Human TBCD cDNA Clone Expression Plasmid – Cat# MBS1278683

TBCD cDNA Clone – Tubulin Folding Cofactor D (Human)

Name: TBCD cDNA Clone; Tubulin Folding Cofactor D; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1278683
Price: 845 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278683

MBS1278683 is a cDNA clone targeting TBCD. More details

$845 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TBCD, cDNA Clone

Full Product Name

TBCD cDNA Clone

Product Gene Name

TBCD cdna clone

Sequence

atggccctga gcgacgaacc ggccgcgggt ggccccgagg aggaggcgga ggacgagaca ctggcctttg gcgcggcgct ggaagcgttc ggcgagagcg cggagacccg ggcgctgctg ggccgcctgc gggaggtgca cggcggcggc gcggagcgcg aggtggccct ggagcggttc cgcgtaataa tggacaaata ccaggagcag cctcatctgt tggacccgca ccttgaatgg atgatgaact tgttgttgga catagtgcaa gatcagacat ctccagcttc ccttgtacat ctggctttta aatttcttta catcatcacc aaggttcgag gctataaaac atttcttcgt ttatttcctc atgaagttgc cgatgtagag cctgttttag atttggtcac aattcagaat cccaaggacc atgaagcttg ggaaacccgc tacatgcttt tgctctggct ctccgtgacc tgcctgatcc cttttgattt ttctcgcctt gacgggaacc tcctcaccca gcctgggcaa gcacgaatgt ccataatgga ccgtattctc caaatagcag agtcctactt gattgtcagt gacaaggccc gagatgcagc tgctgtcctt gtgtccagat ttatcacacg tcctgatgtc aagcaaagca agatggctga gttcctggac tggagcctgt gcaatctggc ccgttcctcc ttccagacca tgcagggggt catcaccatg gatgggacgc tgcaggccct ggcacaaata tttaaacatg gaaaacgtga agactgtttg ccctatgctg ccactgtcct caggtgcctc gatggctgca gactccctga gagcaaccag accctgctgc ggaagctggg ggtgaagctt gtgcagcgac tggggctgac attcctgaag ccgaaggtgg cagcatggag gtaccagcgt ggctgccgat ctttggctgc aaatctgcag ctcctcactc agggtcagag tgagcagaag ccactcatcc tgaccgaaga tgacgacgaa gatgacgacg tcccagaggg ggtggagcgt gtgatagagc agctgctggt cgggctgaag gacaaggaca cggtcgtgcg gtggtctgca gccaagggca tcggtaggat ggctggcagg cttcccagag ccctggcgga tgatgtggtc gggtctgtgc tggactgctt cagtttccag gagactgaca aggcgtggca tgggggatgt ctggcgctgg cagagctggg caggagaggc ctgttgctgc cgtctcgact cgtggatgtt gtcgccgtga tcctgaaggc gctgacctac gacgagaagc ggggtgcctg cagcgtgggc accaacgtca gggacgccgc ctgctacgtg tgctgggcct tcgcgcgtgc ctatgagcct caggagctga agccctttgt gactgcaatc tcgagtgcac tggtgattgc tgcggtgttt gaccgagaca taaactgcag aagagcagcc tctgccgcct tccaggagaa tgtggggaga cagggcactt tccctcatgg tattgatatt ttgaccacag ctgactattt tgccgtcggt aacagatcca actgtttcct ggttataagt gtgtttattg ccggctttcc tgagtacacg cagccaatga tagaccacct ggttaccatg aagatcagcc actgggatgg ggtcatccga gagttggctg cgagggcgct gcacaacctg gcccagcagg cacccgagtt cagcgccacg caagtcttcc cgaggctgct gtccatgaca ctgagtccag atcttcacat gaggcatggg tcgattctcg cctgcgcaga agttgcttac gccttgtaca aacttgcagc ccaagagaac aggcccgtca cggaccatct ggacgagcag gcagtgcagg gcctgaagca gattcaccag cagctctatg atcgtcagtt atacaggggt ctgggaggac agctcatgag acaagcagtg tgtgttttaa tagaaaagtt gtcactttcc aaaatgccct ttagaggtga caccgtaatt gatggttggc aatggctgat aaatgactcg ctgtggcttc tcgttggcct tgggcgccct tccaggcttc cttctgaaag gccggctcca gcaggttctc acaggtttaa gagcagttac ccacacttcc cccgaggacg taagttttgc tga

Molecular Weight

84,263 Da

OMIM

604649

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TBCD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TBCD. It may not necessarily be applicable to this product.

NCBI GI #

13623514

NCBI GeneID

6904

NCBI Accession #

BC006364

UniProt Secondary Accession #

O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9UF82; Q9UG46; Q9Y2J3

UniProt Related Accession #

Q9BTW9

NCBI Official Full Name

Homo sapiens tubulin folding cofactor D, mRNA

NCBI Official Synonym Full Names

tubulin folding cofactor D

NCBI Official Symbol

TBCD

NCBI Official Synonym Symbols

tfcD; SSD-1

UniProt Protein Name

Tubulin-specific chaperone D

UniProt Synonym Protein Names

Beta-tubulin cofactor D; tfcD; SSD-1; Tubulin-folding cofactor D

Protein Family

Tubulin-specific chaperone

UniProt Gene Name

TBCD

UniProt Synonym Gene Names

KIAA0988; SSD1; TFCD; tfcD

UniProt Entry Name

TBCD_HUMAN

NCBI Protein Information

tubulin-specific chaperone D

NCBI Summary for TBCD

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

UniProt Comments for TBCD

TBCD: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Belongs to the TBCD family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: adherens junction; lateral plasma membrane; microtubule; tight junction

Molecular Function: beta-tubulin binding; chaperone binding; GTPase activator activity; protein binding

Biological Process: negative regulation of microtubule polymerization; post-chaperonin tubulin folding pathway; protein folding; tubulin folding

Research Articles on TBCD

1. genetic polymorphism is associated with bone mineral accretion in children with asthma receiving intermittent oral corticosteroids

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TBCD cdna clone

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-chaperonin Tubulin Folding Pathway antibodies	Post-chaperonin Tubulin Folding Pathway Diagram
Protein Folding Pathway antibodies	Protein Folding Pathway Diagram

Diseases associated with TBCD cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with TBCD and Nervous System Diseases
Neoplasms Antibodies	>2 publications with TBCD and Neoplasms
Lymphoma Antibodies	>1 publications with TBCD and Lymphoma
Breast Neoplasms Antibodies	>1 publications with TBCD and Breast Neoplasms
Abnormalities, Multiple Antibodies	>1 publications with TBCD and Abnormalities, Multiple
Congenital Abnormalities Antibodies	>1 publications with TBCD and Congenital Abnormalities

Organs/Tissues associated with TBCD cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>3 publications with TBCD and Blood
Eye Antibodies	>3 publications with TBCD and Eye
Nerve Antibodies	>1 publications with TBCD and Nerve
Bone Antibodies	>1 publications with TBCD and Bone
Connective Tissue Antibodies	>1 publications with TBCD and Connective Tissue
Brain Antibodies	>1 publications with TBCD and Brain