Human TRPV4 cDNA Clone Expression Plasmid – Cat# MBS1271174

TRPV4 cDNA Clone – Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (Human)

Name: TRPV4 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1271174
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271174

MBS1271174 is a cDNA clone targeting TRPV4. More details

$970 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRPV4, cDNA Clone

Full Product Name

TRPV4 cDNA Clone

Product Gene Name

TRPV4 cdna clone

Sequence

atggcggatt ccagcgaagg cccccgcgcg gggcccgggg aggtggctga gctccccggg gatgagagtg gcaccccagg cggggaggct tttcctctct cctccctggc caatctgttt gagggggagg atggctccct ttcgccctca ccggctgatg ccagtcgccc tgctggccca ggcgatgggc gaccaaatct gcgcatgaag ttccagggcg ccttccgcaa gggggtgccc aaccccatcg atctgctgga gtccacccta tatgagtcct cggtggtgcc tgggcccaag aaagcaccca tggactcact gtttgactac ggcacctatc gtcaccactc cagtgacaac aagaggtgga ggaagaagat catagagaag cagccacaga gccccaaagc ccctgcccct cagccgcccc ccatcctcaa agtcttcaac cggcctatcc tctttgacat cgtgtcccgg ggctccactg ctgacctgga cgggctgctc ccattcttgc tgacccacaa gaaacgccta actgatgagg agtttcgaga gccatctacg gggaagacct gcctgcccaa ggccttgctg aacctgagca atggccgcaa cgacaccatc cctgtgctgc tggacatcgc ggagcgcacc ggcaacatgc gggagttcat taactcgccc ttccgtgaca tctactatcg aggtcagaca gccctgcaca tcgccattga gcgtcgctgc aaacactacg tggaacttct cgtggcccag ggagctgatg tccacgccca ggcccgtggg cgcttcttcc agcccaagga tgaggggggc tacttctact ttggggagct gcccctgtcg ctggctgcct gcaccaacca gccccacatt gtcaactacc tgacggagaa cccccacaag aaggcggaca tgcggcgcca ggactcgcga ggcaacacag tgctgcatgc gctggtggcc attgctgaca acacccgtga gaacaccaag tttgttacca agatgtacga cctgctgctg ctcaagtgtg cccgcctctt ccccgacagc aacctggagg ccgtgctcaa caacgacggc ctctcgcccc tcatgatggc tgccaagacg ggcaagattg ggatctttca gcacatcatc cggcgggagg tgacggatga ggacacacgg cacctgtccc gcaagttcaa ggactgggcc tatgggccag tgtattcctc gctttatgac ctctcctccc tggacacgtg tggggaagag gcctccgtgc tggagatcct ggtgtacaac agcaagattg agaaccgcca cgagatgctg gctgtggagc ccatcaatga actgctgcgg gacaagtggc gcaagttcgg ggccgtctcc ttctacatca acgtggtctc ctacctgtgt gccatggtca tcttcactct caccgcctac taccagccgc tggagggcac accgccgtac ccttaccgca ccacggtgga ctacctgcgg ctggctggcg aggtcattac gctcttcact ggggtcctgt tcttcttcac caacatcaaa gacttgttca tgaagaaatg ccctggagtg aattctctct tcattgatgg ctccttccag ctgctctact tcatctactc tgtcctggtg atcgtctcag cagccctcta cctggcaggg atcgaggcct acctggccgt gatggtcttt gccctggtcc tgggctggat gaatgccctt tacttcaccc gtgggctgaa gctgacgggg acctatagca tcatgatcca gaagattctc ttcaaggacc ttttccgatt cctgctcgtc tacttgctct tcatgatcgg ctacgcttca gccctggtct ccctcctgaa cccgtgtgcc aacatgaagg tgtgcaatga ggaccagacc aactgcacag tgcccactta cccctcgtgc cgtgacagcg agaccttcag caccttcctc ctggacctgt ttaagctgac catcggcatg ggcgacctgg agatgctgag cagcaccaag taccccgtgg tcttcatcat cctgctggtg acctacatca tcctcacctt tgtgctgctc ctcaacatgc tcattgccct catgggcgag acagtgggcc aggtctccaa ggagagcaag cacatctgga agctgcagtg ggccaccacc atcctggaca ttgagcgctc cttccccgta ttcctgagga aggccttccg ctctggggag atggtcaccg tgggcaagag ctcggacggc actcctgacc gcaggtggtg cttcagggtg gatgaggtga actggtctca ctggaaccag aacttgggca tcatcaacga ggacccgggc aagaatgaga cctaccagta ttatggcttc tcgcataccg tgggccgcct ccgcagggat cgctggtcct cggtggtacc ccgcgtggtg gaactgaaca agaactcgaa cccggacgag gtggtggtgc ctctggacag catggggaac ccccgctgcg atggccacca gcagggttac ccccgcaagt ggaggactga tgacgccccg ctctag

Molecular Weight

85,884 Da

OMIM

113500

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TRPV4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPV4. It may not necessarily be applicable to this product.

