USP6 cDNA Clone – Ubiquitin Specific Peptidase 6 (Tre-2 Oncogene) (Human)

USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.19.12; Protease; Oncoprotein; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cytoplasm; lysosome; plasma membrane; recycling endosome

Molecular Function: calmodulin binding; cysteine-type endopeptidase activity; nucleic acid binding; protein binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination