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SYTL2 cDNA Clone – Synaptotagmin-Like 2 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265776

MBS1265776 is a cDNA clone targeting SYTL2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SYTL2, cDNA Clone
Full Product Name
SYTL2 cDNA Clone
Product Gene Name
SYTL2 cdna clone
Sequence
atgagcaagt ctgttccagc atttctccaa gatgagagtg atgacagaga aacagataca gcatcagaaa gcagttacca gctcagcaga cacaagaaga gcccgagctc tttaaccaat cttagcagct cctctggcat gacgtccttg tcttctgtga gtggcagtgt gatgagtgtt tatagtggag actttggcaa tctggaagtt aaaggaaata ttcagtttgc aattgaatat gtggagtcac tgaaggagtt gcatgttttt gtggcccagt gtaaggactt agcagcagcg gatgtaaaaa aacagcgttc agacccatat gtaaaggcct atttgctacc agacaaaggc aaaatgggca agaagaaaac actcgtagtg aagaaaacct tgaatcctgt gtataacgaa atactgcggt ataaaattga aaaacaaatc ttaaagacac agaaattgaa cctgtccatt tggcatcggg atacatttaa gcgcaatagt ttcctagggg aggtggaact tgatttggaa acatgggact gggataacaa acagaataaa caattgagat ggtaccctct gaagcggaag acagcaccag ttgcccttga agcagaaaac agaggtgaaa tgaaactagc tctccagtat gtcccagagc cagtccctgg taaaaagctt cctacaactg gagaagtgca catctgggtg aaggaatgcc ttgatctacc actgctaagg ggaagtcatc taaattcttt tgttaaatgt accatccttc cagatacaag taggaaaagt cgccagaaga caagagctgt agggaaaacc accaacccta tcttcaacca cactatggtg tatgatgggt tcaggcctga agatctgatg gaagcctgtg tagagcttac tgtctgggac cattacaaat taaccaacca atttttggga ggtcttcgta ttggctttgg aacaggtaaa agttatggga ctgaagtgga ctggatggac tctacttcag aggaagttgc tctctgggag aagatggtaa actcccccaa tacttggatt gaagcaacac tgcctctcag aatgcttttg attgccaaga tttccaaatg a
Molecular Weight
84,651 Da
OMIM
612880
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SYTL2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SYTL2. It may not necessarily be applicable to this product.

NCBI GI #
34784984
NCBI GeneID
54843
NCBI Accession #
BC015540
UniProt Secondary Accession #
Q2YDA7; Q6TV07; Q6ZN59; Q6ZVC5; B3KRS3; B4DJT5; B4DKW3; B4DQ26; B7SA85; B7ZLX6; B7ZLX7
UniProt Related Accession #
Q9HCH5
NCBI Official Full Name
Homo sapiens synaptotagmin-like 2, mRNA
NCBI Official Synonym Full Names
synaptotagmin like 2
NCBI Official Symbol
SYTL2
NCBI Official Synonym Symbols
EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
UniProt Protein Name
Synaptotagmin-like protein 2
UniProt Synonym Protein Names
Breast cancer-associated antigen SGA-72M; Exophilin-4
Protein Family
Synaptotagmin-like protein
UniProt Gene Name
SYTL2
UniProt Synonym Gene Names
KIAA1597; SGA72M; SLP2; SLP2A
UniProt Entry Name
SYTL2_HUMAN
NCBI Protein Information
synaptotagmin-like protein 2

NCBI Summary for SYTL2

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
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UniProt Comments for SYTL2

SYTL2: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Motility/polarity/chemotaxis; GAPs, Rab; GAPs; Lipid-binding

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: cytoplasm; extrinsic to plasma membrane; melanosome; membrane; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; neurexin binding; phosphatase binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; exocytosis; regulation of calcium ion-dependent exocytosis; vesicle docking during exocytosis; vesicle fusion; vesicle-mediated transport
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Research Articles on SYTL2

1. SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SYTL2 cdna clone

 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram

Diseases associated with SYTL2 cdna clone

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >1 publications with SYTL2 and Carcinoma
 Neoplasms Antibodies  >1 publications with SYTL2 and Neoplasms
 Drug Toxicity Antibodies  >1 publications with SYTL2 and Drug Toxicity
 Urinary Bladder Neoplasms Antibodies  >1 publications with SYTL2 and Urinary Bladder Neoplasms
 Inflammation Antibodies  >1 publications with SYTL2 and Inflammation

Organs/Tissues associated with SYTL2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with SYTL2 and Muscle
 Brain Antibodies  >3 publications with SYTL2 and Brain
 Uncharacterized Tissue Antibodies  >2 publications with SYTL2 and Uncharacterized Tissue
 Stomach Antibodies  >1 publications with SYTL2 and Stomach
 Pancreas Antibodies  >1 publications with SYTL2 and Pancreas
 Bladder Antibodies  >1 publications with SYTL2 and Bladder
 Kidney Antibodies  >1 publications with SYTL2 and Kidney
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