Human USP14 cDNA Clone Expression Plasmid – Cat# MBS1268991

USP14 cDNA Clone – Ubiquitin Specific Peptidase 14 (Trna-Guanine Transglycosylase) (Human)

Name: USP14 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268991
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268991

MBS1268991 is a cDNA clone targeting USP14. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

USP14, cDNA Clone

Full Product Name

USP14 cDNA Clone

Product Gene Name

USP14 cdna clone

Sequence

atgccgctct actccgttac tgtaaaatgg ggaaaggaga aatttgaagg tgtagaattg aatacagatg aacctccaat ggtattcaag gctcagctgt ttgcgttgac tggagtccag cctgccagac agaaagttat ggtgaaagga ggaacgctaa aggatgatga ttggggaaac atcaaaataa aaaatggaat gactctacta atgatggggt cagcagatgc tcttccagaa gaaccctcag ccaaaactgt cttcgtagaa gacatgacag aagaacagtt agcatctgct atggagttac catgtggatt gacaaacctt ggtaacactt gttacatgaa tgccacagtt cagtgtattc gttctgtgcc tgaactcaaa gatgccctta aaaggtatgc aggtgccttg agagcttcag gggaaatggc ttcagcgcag tatattactg cagcccttag agatttgttt gattccatgg ataaaacttc ttccagtatt ccacctatta ttctactgca gtttttgcac atggctttcc cacagtttgc cgagaaaggt gaacaaggac agtatcttca acaggatgct aatgaatgtt ggatacaaat gatgcgagta ttgcaacaga aattggaagc aatagaggat gattctgtta aagagacaga ctcctcatct gcatcggcag cgacaccttc taaaaagaaa agtttaatcg atcagttctt cggtgttgag tttgaaacta ccatgaaatg tacagaatct gaagaagaag aagtcaccaa aggaaaggaa aatcaacttc agcttagctg ttttatcaat caggaagtca agtatctttt tacaggactt aaattgcgac ttcaggaaga aatcaccaaa cagtctccaa cgttgcaaag aaatgccttg tatatcaaat cttccaagat cagccggctg cctgcttact tgaccattca gatggttcga tttttttata aagagaagga atctgtgaat gccaaagttc ttaaggatgt taaatttcct cttatgttgg atatgtatga actgtgtaca ccagaacttc aagagaaaat ggtgtctttt cgatccaaat tcaaggatct agaagataaa aaagtgaatc agcagccaaa tacaagtgac aaaaagagta gtccccagaa agaagttaag tatgaaccct tttcttttgc tgatgatatt ggctccaata attgtggata ctatgactta caagcagtac taacacacca gggaaggtct agttcttcag gtcattatgt atcatgggtg aaaaggaaac aagatgaatg gattaagttt gatgatgaca aagtcagcat cgtaacacca gaagatatct tacggctttc tggtggtgga gactggcata tcgcttacgt tctactctat gggcctcgca gagttgaaat aatggaagag gaaagtgaac agtaa

Molecular Weight

54,770 Da

OMIM

607274

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of USP14 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for USP14. It may not necessarily be applicable to this product.

NCBI GI #

13097695

NCBI GeneID

9097

NCBI Accession #

BC003556

UniProt Secondary Accession #

Q53XY5; B7Z4N8; J3QRZ5

UniProt Related Accession #

P54578

NCBI Official Full Name

Homo sapiens ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), mRNA

NCBI Official Synonym Full Names

ubiquitin specific peptidase 14

NCBI Official Symbol

USP14

NCBI Official Synonym Symbols

TGT

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 14

UniProt Synonym Protein Names

Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

UniProt Gene Name

USP14

UniProt Synonym Gene Names

TGT

UniProt Entry Name

UBP14_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 14

NCBI Summary for USP14

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for USP14

USP14: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Belongs to the peptidase C19 family. USP14/UBP6 subfamily.

Protein type: Ubiquitin-specific protease; Ubiquitin conjugating system; EC 3.4.19.12; Protease

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: cell surface; cytoplasm; cytoplasmic membrane-bound vesicle

Molecular Function: cysteine-type endopeptidase activity; endopeptidase inhibitor activity; protein binding; tRNA guanylyltransferase activity; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; regulation of chemotaxis

Research Articles on USP14

1. our findings suggested that USP14 is involved in the progression of hepatocellular carcinoma(HCC) and may be a useful therapeutic target in HCC

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with USP14 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with USP14 and Neoplasms
Disease Models, Animal Antibodies	>4 publications with USP14 and Disease Models, Animal
Brain Diseases Antibodies	>2 publications with USP14 and Brain Diseases
Inflammation Antibodies	>2 publications with USP14 and Inflammation
Liver Neoplasms Antibodies	>2 publications with USP14 and Liver Neoplasms
Atrophy Antibodies	>2 publications with USP14 and Atrophy
Liver Diseases Antibodies	>2 publications with USP14 and Liver Diseases
Infertility, Male Antibodies	>1 publications with USP14 and Infertility, Male
Genital Diseases, Male Antibodies	>1 publications with USP14 and Genital Diseases, Male
Immune System Diseases Antibodies	>1 publications with USP14 and Immune System Diseases

Organs/Tissues associated with USP14 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with USP14 and Brain
Lung Antibodies	>2 publications with USP14 and Lung
Testis Antibodies	>1 publications with USP14 and Testis