Human TTK cDNA Clone Expression Plasmid – Cat# MBS1266270

TTK cDNA Clone – TTK Protein Kinase (Human)

Name: TTK cDNA Clone; TTK Protein Kinase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266270
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266270

MBS1266270 is a cDNA clone targeting TTK. More details

$630 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TTK, cDNA Clone

Full Product Name

TTK cDNA Clone

Product Gene Name

TTK cdna clone

Sequence

atggaatccg aggatttaag tggcagagaa ttgacaattg attccataat gaacaaagtg agagacatta aaaataagtt taaaaatgaa gaccttactg atgaactaag cttgaataaa atttctgctg atactacaga taactcggga actgttaacc aaattatgat gatggcaaac aacccagagg actggttgag tttgttgctc aaactagaga aaaacagtgt tccgctaagt gatgctcttt taaataaatt gattggtcgt tacagtcaag caattgaagc gcttccccca gataaatatg gccaaaatga gagttttgct agaattcaag tgagatttgc tgaattaaaa gctattcaag agccagatga tgcacgtgac tactttcaaa tggccagagc aaactgcaag aaatttgctt ttgttcatat atcttttgca caatttgaac tgtcacaagg taatgtcaaa aaaagtaaac aacttcttca aaaagctgta gaacgtggag cagtaccact agaaatgctg gaaattgccc tgcggaattt aaacctccaa aaaaagcagc tgctttcaga ggaggaaaag aagaatttat cagcatctac ggtattaact gcccaagaat cattttccgg ttcacttggg catttacaga ataggaacaa cagttgtgat tccagaggac agactactaa agccaggttt ttatatggag agaacatgcc accacaagat gcagaaatag gttaccggaa ttcattgaga caaactaaca aaactaaaca gtcatgccca tttggaagag tcccagttaa ccttctaaat agcccagatt gtgatgtgaa gacagatgat tcagttgtac cttgttttat gaaaagacaa acctctagat cagaatgccg agatttggtt gtgcctggat ctaaaccaag tggaaatgat tcctgtgaat taagaaattt aaagtctgtt caaaatagtc atttcaagga acctctggtg tcagatgaaa agagttctga acttattatt actgattcaa taaccctgaa gaataaaacg gaatcaagtc ttctagctaa attagaagaa actaaagagt atcaagaacc agaggttcca gagagtaacc agaaacagtg gcaatctaag agaaagtcag agtgtattaa ccagaatcct gctgcatctt caaatcactg gcagattccg gagttagccc gaaaagttaa tacagagcag aaacatacca cttttgagca acctgtcttt tcagtttcaa aacagtcacc accaatatca acatctaaat ggtttgaccc aaaatctatt tgtaagacac caagcagcaa taccttggat gattacatga gctgttttag aactccagtt gtaaagaatg actttccacc tgcttgtcag ttgtcaacac cttatggcca acctgcctgt ttccagcagc aacagcatca aatacttgcc actccacttc aaaatttaca ggttttagca tcttcttcag caaatgaatg catttcggtt aaaggaagaa tttattccat tttaaagcag ataggaagtg gaggttcaag caaggtattt caggtgttaa atgaaaagaa acagatatat gctataaaat atgtgaactt agaagaagca gataaccaaa ctcttgatag ttaccggaac gaaatagctt atttgaataa actacaacaa cacagtgata agatcatccg actttatgat tatgaaatca cggaccagta catctacatg gtaatggagt gtggaaatat tgatcttaat agttggctta aaaagaaaaa atccattgat ccatgggaac gcaagagtta ctggaaaaat atgttagagg cagttcacac aatccatcaa catggcattg ttcacagtga tcttaaacca gctaactttc tgatagttga tggaatgcta aagctaattg attttgggat tgcaaaccaa atgcaaccag atacaacaag tgttgttaaa gattctcagg ttggcacagt taattatatg ccaccagaag caatcaaaga tatgtcttcc tccagagaga atgggaaatc taagtcaaag ataagcccca aaagtgatgt ttggtcctta ggatgtattt tgtactatat gacttacggg aaaacaccat ttcagcagat aattaatcag atttctaaat tacatgccat aattgatcct aatcatgaaa ttgaatttcc cgatattcca gagaaagatc ttcaagatgt gttaaagtgt tgtttaaaaa gggacccaaa acagaggata tccattcctg agctcctggc tcatccctat gttcaaattc aaactcatcc agttaaccaa atggccaagg gaaccactga agaaatgaaa tatgttctgg gccaacttgt tggtctgaat tctcctaact ccattttgaa agctgctaaa actttatatg aacactatag tggtggtgaa agtcataatt cttcatcctc caagactttt gaaaaaaaaa ggggaaaaaa atga

Molecular Weight

96,944 Da

OMIM

604092

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TTK cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TTK. It may not necessarily be applicable to this product.

NCBI GI #

33990673

NCBI GeneID

7272

NCBI Accession #

BC000633

UniProt Secondary Accession #

Q15272; Q5TCS0; Q9BW51; Q9NTM0; A8K8U5; B2RDW2; E1P543

UniProt Related Accession #

P33981

NCBI Official Full Name

Homo sapiens TTK protein kinase, mRNA

NCBI Official Synonym Full Names

TTK protein kinase

NCBI Official Symbol

TTK

NCBI Official Synonym Symbols

ESK; PYT; CT96; MPH1; MPS1; MPS1L1

UniProt Protein Name

Dual specificity protein kinase TTK

UniProt Synonym Protein Names

Phosphotyrosine picked threonine-protein kinase; PYT

Protein Family

Dual specificity protein kinase

UniProt Gene Name

TTK

UniProt Synonym Gene Names

MPS1; MPS1L1; PYT

UniProt Entry Name

TTK_HUMAN

NCBI Protein Information

dual specificity protein kinase TTK

NCBI Summary for TTK

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

UniProt Comments for TTK

TTK: a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint.

Protein type: Cancer Testis Antigen (CTA); Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Protein kinase, Other; Other group; TTK family

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: cytoplasm; membrane; spindle

Molecular Function: protein binding

Biological Process: mitotic cell cycle spindle assembly checkpoint; mitotic spindle organization and biogenesis; positive regulation of cell proliferation; spindle organization and biogenesis

Research Articles on TTK

1. TTK contributes to hepatocellular carcinoma tumorigenesis via promoting cell proliferation and migration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TTK cdna clone

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram

Diseases associated with TTK cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>56 publications with TTK and Neoplasms
Carcinoma Antibodies	>19 publications with TTK and Carcinoma
Brain Diseases Antibodies	>12 publications with TTK and Brain Diseases
Nervous System Diseases Antibodies	>12 publications with TTK and Nervous System Diseases
Disease Models, Animal Antibodies	>9 publications with TTK and Disease Models, Animal
Drug Toxicity Antibodies	>8 publications with TTK and Drug Toxicity
Breast Neoplasms Antibodies	>7 publications with TTK and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>5 publications with TTK and Carcinoma, Squamous Cell
Cell Transformation, Neoplastic Antibodies	>5 publications with TTK and Cell Transformation, Neoplastic
Colonic Neoplasms Antibodies	>4 publications with TTK and Colonic Neoplasms

Organs/Tissues associated with TTK cdna clone

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>35 publications with TTK and Eye
Brain Antibodies	>28 publications with TTK and Brain
Blood Antibodies	>22 publications with TTK and Blood
Embryonic Tissue Antibodies	>13 publications with TTK and Embryonic Tissue
Muscle Antibodies	>10 publications with TTK and Muscle
Testis Antibodies	>10 publications with TTK and Testis
Heart Antibodies	>9 publications with TTK and Heart
Bone Antibodies	>6 publications with TTK and Bone
Vascular Antibodies	>6 publications with TTK and Vascular
Liver Antibodies	>5 publications with TTK and Liver