• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TPM3 cDNA Clone – Tropomyosin Alpha-3 Chain Isoform Tpm3.1cy

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200746

TPM3 encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in… More details

$245 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TPM3, cDNA Clone
Full Product Name
TPM3
Product Gene Name
TPM3 cdna clone
Product Synonym Names
CAPM1; CFTD; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK
Sequence
Nucleotide Sequence: ATGGCTGGGA TCACCACCAT CGAGGCGGTG AAGCGCAAGA TCCAGGTTCT GCAGCAGCAG GCAGATGATG CAGAGGAGCG AGCTGAGCGC CTCCAGCGAG AAGTTGAGGG AGAAAGGCGG GCCCGGGAAC AGGCTGAGGC TGAGGTGGCC TCCTTGAACC GTAGGATCCA GCTGGTTGAA GAAGAGCTGG ACCGTGCTCA GGAGCGCCTG GCCACTGCCC TGCAAAAGCT GGAAGAAGCT GAAAAAGCTG CTGATGAGAG TGAGAGAGGT ATGAAGGTTA TTGAAAACCG GGCCTTAAAA GATGAAGAAA AGATGGAACT CCAGGAAATC CAACTCAAAG AAGCTAAGCA CATTGCAGAA GAGGCAGATA GGAAGTATGA AGAGGTGGCT CGTAAGTTGG TGATCATTGA AGGAGACTTG GAACGCACAG AGGAACGAGC TGAGCTGGCA GAGTCCCGTT GCCGAGAGAT GGATGAGCAG ATTAGACTGA TGGACCAGAA CCTGAAGTGT CTGAGTGCTG CTGAAGAAAA GTACTCTCAA AAAGAAGATA AATATGAGGA AGAAATCAAG ATTCTTACTG ATAAACTCAA GGAGGCAGAG ACCCGTGCTG AGTTTGCTGA GAGATCGGTA GCCAAGCTGG AAAAGACAAT TGATGACCTG GAAGATAAAC TGAAATGCAC CAAAGAGGAG CACCTCTGTA CACAAAGGAT GCTGGACCAG ACCCTGCTTG ACCTGAATGA GATGTAG

Trans lation Sequence: MAGITTIEAV KRKIQVLQQQ ADDAEERAER LQREVEGERR AREQAEAEVA SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRALK DEEKMELQEI QLKEAKHIAE EADRKYEEVA RKLVIIEGDL ERTEERAELA ESRCREMDEQ IRLMDQNLKC LSAAEEKYSQ KEDKYEEEIK ILTDKLKEAE TRAEFAERSV AKLEKTIDDL EDKLKCTKEE HLCTQRMLDQ TLLDLNEM
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
phenotype 609284
3D Structure
ModBase 3D Structure for P06753
Species
Human
Chromosome Location
1q21.2
OMIM Reference Number
191030
cDNA Size
747bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted Nde I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for TPM3 cdna clone

Cytoskeleton; Signal Transduction

Other Notes

Small volumes of TPM3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPM3 purchase

MBS200746 is a cDNA clone targeting TPM3.

Additional Details

NCBI/Uniprot data below describe general gene information for TPM3. It may not necessarily be applicable to this product.

NCBI GI #
24119203
NCBI GeneID
7170
NCBI Accession #
NP_705935.1
UniProt Primary Accession #
P06753
UniProt Related Accession #
P06753
GenBank Nucleotide #
NM_153649.3
NCBI Official Full Name
tropomyosin alpha-3 chain isoform Tpm3.1cy
NCBI Official Synonym Full Names
tropomyosin 3
NCBI Official Symbol
TPM3
NCBI Official Synonym Symbols
TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPM3nu; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5
UniProt Protein Name
Tropomyosin alpha-3 chain
UniProt Synonym Protein Names
Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5
Protein Family
Tropomyosin
UniProt Gene Name
TPM3
UniProt Synonym Gene Names
hTM5
UniProt Entry Name
TPM3_HUMAN
NCBI Protein Information
tropomyosin alpha-3 chain

NCBI Summary for TPM3

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Show more

UniProt Comments for TPM3

TPM3: a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described.

Protein type: Contractile; Cytoskeletal; Oncoprotein; Actin-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: cortical cytoskeleton; filamentous actin; cytoskeleton; growth cone; stress fiber; podosome; cytosol; muscle thin filament tropomyosin; cleavage furrow

Molecular Function: actin binding

Biological Process: muscle contraction; cell motility; muscle filament sliding

Disease: Nemaline Myopathy 1; Myopathy, Congenital, With Fiber-type Disproportion
Show more

Research Articles on TPM3

1. the effect of the E173A, R90P, E150A, and A155T myopathy-causing substitutions in gamma-tropomyosin (Tpm3.12) on the position of tropomyosin in thin filaments and the conformational state of actin monomers and myosin heads at different stages of the ATPase cycle, was examined.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TPM3 cdna clone

 Reference Product  PubMed Publications
 TMOD1 cdna clone  >54 publications with TPM3 and TMOD1
 ACTA1 cdna clone  >30 publications with TPM3 and ACTA1
 TNNT2 cdna clone  >25 publications with TPM3 and TNNT2
 NEB cdna clone  >18 publications with TPM3 and NEB
 TNNI3 cdna clone  >18 publications with TPM3 and TNNI3
 TNNT1 cdna clone  >13 publications with TPM3 and TNNT1
 MYL3 cdna clone  >13 publications with TPM3 and MYL3
 TNNT3 cdna clone  >9 publications with TPM3 and TNNT3
 VCL cdna clone  >2 publications with TPM3 and VCL
 TNNI1 cdna clone  >1 publications with TPM3 and TNNI1

Pathways associated with TPM3 cdna clone

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with TPM3 cdna clone

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >479 publications with TPM3 and Cardiovascular Diseases
 Carcinoma Antibodies  >152 publications with TPM3 and Carcinoma
 Disease Models, Animal Antibodies  >147 publications with TPM3 and Disease Models, Animal
 Hypertrophy Antibodies  >140 publications with TPM3 and Hypertrophy
 Inflammation Antibodies  >80 publications with TPM3 and Inflammation
 Lung Diseases Antibodies  >69 publications with TPM3 and Lung Diseases
 Adenocarcinoma Antibodies  >60 publications with TPM3 and Adenocarcinoma
 Nemaline myopathy 1 Antibodies  >49 publications with TPM3 and Nemaline myopathy 1
 Fibrosis Antibodies  >48 publications with TPM3 and Fibrosis
 Neoplasm Metastasis Antibodies  >46 publications with TPM3 and Neoplasm Metastasis

Organs/Tissues associated with TPM3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3676 publications with TPM3 and Muscle
 Heart Antibodies  >906 publications with TPM3 and Heart
 Brain Antibodies  >589 publications with TPM3 and Brain
 Blood Antibodies  >564 publications with TPM3 and Blood
 Nerve Antibodies  >350 publications with TPM3 and Nerve
 Embryonic Tissue Antibodies  >296 publications with TPM3 and Embryonic Tissue
 Vascular Antibodies  >246 publications with TPM3 and Vascular
 Lung Antibodies  >166 publications with TPM3 and Lung
 Skin Antibodies  >120 publications with TPM3 and Skin
 Liver Antibodies  >116 publications with TPM3 and Liver
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000