Human VPS35 cDNA Clone Expression Plasmid – Cat# MBS1276775

VPS35 cDNA Clone – Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (Human)

Name: VPS35 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1276775
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276775

MBS1276775 is a cDNA clone targeting VPS35. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VPS35, cDNA Clone

Full Product Name

VPS35 cDNA Clone

Product Gene Name

VPS35 cdna clone

Sequence

atgcctacaa cacagcagtc ccctcaggat gagcaggaaa agctcttgga tgaagccata caggctgtga aggtccagtc attccaaatg aagagatgcc tggacaaaaa caagcttatg gatgctctaa aacatgcttc taatatgctt ggtgaactcc ggacttctat gttatcacca aagagttact atgaacttta tatggccatt tctgatgaac tgcactactt ggaggtctac ctgacagatg agtttgctaa aggaaggaaa gtggcagatc tctacgaact tgtacagtat gctggaaaca ttatcccaag gctttacctt ttgatcacag ttggagttgt atatgtcaag tcatttcctc agtccaggaa ggatattttg aaagatttgg tagaaatgtg ccgtggtgtg caacatccct tgaggggtct gtttcttcga aattaccttc ttcagtgtac cagaaatatc ttacctgatg aaggagagcc aacagatgaa gaaacaactg gtgacatcag tgattccatg gattttgtac tgctcaactt tgcagaaatg aacaagctct gggtgcgaat gcagcatcag ggacatagcc gagatagaga aaaaagagaa cgagaaagac aagaactgag aattttagtg ggaacaaatt tggtgcgcct cagtcagttg gaaggtgtaa atgtggaacg ttacaaacag attgttttga ctggcatatt ggagcaagtt gtaaactgta gggatgcttt ggctcaagaa tatctcatgg agtgtattat tcaggttttc cctgatgaat ttcacctcca gactttgaat ccttttcttc gggcctgtgc tgagttacac cagaatgtaa atgtgaagaa cataatcatt gctttaattg atagattagc tttatttgct caccgtgaag atggacctgg aatcccagcg gatattaaac tttttgatat attttcacag caggtggcta cagtgataca gtctagacaa gacatgcctt cagaggatgt tgtatcttta caagtctctc tgattaatct tgccatgaaa tgttaccctg atcgtgtgga ctatgttgat aaagttctag aaacaacagt ggagatattc aataagctca accttgaaca tattgctacc agtagtgcag tttcaaagga actcaccaga cttttgaaaa taccagttga cacttacaac aatattttaa cagtcttgaa attaaaacat tttcacccac tctttgagta ctttgactac gagtccagaa agagcatgag ttgttatgtg cttagtaatg ttctggatta taacacagaa attgtctctc aagaccaggt ggattccata atgaatttgg tatccacgtt gattcaagat cagccagatc aacctgtaga agaccctgat ccagaagatt ttgctgatga gcagagcctt gtgggccgct tcattcatct gctgcgctct gaggaccctg accagcagta cttgattttg aacacagcac gaaaacattt tggagctggt ggaaatcagc ggattcgctt cacactgcca cctttggtat ttgcagctta ccagctggct tttcgatata aagagaattc taaagtggat gacaaatggg aaaagaaatg ccagaagatt ttttcatttg cccaccagac tatcagtgct ttgatcaaag cagagctggc agaattgccc ttaagacttt ttcttcaagg agcactagct gctggggaaa ttggttttga aaatcatgag acagtcgcat atgaattcat gtcccaggca ttttctctgt atgaagatga aatcagcgat tccaaagcac agctagctgc catcaccttg atcattggca cttttgaaag gatgaagtgc ttcagtgaag agaatcatga acctctgagg actcagtgtg cccttgctgc atccaaactt ctaaagaaac ctgatcaggg ccgagctgtg agcacctgtg cacatctctt ctggtctggc agaaacacgg acaaaaatgg ggaggagctt cacggaggca agagggtaat ggagtgccta aaaaaagctc taaaaatagc aaatcagtgc atggacccct ctctacaagt gcagcttttt atagaaattc tgaacagata tatctatttt tatgaaaagg aaaatgatgc ggtaacaatt caggttttaa accagcttat ccaaaagatt cgagaagacc tcccgaatct tgaatccagt gaagaaacag agcagattaa caaacatttt cataacacac tggagcattt gcgcttgcgg cgggaatcac cagaatccga ggggccaatt tatgaaggtc tcatccttta a

Molecular Weight

91,707 Da

OMIM

601501

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of VPS35 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS35. It may not necessarily be applicable to this product.

NCBI GI #

37589031

NCBI GeneID

55737

NCBI Accession #

BC002414

UniProt Secondary Accession #

Q561W2; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2

NCBI Official Full Name

Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae), mRNA

UniProt Protein Name

Vacuolar protein sorting-associated protein 35

UniProt Synonym Protein Names

Maternal-embryonic 3; Vesicle protein sorting 35

Protein Family

Vacuolar protein sorting-associated protein

UniProt Gene Name

VPS35

UniProt Synonym Gene Names

MEM3; hVPS35

UniProt Entry Name

VPS35_HUMAN

UniProt Comments for VPS35

VPS35: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: cytosol; early endosome; endosome; late endosome; lysosomal membrane; retromer complex

Molecular Function: protein binding; protein transporter activity

Biological Process: intracellular protein transport; regulation of macroautophagy; regulation of protein stability; retrograde transport, endosome to Golgi; transcytosis; Wnt receptor signaling pathway

Disease: Parkinson Disease 17

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with VPS35 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>31 publications with VPS35 and Nervous System Diseases
Neoplasms Antibodies	>4 publications with VPS35 and Neoplasms
Kidney Diseases Antibodies	>3 publications with VPS35 and Kidney Diseases
Lung Neoplasms Antibodies	>1 publications with VPS35 and Lung Neoplasms
Cognition Disorders Antibodies	>1 publications with VPS35 and Cognition Disorders
Nervous System Malformations Antibodies	>1 publications with VPS35 and Nervous System Malformations
Necrosis Antibodies	>1 publications with VPS35 and Necrosis

Organs/Tissues associated with VPS35 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>14 publications with VPS35 and Brain
Kidney Antibodies	>4 publications with VPS35 and Kidney
Heart Antibodies	>3 publications with VPS35 and Heart
Blood Antibodies	>3 publications with VPS35 and Blood
Intestine Antibodies	>2 publications with VPS35 and Intestine
Nerve Antibodies	>2 publications with VPS35 and Nerve
Testis Antibodies	>2 publications with VPS35 and Testis
Embryonic Tissue Antibodies	>2 publications with VPS35 and Embryonic Tissue
Liver Antibodies	>1 publications with VPS35 and Liver
Placenta Antibodies	>1 publications with VPS35 and Placenta