Human TRPM8 cDNA Clone Expression Plasmid – Cat# MBS1274453

TRPM8 cDNA Clone – Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (Human)

Name: TRPM8 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274453
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274453

MBS1274453 is a cDNA clone targeting TRPM8. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRPM8, cDNA Clone

Full Product Name

TRPM8 cDNA Clone

Product Gene Name

TRPM8 cdna clone

Sequence

atgcaggcca tcaatacctc catcaaaaat aaaattcctt gtgtggtggt ggaaggctcg ggccagatcg ctgatgtgat cgctagcctg gtggaggtgg aggatgccct gacatcttct gccgtcaagg agaagctggt gcgcttttta ccccgcacgg tgtcccggct gcctgaggag gagactgaga gttggatcaa atggctcaaa gaaattctcg aatgttctca cctattaaca gttattaaaa tggaagaagc tggggatgaa attgtgagca atgccatctc ctacgctcta tacaaagcct tcagcaccag tgagcaagac aaggataact ggaatgggca gctgaagctt ctgctggagt ggaaccagct ggacttagcc aatgatgaga ttttcaccaa tgaccgccga tgggagtctg ctgaccttca agaagtcatg tttacggctc tcataaagga cagacccaag tttgtccgcc tctttctgga gaatggcttg aacctacgga agtttctcac ccatgatgtc ctcactgaac tcttctccaa ccacttcagc acgcttgtgt accggaatct gcagatcgcc aagaattcct ataatgatgc cctcctcacg tttgtctgga aactggttgc gaacttccga agaggcttcc ggaaggaaga cagaaatggc cgggacgaga tggacataga actccacgac gtgtctccta ttactcggca ccccctgcaa gctctcttca tctgggccat tcttcagaat aagaaggaac tctccaaagt catttgggag cagaccaggg gctgcactct ggcagccctg ggagccagca agcttctgaa gactctggcc aaagtgaaga acgacatcaa tgctgctggg gagtccgagg agctggctaa tgagtacgag acccgggctg ttgagctgtt cactgagtgt tacagcagcg atgaagactt ggcagaacag ctgctggtct attcctgtga agcttggggt ggaagcaact gtctggagct ggcggtggag gccacagacc agcatttcat cgcccagcct ggggtccagt ggtacgtaaa tggggtgaat tattttactg acctgtggaa tgtgatggac acgctggggc ttttttactt catagcagga attgtatttc ggctccactc ttctaataaa agctctttgt attctggacg agtcattttc tgtctggact acattatttt cactctaaga ttgatccaca tttttactgt aagcagaaac ttaggaccca agattataat gctgcagagg atgctgatcg atgtgttctt cttcctgttc ctctttgcgg tgtggatggt ggcctttggc gtggccaggc aagggatcct taggcagaat gagcagcgct ggaggtggat attccgttcg gtcatctacg agccctacct ggccatgttc ggccaggtgc ccagtgacgt ggatggtacc acgtatgact ttgcccactg caccttcact gggaatgagt ccaagccact gtgtgtggag ctggatgagc acaacctgcc ccggttcccc gagtggatca ccatccccct ggtgtgcatc tacatgttat ccaccaacat cctgctggtc aacctgctgg tcgccatgtt tggctacacg gtgggcaccg tccaggagaa caatgaccag gtctggaagt tccagaggta cttcctggtg caggagtact gcagccgcct caatatcccc ttccccttca tcgtcttcgc ttacttctac atggtggtga agaagtgctt caagtgttgc tgcaaggaga aaaacatgga gtcttctgtc tgctgtttca aaaatgaaga caatgagact ctggcatggg agggtgtcat gaaggaaaac taccttgtca agatcaacac aaaagccaac gacacctcag aggaaatgag gcatcgattt agacaactgg atacaaagct taatgatctc aagggtcttc tgaaagagat tgctaataaa atcaaataa

Molecular Weight

79,096 Da

OMIM

606678

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TRPM8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPM8. It may not necessarily be applicable to this product.

NCBI GI #

116496784

NCBI GeneID

79054

NCBI Accession #

BC126342

UniProt Secondary Accession #

Q3YFM7; Q6QNH9; Q8TAC3; Q8TDX8; Q9BVK1; A0AVG2

UniProt Related Accession #

Q7Z2W7

NCBI Official Full Name

Homo sapiens transient receptor potential cation channel, subfamily M, member 8, mRNA

NCBI Official Synonym Full Names

transient receptor potential cation channel subfamily M member 8

NCBI Official Symbol

TRPM8

NCBI Official Synonym Symbols

TRPP8; LTRPC6

UniProt Protein Name

Transient receptor potential cation channel subfamily M member 8

UniProt Synonym Protein Names

Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8

Protein Family

Transient receptor potential cation channel subfamily

UniProt Gene Name

TRPM8

UniProt Synonym Gene Names

LTRPC6; TRPP8; LTrpC-6; LTrpC6; Trp-p8

UniProt Entry Name

TRPM8_HUMAN

NCBI Protein Information

transient receptor potential cation channel subfamily M member 8

UniProt Comments for TRPM8

TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: plasma membrane

Molecular Function: calcium channel activity; protein binding

Research Articles on TRPM8

1. Study used a combination of molecular modeling and experimental techniques to examine the structure of the TRPM8 transmembrane and pore helix region including the conducting conformation of the selectivity filter

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with TRPM8 cdna clone

Disease Name	Pubmed Publications
Pain Antibodies	>166 publications with TRPM8 and Pain
Neoplasms Antibodies	>57 publications with TRPM8 and Neoplasms
Hyperalgesia Antibodies	>37 publications with TRPM8 and Hyperalgesia
Inflammation Antibodies	>34 publications with TRPM8 and Inflammation
Drug Hypersensitivity Antibodies	>20 publications with TRPM8 and Drug Hypersensitivity
Urinary Bladder Diseases Antibodies	>14 publications with TRPM8 and Urinary Bladder Diseases
Neuralgia Antibodies	>12 publications with TRPM8 and Neuralgia
Necrosis Antibodies	>5 publications with TRPM8 and Necrosis
Migraine without Aura Antibodies	>5 publications with TRPM8 and Migraine without Aura
Migraine Disorders Antibodies	>5 publications with TRPM8 and Migraine Disorders

Organs/Tissues associated with TRPM8 cdna clone

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>61 publications with TRPM8 and Skin
Prostate Antibodies	>58 publications with TRPM8 and Prostate
Brain Antibodies	>50 publications with TRPM8 and Brain
Vascular Antibodies	>17 publications with TRPM8 and Vascular
Lung Antibodies	>13 publications with TRPM8 and Lung
Liver Antibodies	>9 publications with TRPM8 and Liver
Intestine Antibodies	>8 publications with TRPM8 and Intestine
Eye Antibodies	>8 publications with TRPM8 and Eye
Testis Antibodies	>5 publications with TRPM8 and Testis