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THG1L cDNA Clone – Trna-Histidine Guanylyltransferase 1-Like (S. Cerevisiae) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274464

MBS1274464 is a cDNA clone targeting THG1L. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
THG1L, cDNA Clone
Full Product Name
THG1L cDNA Clone
Product Gene Name
THG1L cdna clone
Sequence
atggcaaaaa gcaagttcga gtacgtgagg gacttcgagg ctgacgacac ctgcctggca cactgctggg tggtagtgcg gctggacggc cggaatttcc atcggtttgc tgagaagcac aactttgcaa aacccaatga cagccgtgct ctccagctga tgaccaaatg tgcgcagact gtgatggaag aactagagga tattgtgatc gcgtatggac agagtgatga gtacagcttt gtgttcaagc ggaaaaccaa ttggtttaaa agaagagcca gtaagttcat gactcacgtg gcctcccagt ttgcctccag ctatgtgttt tattggcggg attactttga ggaccagccc cttctgtatc ccccaggctt tgacggaaga gtcgtggtgt atcccagcaa ccagacttta aaggactacc tcagctggcg acaagcagat tgtcacatca ataatcttta taatacagtt ttctgggcac ttatacaaca atctggacta acaccagtac aagcccaagg gagattacag ggaactcttg cagcagacaa gaatgagatt ttgttttctg aattcaacat caactataat aatgagctgc cgatgtatag gaaagggact gtgttgatat ggcagaaggt ggatgaagtg atgacaaaag aaattaagct gccaacagaa atggaaggaa aaaagatggc agtgacccgg accaggacaa agccagtgcc cttgcactgc gatatcatcg gggatgcttt ctggaaggaa catccagaga ttctagatga agacagctga
Molecular Weight
34,831 Da
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of THG1L cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for THG1L. It may not necessarily be applicable to this product.

NCBI GI #
33989067
NCBI GeneID
54974
NCBI Accession #
BC001523
UniProt Secondary Accession #
Q53G12; Q7L5R3; Q9H0S2; D3DQJ5
UniProt Related Accession #
Q9NWX6
NCBI Official Full Name
Homo sapiens tRNA-histidine guanylyltransferase 1-like (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
tRNA-histidine guanylyltransferase 1 like
NCBI Official Symbol
THG1L
NCBI Official Synonym Symbols
ICF45; IHG-1; hTHG1
UniProt Protein Name
Probable tRNA(His) guanylyltransferase
UniProt Synonym Protein Names
Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferase
UniProt Gene Name
THG1L
UniProt Synonym Gene Names
ICF45
UniProt Entry Name
THG1_HUMAN
NCBI Protein Information
probable tRNA(His) guanylyltransferase

NCBI Summary for THG1L

The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
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UniProt Comments for THG1L

ICF45: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Belongs to the tRNA(His) guanylyltransferase family.

Protein type: Mitochondrial; EC 2.7.7.79; Cell cycle regulation; Transferase

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: cytosol; mitochondrion

Molecular Function: ATP binding; GTP binding; identical protein binding; magnesium ion binding; nucleotidyltransferase activity; protein binding; tRNA binding; tRNA guanylyltransferase activity

Biological Process: protein homotetramerization; tRNA modification; tRNA processing
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Research Articles on THG1L

1. The high-resolution crystal structure of human Thg1 reveals remarkable structural similarity between canonical DNA/RNA polymerases and eukaryotic Thg1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with THG1L cdna clone

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Modification In The Nucleus And Cytosol Pathway antibodies  TRNA Modification In The Nucleus And Cytosol Pathway Diagram
 TRNA Processing Pathway antibodies  TRNA Processing Pathway Diagram

Organs/Tissues associated with THG1L cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with THG1L and Brain
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