Human VAV1 cDNA Clone Expression Plasmid – Cat# MBS1273575

VAV1 cDNA Clone – Vav 1 Guanine Nucleotide Exchange Factor (Human)

Name: VAV1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273575
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273575

MBS1273575 is a cDNA clone targeting VAV1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VAV1, cDNA Clone

Full Product Name

VAV1 cDNA Clone

Product Gene Name

VAV1 cdna clone

Sequence

atgattgtgc taccactgta ctccagactg gacaaaagat tcctgtgcct taagaacatt agaaccttcc tgtccacctg ctgtgagaag ttcggcctca agcggagcga gctcttcgaa gcctttgacc tcttcgatgt gcaggatttt ggcaaggtca tctacaccct gtctgctctg tcctggaccc cgatcgccca gaacaggggg atcatgccct tccccaccga ggaggagagt gtaggtgatg aagacatcta cagtggcctg tccgaccaga tcgacgacac ggtggaggag gatgaggacc tgtatgactg cgtggagaat gaggaggcgg aaggcgacga gatctatgag gacctcatgc gctcggagcc cgtgtccatg ccgcccaaga tgacagagta tgacaagcgc tgctgctgcc tgcgggagat ccagcagacg gaggagaagt acactgacac gctgggctcc atccagcagc atttcttgaa gcccctgcaa cggttcctga aacctcaaga cattgagatc atctttatca acattgagga cctgcttcgt gttcatactc acttcctaaa ggagatgaag gaagccctgg gcacccctgg cgcagccaat ctctaccagg tcttcatcaa atacaaggag aggttcctcg tctatggccg ctactgcagc caggtggagt cagccagcaa acacctggac cgtgtggccg cagcccggga ggacgtgcag atgaagctgg aggaatgttc tcagagagcc aacaacggga ggttcaccct gcgggacctg ctgatggtgc ctatgcagcg agttctcaaa tatcacctcc ttctccagga gctggtgaaa cacacgcagg aggcgatgga gaaggagaac ctgcggctgg ccctggatgc catgagggac ctggctcagt gcgtgaacga ggtcaagcga gacaacgaga cactgcgaca gatcaccaat ttccagctgt ccattgagaa cctggaccag tctctggctc actatggccg gcccaagatc gacggggaac tcaagatcac ctcggtggaa cggcgctcca agatggacag gtatgccttc ctgctcgaca aagctctact catctgtaag cgcaggggag actcctatga cctcaaggac tttgtaaacc tgcacagctt ccaggttcgg gatgactctt caggagaccg agacaacaag aagtggagcc acatgttcct cctgatcgag gaccaaggtg cccagggcta tgagctgttc ttcaagacaa gagaattgaa gaagaagtgg atggagcagt ttgagatggc catctccaac atctatccgg agaatgccac cgccaacggg catgacttcc agatgttctc ctttgaggag accacatcct gcaaggcctg tcagatgctg cttagaggta ccttctatca gggctaccgc tgccatcggt gccgggcatc tgcacacaag gagtgtctgg ggagggtccc tccatgtggc cgacatgggc aagatttccc aggaactatg aagaaggaca aactacatcg cagggctcag gacaaaaaga ggaatgagct gggtctgccc aagatggagg tgtttcagga atactacggg cttcctccac cccctggagc cattggaccc tttctacggc tcaaccctgg agacattgtg gagctcacga aggctgaggc tgaacagaac tggtgggagg gcagaaatac atctactaat gaaattggct ggtttccttg taacagggtg aagccctatg tccatggccc tcctcaggac ctgtctgttc atctctggta cgcaggcccc atggagcggg caggggcaga gagcatcctg gccaaccgct cggacgggac tttcttggtg cggcagaggg tgaaggatgc agcagaattt gccatcagca ttaaatataa cgtcgaggtc aagcacatta aaatcatgac agcagaagga ctgtaccgga tcacagagaa aaaggctttc cgggggctta cggagctggt ggagttttac cagcagaact ctctaaagga ttgcttcaag tctctggaca ccaccttgca gttccccttc aaggagcctg aaaagagaac catcagcagg ccagcagtgg gaagcacaaa gtattttggc acagccaaag cccgctatga cttctgcgcc cgagaccgat cagagctgtc gctcaaggag ggtgacatca tcaagatcct taacaagaag ggacagcaag gctggtggcg aggggagatc tatggccggg ttggctggtt ccctgccaac tacgtggagg aagattattc tgaatactgc tga

Molecular Weight

94,493 Da

OMIM

164875

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of VAV1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VAV1. It may not necessarily be applicable to this product.

NCBI GI #

33991319

NCBI GeneID

7409

NCBI Accession #

BC013361

UniProt Secondary Accession #

Q15860; B4DVK9; M0QXX6

UniProt Related Accession #

P15498

NCBI Official Full Name

Homo sapiens vav 1 guanine nucleotide exchange factor, mRNA

NCBI Official Synonym Full Names

vav guanine nucleotide exchange factor 1

NCBI Official Symbol

VAV1

NCBI Official Synonym Symbols

VAV

UniProt Protein Name

Proto-oncogene vav

Protein Family

Proto-oncogene

UniProt Gene Name

VAV1

UniProt Synonym Gene Names

VAV

UniProt Entry Name

VAV_HUMAN

NCBI Protein Information

proto-oncogene vav

NCBI Summary for VAV1

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

UniProt Comments for VAV1

VAV1: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; transcription factor activity

Biological Process: phosphoinositide-mediated signaling; platelet activation; positive regulation of apoptosis; regulation of cell size; regulation of GTPase activity; regulation of phosphoinositide 3-kinase cascade; regulation of small GTPase mediated signal transduction; T cell costimulation; vascular endothelial growth factor receptor signaling pathway

Research Articles on VAV1

1. revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta, epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with VAV1 cdna clone

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent Vav1 Pathway antibodies	CD28 Dependent Vav1 Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram

Diseases associated with VAV1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>95 publications with VAV1 and Neoplasms
Immune System Diseases Antibodies	>61 publications with VAV1 and Immune System Diseases
Leukemia Antibodies	>47 publications with VAV1 and Leukemia
Inflammation Antibodies	>19 publications with VAV1 and Inflammation
Carcinoma Antibodies	>16 publications with VAV1 and Carcinoma
Cardiovascular Diseases Antibodies	>12 publications with VAV1 and Cardiovascular Diseases
Necrosis Antibodies	>11 publications with VAV1 and Necrosis
Adenocarcinoma Antibodies	>10 publications with VAV1 and Adenocarcinoma
Lung Neoplasms Antibodies	>6 publications with VAV1 and Lung Neoplasms
Congenital Abnormalities Antibodies	>4 publications with VAV1 and Congenital Abnormalities

Organs/Tissues associated with VAV1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>369 publications with VAV1 and Blood
Bone Antibodies	>37 publications with VAV1 and Bone
Bone Marrow Antibodies	>33 publications with VAV1 and Bone Marrow
Thymus Antibodies	>23 publications with VAV1 and Thymus
Spleen Antibodies	>16 publications with VAV1 and Spleen
Lung Antibodies	>14 publications with VAV1 and Lung
Lymph Node Antibodies	>11 publications with VAV1 and Lymph Node
Lymph Antibodies	>8 publications with VAV1 and Lymph
Brain Antibodies	>5 publications with VAV1 and Brain
Ovary Antibodies	>3 publications with VAV1 and Ovary