc aagaacctgc ttctcaagaa gatcaagcgg tgtgagcgga agggcactga gtctgtcaca gaggagaagt gcgctgtgct cttctctgcc agcttcacac ttggccccgg caaactcccc atccagctcc aggccctgtc tctgcccctg gtggtcatcg tccatggcaa ccaagacaac aatgccaaag ccactatcct gtgggacaat gccttctctg agatggaccg cgtgcccttt gtggtggctg agcgggtgcc ctgggagaag atgtgtgaaa ctctgaacct gaagttcatg gctgaggtgg ggaccaaccg ggggctgctc ccagagcact tcctcttcct ggcccagaag atcttcaatg acaacagcct cagtatggag gccttccagc accgttctgt gtcctggtcg cagttcaaca aggagatcct gctgggccgt ggcttcacct tttggcagtg gtttgatggt gtcctggacc tcaccaaacg ctgtctccgg agctactggt ctgaccggct gatcattggc ttcatcagca aacagtacgt tactagcctt cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc atcaccattg cccatgtcat ccggggccag gatggctctc cacagataga gaacatccag ccattctctg ccaaagacct gtccattcgc tcactggggg accgaatccg ggatcttgct cagctcaaaa atctctatcc caagaagccc aaggatgagg ctttccggag ccactacaag cctgaacaga tgggtaagga tggcaggggt tatgtcccag ctaccatcaa gatgaccgtg gaaagggacc aaccacttcc taccccagag ctccagatgc ctaccatggt gccttcttat gaccttggaa tggcccctga ttcctccatg agcatgcagc ttggcccaga tatggtgccc caggtgtacc caccacactc tcactccatc cccccgtatc aaggcctctc cccagaagaa tcagtcaacg tgttgtcagc cttccaggag cctcacctgc agatgccccc cagcctgggc cagatgagcc tgccctttga ccagcctcac ccccagggcc tgctgccgtg ccagcctcag gagcatgctg tgtccagccc tgaccccctg ctctgctcag atgtgaccat ggtggaagac agctgcctga gccagccagt gacagcgttt cctcagggca cttggattgg tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg gtga
Molecular Weight
81,748 Da
OMIM
601512
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STAT6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT6. It may not necessarily be applicable to this product.

NCBI GI #
49904291
NCBI GeneID
6778
NCBI Accession #
BC075852
UniProt Secondary Accession #
Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9
UniProt Related Accession #
P42226
NCBI Official Full Name
Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced, mRNA
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6
NCBI Official Symbol
STAT6
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
STAT6
UniProt Entry Name
STAT6_HUMAN
NCBI Protein Information
signal transducer and activator of transcription 6

NCBI Summary for STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for STAT6

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: identical protein binding; protein binding; protein phosphatase binding

Biological Process: positive regulation of interferon type I production; regulation of transcription from RNA polymerase II promoter; signal transduction
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Research Articles on STAT6

1. These results suggest that STAT6 plays an important role in regulating Sp1 and BCL6 through STAT2 to exert the anti-proliferative effects of type I IFN.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with STAT6 cdna clone

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with STAT6 cdna clone

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >364 publications with STAT6 and Inflammation
 Lung Diseases Antibodies  >244 publications with STAT6 and Lung Diseases
 Neoplasms Antibodies  >206 publications with STAT6 and Neoplasms
 Necrosis Antibodies  >138 publications with STAT6 and Necrosis
 Nervous System Diseases Antibodies  >59 publications with STAT6 and Nervous System Diseases
 Dermatitis, Atopic Antibodies  >53 publications with STAT6 and Dermatitis, Atopic
 Cardiovascular Diseases Antibodies  >45 publications with STAT6 and Cardiovascular Diseases
 Liver Diseases Antibodies  >44 publications with STAT6 and Liver Diseases
 Hyperplasia Antibodies  >39 publications with STAT6 and Hyperplasia
 Neoplasms, Experimental Antibodies  >38 publications with STAT6 and Neoplasms, Experimental

Organs/Tissues associated with STAT6 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >972 publications with STAT6 and Blood
 Lung Antibodies  >268 publications with STAT6 and Lung
 Bone Antibodies  >107 publications with STAT6 and Bone
 Spleen Antibodies  >97 publications with STAT6 and Spleen
 Intestine Antibodies  >91 publications with STAT6 and Intestine
 Bone Marrow Antibodies  >91 publications with STAT6 and Bone Marrow
 Muscle Antibodies  >90 publications with STAT6 and Muscle
 Liver Antibodies  >88 publications with STAT6 and Liver
 Skin Antibodies  >77 publications with STAT6 and Skin
 Lymph Node Antibodies  >67 publications with STAT6 and Lymph Node
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