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TCHP cDNA Clone – Trichoplein, Keratin Filament Binding (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274271

MBS1274271 is a cDNA clone targeting TCHP. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TCHP, cDNA Clone
Full Product Name
TCHP cDNA Clone
Product Gene Name
TCHP cdna clone
Sequence
atggcgctcc cgacgctgcc gtcctactgg tgcagccagc agcgcctgaa tcagcagcta gcacgacagc gagagcagga ggcccggctt cggcagcagt gggagcagaa cagccgttac ttcaggatgt ctgacatctg cagctccaaa caggcagaat ggagctctaa aacctcctac cagcggagca tgcatgccta tcagcgggag aagatgaagg aggagaagag gaggagtctg gaggcccgac gggaaaagct caggcagctc atgcaggagg agcaggacct gctggccaga gaactggagg agctgaggct gagcatgaac ttgcaggaaa gaagaatccg ggagcagcac gggaagctga aatcagccaa agaagagcag aggaaactga ttgctgaaca acttttgtac gaacactgga aaaagaacaa cccgaaactt cgagagatgg agctggacct tcaccagaag catgtcgtaa actcttggga aatgcagaaa gaagaaaaaa aacagcaaga agccaccgca gagcaagaga acaaacggta tgaaaatgaa tatgaaaggg cccgaaggga ggcgctagaa aggatgaaag ctgaagagga gaggaggcag ctggaggaca agctccaggc cgaggcactg ctgcaacaga tggaggagct gaagctgaag gaggtggagg cgaccaaact aaagaaggag caggagaatc tgttgaagca gcggtgggag ctagagaggc tggaggaaga gcgaaagcag atggaagcct tccggcagaa ggcagagctg gggcgtttct tgagacatca gtataacgct caactcagca gacgcacaca gcagatccaa gaggagctgg aggcagacag gcggatcctg caggccctcc tcgagaagga ggacgagagc cagcgcctcc acctggccag gcgggagcag gtcatggccg atgtggcctg gatgaagcag gccattgagg agcagctgca gctggagcgg gcgcgggagg cagagctgca gatgctgctg agggaggagg ccaaggagat gtgggaaaag agagaggcag agtgggcccg agagcgcagc gcacgggaca gactgatgag cgaggttctg acagggagac aacagcaaat acaagagaag attgagcaga accgacgggc acaagaggaa tccctgaaac acagggagca acttattcga aatcttgagg aggtgagaga gttggctcgt cgcgagaaag aggagagtga aaagctgaaa tcggccagga agcaggagct ggaagcccag gttgcagagc gccggctgca ggcatgggaa gcagaccagc aggaggagga ggaagaggag gaggcccggc gggtcgagca gctctcagat gccctgctgc agcaggaggc ggagactatg gctgagcagg gctaccggcc taagccttac ggacatccaa aaattgcttg gaactga
Molecular Weight
61,072 Da
OMIM
612654
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TCHP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TCHP. It may not necessarily be applicable to this product.

NCBI GI #
13279121
NCBI GeneID
84260
NCBI Accession #
BC004285
UniProt Secondary Accession #
Q8NAG0
UniProt Related Accession #
Q9BT92
NCBI Official Full Name
Homo sapiens trichoplein, keratin filament binding, mRNA
NCBI Official Synonym Full Names
trichoplein keratin filament binding
NCBI Official Symbol
TCHP
NCBI Official Synonym Symbols
TpMs
UniProt Protein Name
Trichoplein keratin filament-binding protein
UniProt Synonym Protein Names
Mitochondrial protein with oncostatic activity; Mitostatin; Tumor suppressor protein
Protein Family
Trichoplein keratin filament-binding protein
UniProt Gene Name
TCHP
UniProt Synonym Gene Names
Protein TCHP; Mitostatin
UniProt Entry Name
TCHP_HUMAN
NCBI Protein Information
trichoplein keratin filament-binding protein

UniProt Comments for TCHP

TCHP: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Belongs to the TCHP family.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: apical cortex; centrosome; cytoplasm; keratin filament; mitochondrion; plasma membrane

Molecular Function: protein binding

Biological Process: apoptosis; negative regulation of cell growth
Show more

Research Articles on TCHP

1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with TCHP cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with TCHP and Neoplasms
 Heart Diseases Antibodies  >2 publications with TCHP and Heart Diseases
 Carcinoma Antibodies  >2 publications with TCHP and Carcinoma
 Heart Defects, Congenital Antibodies  >1 publications with TCHP and Heart Defects, Congenital
 Congenital Abnormalities Antibodies  >1 publications with TCHP and Congenital Abnormalities

Organs/Tissues associated with TCHP cdna clone

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >1 publications with TCHP and Lymph Node
 Blood Antibodies  >1 publications with TCHP and Blood
 Bone Antibodies  >1 publications with TCHP and Bone
 Parathyroid Antibodies  >1 publications with TCHP and Parathyroid
 Eye Antibodies  >1 publications with TCHP and Eye
 Intestine Antibodies  >1 publications with TCHP and Intestine
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