NCBI GI #

109659095

NCBI GeneID

59341

NCBI Accession #

BC117426

UniProt Secondary Accession #

Q17R79; Q2Y122; Q2Y123; Q2Y124; Q86YZ6; Q8NDY7; Q8NG64; Q96Q92; Q96RS7; Q9HBC0; B7ZKQ6

UniProt Related Accession #

Q9HBA0

NCBI Official Full Name

Homo sapiens transient receptor potential cation channel, subfamily V, member 4, mRNA

NCBI Official Synonym Full Names

transient receptor potential cation channel subfamily V member 4

NCBI Official Symbol

TRPV4

NCBI Official Synonym Symbols

SMAL; VRL2; BCYM3; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1

UniProt Protein Name

Transient receptor potential cation channel subfamily V member 4

UniProt Synonym Protein Names

Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC

Protein Family

Transient receptor potential cation channel subfamily

UniProt Gene Name

TRPV4

UniProt Synonym Gene Names

VRL2; VROAC; TrpV4; OTRPC4; TRP12; VRL-2; VR-OAC

UniProt Entry Name

TRPV4_HUMAN

NCBI Protein Information

transient receptor potential cation channel subfamily V member 4

NCBI Summary for TRPV4

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

UniProt Comments for TRPV4

TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: adherens junction; cilium; cortical actin cytoskeleton; cytoplasmic microtubule; filopodium; focal adhesion; growth cone; integral to plasma membrane; lamellipodium; plasma membrane

Molecular Function: actin binding; actin filament binding; alpha-tubulin binding; beta-tubulin binding; calcium channel activity; calmodulin binding; cation channel activity; microtubule binding; protein binding; protein kinase binding; protein kinase C binding; SH2 domain binding; stretch-activated, cation-selective, calcium channel activity

Biological Process: actin cytoskeleton reorganization; actin filament organization; calcium ion transport; cell volume homeostasis; cellular calcium ion homeostasis; cortical microtubule organization and biogenesis; elevation of cytosolic calcium ion concentration; intercellular junction assembly; microtubule polymerization; multicellular organismal water homeostasis; osmosensory signaling pathway; positive regulation of microtubule depolymerization; positive regulation of vascular permeability; response to mechanical stimulus

Disease: Brachyolmia Type 3; Digital Arthropathy-brachydactyly, Familial; Hereditary Motor And Sensory Neuropathy, Type Iic; Metatropic Dysplasia; Parastremmatic Dwarfism; Scapuloperoneal Spinal Muscular Atrophy; Sodium Serum Level Quantitative Trait Locus 1; Spinal Muscular Atrophy, Distal, Congenital Nonprogressive; Spondyloepiphyseal Dysplasia, Maroteaux Type; Spondylometaphyseal Dysplasia, Kozlowski Type

Research Articles on TRPV4

1. Identify TRPV4 as novel regulator of neutrophil activation and suggest contributions of both parenchymal and neutrophilic TRPV4 in the pathophysiology of acute lung injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with TRPV4 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>110 publications with TRPV4 and Nervous System Diseases
Pain Antibodies	>92 publications with TRPV4 and Pain
Inflammation Antibodies	>50 publications with TRPV4 and Inflammation
Hyperalgesia Antibodies	>42 publications with TRPV4 and Hyperalgesia
Hypertension Antibodies	>37 publications with TRPV4 and Hypertension
Cardiovascular Diseases Antibodies	>32 publications with TRPV4 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>28 publications with TRPV4 and Disease Models, Animal
Bone Diseases Antibodies	>25 publications with TRPV4 and Bone Diseases
Muscular Atrophy, Spinal Antibodies	>18 publications with TRPV4 and Muscular Atrophy, Spinal
SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY Antibodies	>18 publications with TRPV4 and SCAPULOPERONEAL SPINAL MUSCULAR ATROPHY

Organs/Tissues associated with TRPV4 cdna clone

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>66 publications with TRPV4 and Kidney
Brain Antibodies	>61 publications with TRPV4 and Brain
Lung Antibodies	>44 publications with TRPV4 and Lung
Skin Antibodies	>41 publications with TRPV4 and Skin
Bone Antibodies	>35 publications with TRPV4 and Bone
Heart Antibodies	>30 publications with TRPV4 and Heart
Liver Antibodies	>16 publications with TRPV4 and Liver
Intestine Antibodies	>15 publications with TRPV4 and Intestine
Mouth Antibodies	>8 publications with TRPV4 and Mouth
Connective Tissue Antibodies	>8 publications with TRPV4 and Connective Tissue